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Peptide record

TPDB09798

Antibacterial Toxicity standard

21 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB09798

Activity

Antibacterial Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 21-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.

Sequence

GSKKPVPIIYCNRRSGKCQRM

FASTA

>TPDB09798|Antibacterial;Toxicity|length=21
GSKKPVPIIYCNRRSGKCQRM

Formula C102H177N35O27S3

Absent Amino Acids ADEHLFTW

Common Amino Acids RK

Mass 2421.93

PI 10.88

Basic Residues 6

Acidic Residues 0

Hydrophobic Residues 5

Net Charge +6

Boman Index 5.38

Hydrophobicity -0.905

Aliphatic Index 50.95

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 1615

Absorbance 280nm 66.68

Polar Residues 7

number

Amino Acid Distribution

A: 0 R: 3 N: 1 D: 0 C: 2 E: 0 Q: 1 G: 2 H: 0 I: 2 L: 0 K: 3 M: 1 F: 0 P: 2 S: 2 T: 0 W: 0 Y: 1 V: 1

Length

Formula

C102H177N35O27S3

Mass

2421.93

10.88

Net Charge

Boman Index

5.38

Hydrophobicity

-0.905

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4-12.5 µg/mL

Target

Target Organism Escherichia coli E79466 or ATCC 25922 and 7 more resistant strains

Source & Reference

Database Source NA

Other

Evidence Text

active against E. coli E79466 or ATCC 25922 and 7 more resistant strains (MIC 4-12.5 ug/ml), K. pneumoniae ATCC 700603 or 7 resistant clinical strains (MIC 4-8 ug/ml), A.baumannii A

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4-8 µg/mL

Target

Target Organism Klebsiella pneumoniae ATCC 700603 or 7 resistant clinical strains

Source & Reference

Database Source NA

Other

Evidence Text

ive against E. coli E79466 or ATCC 25922 and 7 more resistant strains (MIC 4-12.5 ug/ml), K. pneumoniae ATCC 700603 or 7 resistant clinical strains (MIC 4-8 ug/ml), A.baumannii ATCC 19606 or 8 clincial strains (MIC>128 ug/ml), S.maltophilia ATCC 13637 o

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >128 µg/mL

Target

Target Organism A.baumannii ATCC 19606 or 8 clincial strains

Source & Reference

Database Source NA

Other

Evidence Text

4-12.5 ug/ml), K. pneumoniae ATCC 700603 or 7 resistant clinical strains (MIC 4-8 ug/ml), A.baumannii ATCC 19606 or 8 clincial strains (MIC>128 ug/ml), S.maltophilia ATCC 13637 or 5 resistant strains (MIC >128 ug/ml), P.aeruginosa ATCC 1544

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >128 µg/mL

Target

Target Organism S.maltophilia ATCC 13637 or 5 resistant strains

Source & Reference

Database Source NA

Other

Evidence Text

al strains (MIC 4-8 ug/ml), A.baumannii ATCC 19606 or 8 clincial strains (MIC>128 ug/ml), S.maltophilia ATCC 13637 or 5 resistant strains (MIC >128 ug/ml), P.aeruginosa ATCC 15442 or 7 resistant clincial strains (MIC>128 ug/ml), E. cloacae ATCC

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >128 µg/mL

Target

Target Organism P.aeruginosa ATCC 15442 or 7 resistant clincial strains

Source & Reference

Database Source NA

Other

Evidence Text

trains (MIC>128 ug/ml), S.maltophilia ATCC 13637 or 5 resistant strains (MIC >128 ug/ml), P.aeruginosa ATCC 15442 or 7 resistant clincial strains (MIC>128 ug/ml), E. cloacae ATCC 13047 or 6 clinical strains (MIC 8-16 ug/ml), S.marcescens ATCC 14041 or

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8-16 µg/mL

Target

Target Organism Enterobacter cloacae ATCC 13047 or 6 clinical strains

Source & Reference

Database Source NA

Other

Evidence Text

MIC >128 ug/ml), P.aeruginosa ATCC 15442 or 7 resistant clincial strains (MIC>128 ug/ml), E. cloacae ATCC 13047 or 6 clinical strains (MIC 8-16 ug/ml), S.marcescens ATCC 14041 or 5 clincial strains (MIC > 128 ug/ml), E. aerogenes ATCC 49701

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µg/mL

Target

Target Organism Enterobacter aerogenes ATCC 49701 or 7 clinical strains

Source & Reference

Database Source NA

Other

Evidence Text

trains (MIC 8-16 ug/ml), S.marcescens ATCC 14041 or 5 clincial strains (MIC > 128 ug/ml), E. aerogenes ATCC 49701 or 7 clinical strains (MIC 4 ug/ml), P.mirabilis ATCC 12453 or 6 clinical strains (MIC >128 ug/ml), K. ornithinolytica ATCC 3

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >128 µg/mL

Target

Target Organism P.mirabilis ATCC 12453 or 6 clinical strains

Source & Reference

Database Source NA

Other

Evidence Text

l strains (MIC > 128 ug/ml), E. aerogenes ATCC 49701 or 7 clinical strains (MIC 4 ug/ml), P.mirabilis ATCC 12453 or 6 clinical strains (MIC >128 ug/ml), K. ornithinolytica ATCC 31898 or 4 clinical strains (MIC 8 ug/ml), K. oxytoca ATCC 43086

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8 µg/mL

Target

Target Organism K. ornithinolytica ATCC 31898 or 4 clinical strains

Source & Reference

Database Source NA

Other

Evidence Text

cal strains (MIC 4 ug/ml), P.mirabilis ATCC 12453 or 6 clinical strains (MIC >128 ug/ml), K. ornithinolytica ATCC 31898 or 4 clinical strains (MIC 8 ug/ml), K. oxytoca ATCC 43086 or 4 clincial strains (MIC 8 ug/ml), S.aureus ATCC 12228 or 7 clin

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8 µg/mL

Target

Target Organism Klebsiella oxytoca ATCC 43086 or 4 clincial strains

Source & Reference

Database Source NA

Other

Evidence Text

ains (MIC >128 ug/ml), K. ornithinolytica ATCC 31898 or 4 clinical strains (MIC 8 ug/ml), K. oxytoca ATCC 43086 or 4 clincial strains (MIC 8 ug/ml), S.aureus ATCC 12228 or 7 clinical strains (MIC > 128 ug/ml), S.hominis ATCC 29970 or 9 c

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >128 µg/mL

Target

Target Organism S.hominis ATCC 29970 or 9 clinical strains

Source & Reference

Database Source NA

Other

Evidence Text

ncial strains (MIC 8 ug/ml), S.aureus ATCC 12228 or 7 clinical strains (MIC > 128 ug/ml), S.hominis ATCC 29970 or 9 clinical strains (MIC >128 ug/ml), E. faecium ATCC 29212 or 5 clinical strains (MIC 64-128 ug/ml) 1 strain 128 ug/ml, S.aga

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 64-128 µg/mL

Target

Target Organism E. faecium ATCC 29212 or 5 clinical strains

Source & Reference

Database Source NA

Other

Evidence Text

l strains (MIC > 128 ug/ml), S.hominis ATCC 29970 or 9 clinical strains (MIC >128 ug/ml), E. faecium ATCC 29212 or 5 clinical strains (MIC 64-128 ug/ml) 1 strain 128 ug/ml, S.agalactiae (MIC>128 ug/ml), and B.subtilis (MIC 104 uM) ( Wu et al.

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >128 µg/mL

Target

Target Organism S.agalactiae

Source & Reference

Database Source NA

Other

Evidence Text

g/ml), E. faecium ATCC 29212 or 5 clinical strains (MIC 64-128 ug/ml) 1 strain 128 ug/ml, S.agalactiae (MIC>128 ug/ml), and B.subtilis (MIC 104 uM) ( Wu et al., 2011 ). It also binds LPS and can agglutinates

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 104 µM

Target

Target Organism B.subtilis

Source & Reference

Database Source NA

Other

Evidence Text

clinical strains (MIC 64-128 ug/ml) 1 strain 128 ug/ml, S.agalactiae (MIC>128 ug/ml), and B.subtilis (MIC 104 uM) ( Wu et al., 2011 ). It also binds LPS and can agglutinates bacteria (bacteria-agglutinat

Evidence 15 Activity

Activity

Activity Endpoint 5% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 100 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

5% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

The activity of antimicrobial peptide S-thanatin is independent on multidrug-resistant spectrum of bacteria. | Peptides | 2011