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Peptide record

TPDB09794

Antibacterial Antifungal Hemolysis Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB09794
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia CAFPdb dbAMP HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 21-aa standard-residue multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.
Sequence
GLLGKILGVEKKVLCGLSGMC
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C93H168N24O25S3
ARNDQHFPTWY
GL
2118.68
9.08
3
1
9
+2
-0.97
0.990
139.05
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
125
0.06
3
Residue Composition
number
0
A
0
R
0
N
0
D
2
C
1
E
0
Q
5
G
0
H
1
I
5
L
3
K
1
M
0
F
0
P
1
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 2 E: 1 Q: 0 G: 5 H: 0 I: 1 L: 5 K: 3 M: 1 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
21 reviewed residue count
C93H168N24O25S3 sequence-only estimate (linear, free termini)
2118.68 sequence-only estimate (linear, free termini)
9.08 sequence-only estimate (linear, free termini)
+2 sequence-only estimate (linear, free termini)
-0.97 sequence-only estimate (linear, free termini)
0.990 sequence-only estimate (linear, free termini)
Evidence Records 3 records
Evidence 1 Activity

Activity

60% Hemolysis
Toxicity
50 µg/mL
Hemolytic Cytotoxic
60% Hemolysis | 50 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Anti-infection peptidomics of amphibian skin | Mol Cell Proteomics | 2007
Evidence 2 Activity

Activity

(36.7±5.2)% degranulation
Toxicity
50 µg/mL
Cytotoxic
(36.7±5.2)% degranulation | 50 | µg/mL | target cell: Human mast cells

Target

Human mast cells

Source & Reference

NA
DBAASP
Anti-infection peptidomics of amphibian skin | Mol Cell Proteomics | 2007
Evidence 3 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis