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Peptide record

TPDB09792

Antibacterial Anticancer Antifungal Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB09792
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP
standard
No
A 21-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
GIFSKLAGKKIKNLLISGLKG
Physicochemical Analysis
C102H181N27O25
RDCEQHMPTWYV
K
2185.72
11.12
5
0
9
+5
1.20
0.338
134.76
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
3
Residue Composition
number
1
A
0
R
1
N
0
D
0
C
0
E
0
Q
4
G
0
H
3
I
4
L
5
K
0
M
1
F
0
P
2
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 4 H: 0 I: 3 L: 4 K: 5 M: 0 F: 1 P: 0 S: 2 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
21
C102H181N27O25
2185.72
11.12
+5
1.20
0.338
Evidence Records 7 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.125 µM

Target

Corynebacterium jeikeium ATCC BAA-949

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
ent studies: active against S. agalactiae and P. aeruginosa/biofilms. Also active against C. jeikeium ATCC BAA-949 (MIC 0.125 uM) ( Bruno Casciaro et al., 2020 ). Chemotactic to Human HaCaT Keratinocytes in an EGF Recep
Evidence 2 Activity

Activity

MIC
Antifungal
0.125 µM

Target

Corynebacterium jeikeium ATCC BAA-949

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
ent studies: active against S. agalactiae and P. aeruginosa/biofilms. Also active against C. jeikeium ATCC BAA-949 (MIC 0.125 uM) ( Bruno Casciaro et al., 2020 ). Chemotactic to Human HaCaT Keratinocytes in an EGF Recep
Evidence 3 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Human corneal epithelial cells hTCEpi

Target

Human corneal epithelial cells hTCEpi

Source & Reference

NA
DBAASP
Esculentin-1a(1-21)NH2: a frog skin-derived peptide for microbial keratitis. | Cell Mol Life Sci | 2015
Evidence 4 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Esculentin(1-21), an amphibian skin membrane-active peptide with potent activity on both planktonic and biofilm cells of the bacterial pathogen Pseudomonas aeruginosa. | Cell Mol Life Sci | 2013
Evidence 5 Activity

Activity

10% Hemolysis
Toxicity
64 µM
Hemolytic Cytotoxic
10% Hemolysis | 64 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Frog Skin-Derived Peptides Against Corynebacterium jeikeium: Correlation between Antibacterial and Cytotoxic Activities | Antibiotics (Basel) | 2020
Evidence 6 Activity

Activity

20% Killing
Toxicity
64 µM
Cytotoxic
20% Killing | 64 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Frog Skin-Derived Peptides Against Corynebacterium jeikeium: Correlation between Antibacterial and Cytotoxic Activities | Antibiotics (Basel) | 2020
Evidence 7 Activity

Activity

% Hemolysis
Toxicity
10 %
Hemolytic Cytotoxic
Hemolytic_activity: Sheep erythrocytes: 10% Hemolysis=64 µM | Cytotoxicity: HaCat: 20% Killing=64 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Antibiotics (Basel). 2020 Jul 26 9(8):448.