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Peptide record

TPDB09795

Antibacterial Antifungal Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB09795
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP ToxinPred 3.0
standard
No
A 21-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
GLLSGILGAGKKIVCGLSGLC
Physicochemical Analysis
C86H155N23O24S2
RNDEQHMFPTWY
G
1959.44
9.11
2
0
9
+2
-1.70
1.295
148.57
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
125
6.38
4
Residue Composition
number
1
A
0
R
0
N
0
D
2
C
0
E
0
Q
6
G
0
H
2
I
5
L
2
K
0
M
0
F
0
P
2
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 6 H: 0 I: 2 L: 5 K: 2 M: 0 F: 0 P: 0 S: 2 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
21
C86H155N23O24S2
1959.44
9.11
+2
-1.70
1.295
Evidence Records 22 records
Evidence 1 Activity

Activity

MIC
Antibacterial
10 µg/mL

Target

Staphylococcus aureus ATCC25923

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against S. aureus ATCC25923 (MIC 10 ug/ml), S. aureus IS10# (MIC 5 ug/ml), S. aureus IS37# (MIC 10 ug/ml), E. faecalis ATCC29212 (MI
Evidence 2 Activity

Activity

MIC
Antibacterial
10 µg/mL

Target

Enterococcus faecalis ATCC29212

Source & Reference

dbAMP

Other

ATCC25923 (MIC 10 ug/ml), S. aureus IS10# (MIC 5 ug/ml), S. aureus IS37# (MIC 10 ug/ml), E. faecalis ATCC29212 (MIC 10 ug/ml), E. coli ATCC25922 (MIC 5 ug/ml), E. coli IS37# (MIC 10 ug/ml), E. coli IS117# (MIC 10 ug
Evidence 3 Activity

Activity

MIC
Antibacterial
5 µg/mL

Target

Escherichia coli ATCC25922

Source & Reference

dbAMP

Other

S10# (MIC 5 ug/ml), S. aureus IS37# (MIC 10 ug/ml), E. faecalis ATCC29212 (MIC 10 ug/ml), E. coli ATCC25922 (MIC 5 ug/ml), E. coli IS37# (MIC 10 ug/ml), E. coli IS117# (MIC 10 ug/ml), E. coli IS218# (MIC 20 ug/m
Evidence 4 Activity

Activity

MIC
Antibacterial
1 µg/mL

Target

Klebsiella pneumoniae ATCC700603

Source & Reference

dbAMP

Other

IS117# (MIC 10 ug/ml), E. coli IS218# (MIC 20 ug/ml), E. cloacae ATCC13047 (MIC 5 and 5), K. pneumoniae ATCC700603 (MIC 1 ug/ml), K. pneumoniae IS 59# (MIC 20 ug/ml), B. dysenteriae (MIC 10 ug/ml), B. pyocyaneus CMCCB1
Evidence 5 Activity

Activity

MIC
Antibacterial
10 µg/mL

Target

B. dysenteriae

Source & Reference

dbAMP

Other

IC 5 and 5), K. pneumoniae ATCC700603 (MIC 1 ug/ml), K. pneumoniae IS 59# (MIC 20 ug/ml), B. dysenteriae (MIC 10 ug/ml), B. pyocyaneus CMCCB1010 (MIC 1 ug/ml), P. aeruginosa ATCC27853 (MIC 10 ug/ml), P. aerugi
Evidence 6 Activity

Activity

MIC
Antibacterial
1 µg/mL

Target

B. pyocyaneus CMCCB1010

Source & Reference

dbAMP

Other

700603 (MIC 1 ug/ml), K. pneumoniae IS 59# (MIC 20 ug/ml), B. dysenteriae (MIC 10 ug/ml), B. pyocyaneus CMCCB1010 (MIC 1 ug/ml), P. aeruginosa ATCC27853 (MIC 10 ug/ml), P. aeruginosa IS350# (MIC 20 ug/ml), C. albicans
Evidence 7 Activity

Activity

MIC
Antibacterial
10 µg/mL

Target

Pseudomonas aeruginosa ATCC27853

Source & Reference

dbAMP

Other

59# (MIC 20 ug/ml), B. dysenteriae (MIC 10 ug/ml), B. pyocyaneus CMCCB1010 (MIC 1 ug/ml), P. aeruginosa ATCC27853 (MIC 10 ug/ml), P. aeruginosa IS350# (MIC 20 ug/ml), C. albicans ATCC2002 (MIC 2 ug/ml), C. albicans ATC
Evidence 8 Activity

Activity

MIC
Antibacterial
2 µg/mL

Target

Candida albicans ATCC2002

Source & Reference

dbAMP

Other

IC 1 ug/ml), P. aeruginosa ATCC27853 (MIC 10 ug/ml), P. aeruginosa IS350# (MIC 20 ug/ml), C. albicans ATCC2002 (MIC 2 ug/ml), C. albicans ATCC90028 (MIC 2.5 ug/ml), C. parapsilosis ATCC22019 (MIC 5 ug/ml). This ran
Evidence 9 Activity

Activity

MIC
Antibacterial
2.5 µg/mL

Target

Candida albicans ATCC90028

Source & Reference

dbAMP

Other

(MIC 10 ug/ml), P. aeruginosa IS350# (MIC 20 ug/ml), C. albicans ATCC2002 (MIC 2 ug/ml), C. albicans ATCC90028 (MIC 2.5 ug/ml), C. parapsilosis ATCC22019 (MIC 5 ug/ml). This rana box is insignificant for antimicrobia
Evidence 10 Activity

Activity

MIC
Antibacterial
5 µg/mL

Target

C. parapsilosis ATCC22019

Source & Reference

dbAMP

Other

MIC 20 ug/ml), C. albicans ATCC2002 (MIC 2 ug/ml), C. albicans ATCC90028 (MIC 2.5 ug/ml), C. parapsilosis ATCC22019 (MIC 5 ug/ml). This rana box is insignificant for antimicrobial activity since Nigrocin-HLD retained si
Evidence 11 Activity

Activity

MIC
Antifungal
10 µg/mL

Target

Staphylococcus aureus ATCC25923

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against S. aureus ATCC25923 (MIC 10 ug/ml), S. aureus IS10# (MIC 5 ug/ml), S. aureus IS37# (MIC 10 ug/ml), E. faecalis ATCC29212 (MI
Evidence 12 Activity

Activity

MIC
Antifungal
10 µg/mL

Target

Enterococcus faecalis ATCC29212

Source & Reference

dbAMP CAFPdb Antifungipept

Other

ATCC25923 (MIC 10 ug/ml), S. aureus IS10# (MIC 5 ug/ml), S. aureus IS37# (MIC 10 ug/ml), E. faecalis ATCC29212 (MIC 10 ug/ml), E. coli ATCC25922 (MIC 5 ug/ml), E. coli IS37# (MIC 10 ug/ml), E. coli IS117# (MIC 10 ug
Evidence 13 Activity

Activity

MIC
Antifungal
5 µg/mL

Target

Escherichia coli ATCC25922

Source & Reference

dbAMP CAFPdb Antifungipept

Other

S10# (MIC 5 ug/ml), S. aureus IS37# (MIC 10 ug/ml), E. faecalis ATCC29212 (MIC 10 ug/ml), E. coli ATCC25922 (MIC 5 ug/ml), E. coli IS37# (MIC 10 ug/ml), E. coli IS117# (MIC 10 ug/ml), E. coli IS218# (MIC 20 ug/m
Evidence 14 Activity

Activity

MIC
Antifungal
1 µg/mL

Target

Klebsiella pneumoniae ATCC700603

Source & Reference

dbAMP CAFPdb Antifungipept

Other

IS117# (MIC 10 ug/ml), E. coli IS218# (MIC 20 ug/ml), E. cloacae ATCC13047 (MIC 5 and 5), K. pneumoniae ATCC700603 (MIC 1 ug/ml), K. pneumoniae IS 59# (MIC 20 ug/ml), B. dysenteriae (MIC 10 ug/ml), B. pyocyaneus CMCCB1
Evidence 15 Activity

Activity

MIC
Antifungal
10 µg/mL

Target

B. dysenteriae

Source & Reference

dbAMP CAFPdb Antifungipept

Other

IC 5 and 5), K. pneumoniae ATCC700603 (MIC 1 ug/ml), K. pneumoniae IS 59# (MIC 20 ug/ml), B. dysenteriae (MIC 10 ug/ml), B. pyocyaneus CMCCB1010 (MIC 1 ug/ml), P. aeruginosa ATCC27853 (MIC 10 ug/ml), P. aerugi
Evidence 16 Activity

Activity

MIC
Antifungal
1 µg/mL

Target

B. pyocyaneus CMCCB1010

Source & Reference

dbAMP CAFPdb Antifungipept

Other

700603 (MIC 1 ug/ml), K. pneumoniae IS 59# (MIC 20 ug/ml), B. dysenteriae (MIC 10 ug/ml), B. pyocyaneus CMCCB1010 (MIC 1 ug/ml), P. aeruginosa ATCC27853 (MIC 10 ug/ml), P. aeruginosa IS350# (MIC 20 ug/ml), C. albicans
Evidence 17 Activity

Activity

MIC
Antifungal
10 µg/mL

Target

Pseudomonas aeruginosa ATCC27853

Source & Reference

dbAMP CAFPdb Antifungipept

Other

59# (MIC 20 ug/ml), B. dysenteriae (MIC 10 ug/ml), B. pyocyaneus CMCCB1010 (MIC 1 ug/ml), P. aeruginosa ATCC27853 (MIC 10 ug/ml), P. aeruginosa IS350# (MIC 20 ug/ml), C. albicans ATCC2002 (MIC 2 ug/ml), C. albicans ATC
Evidence 18 Activity

Activity

MIC
Antifungal
2 µg/mL

Target

Candida albicans ATCC2002

Source & Reference

dbAMP CAFPdb Antifungipept

Other

IC 1 ug/ml), P. aeruginosa ATCC27853 (MIC 10 ug/ml), P. aeruginosa IS350# (MIC 20 ug/ml), C. albicans ATCC2002 (MIC 2 ug/ml), C. albicans ATCC90028 (MIC 2.5 ug/ml), C. parapsilosis ATCC22019 (MIC 5 ug/ml). This ran
Evidence 19 Activity

Activity

MIC
Antifungal
2.5 µg/mL

Target

Candida albicans ATCC90028

Source & Reference

dbAMP CAFPdb Antifungipept

Other

(MIC 10 ug/ml), P. aeruginosa IS350# (MIC 20 ug/ml), C. albicans ATCC2002 (MIC 2 ug/ml), C. albicans ATCC90028 (MIC 2.5 ug/ml), C. parapsilosis ATCC22019 (MIC 5 ug/ml). This rana box is insignificant for antimicrobia
Evidence 20 Activity

Activity

MIC
Antifungal
5 µg/mL

Target

C. parapsilosis ATCC22019

Source & Reference

dbAMP CAFPdb Antifungipept

Other

MIC 20 ug/ml), C. albicans ATCC2002 (MIC 2 ug/ml), C. albicans ATCC90028 (MIC 2.5 ug/ml), C. parapsilosis ATCC22019 (MIC 5 ug/ml). This rana box is insignificant for antimicrobial activity since Nigrocin-HLD retained si
Evidence 21 Activity

Activity

70% Hemolysis
Toxicity
128 µM
Hemolytic Cytotoxic
70% Hemolysis | 128 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Modification Targeting the "Rana Box" Motif of a Novel Nigrocin Peptide From Hylarana latouchii Enhances and Broadens Its Potency Against Multiple Bacteria. | Front Microbiol | 2018
Evidence 22 Activity

Activity

30% Killing
Toxicity
128 µM
Cytotoxic
30% Killing | 128 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Modification Targeting the "Rana Box" Motif of a Novel Nigrocin Peptide From Hylarana latouchii Enhances and Broadens Its Potency Against Multiple Bacteria. | Front Microbiol | 2018