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Peptide record

TPDB09789

Antibacterial Antifungal Hemolysis Toxicity standard

21 amino acids

3D PDB MODEL

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TPDB ID TPDB09789

Activity

Antibacterial Antifungal Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia Antifungipept APD_complete APD_hemolytic PD_Hemolysis ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 21-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.

Sequence

VWLSALKFIGKHLAKHQLSKL

FASTA

>TPDB09789|Antibacterial;Antifungal;Hemolysis;Toxicity|length=21
VWLSALKFIGKHLAKHQLSKL

Formula C116H189N31O25

Absent Amino Acids RNDCEMPTY

Common Amino Acids L

Mass 2417.97

PI 11.00

Basic Residues 6

Acidic Residues 0

Hydrophobic Residues 11

Net Charge +4

Boman Index 0.37

Hydrophobicity 0.271

Aliphatic Index 134.76

Half Life

Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 5500

Absorbance 280nm 227.46

Polar Residues 3

number

Amino Acid Distribution

A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 2 I: 1 L: 5 K: 4 M: 0 F: 1 P: 0 S: 2 T: 0 W: 1 Y: 0 V: 1

Length

Formula

C116H189N31O25

Mass

2417.97

11.00

Net Charge

Boman Index

0.37

Hydrophobicity

0.271

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 3.1-6.3 µM

Target

Target Organism A. baumannii

Source & Reference

Database Source NA

Other

Evidence Text

Bacteriostatic against multidrug-resistant A. baumannii (MIC 3.1-6.3 uM), E. coli (MIC 12.5 uM), K. pneumoniae, S. pyogenes (MIC 50 uM), S. aureus, S. saprophytic

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 12.5 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source NA

Other

Evidence Text

Bacteriostatic against multidrug-resistant A. baumannii (MIC 3.1-6.3 uM), E. coli (MIC 12.5 uM), K. pneumoniae, S. pyogenes (MIC 50 uM), S. aureus, S. saprophyticus, S. epidermidis, V.

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 50 µM

Target

Target Organism Streptococcus pyogenes

Source & Reference

Database Source NA

Other

Evidence Text

multidrug-resistant A. baumannii (MIC 3.1-6.3 uM), E. coli (MIC 12.5 uM), K. pneumoniae, S. pyogenes (MIC 50 uM), S. aureus, S. saprophyticus, S. epidermidis, V. Streptococci (MIC 3.1 uM), and P. aerugi

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 3.1 µM

Target

Target Organism V. Streptococci

Source & Reference

Database Source NA

Other

Evidence Text

uM), K. pneumoniae, S. pyogenes (MIC 50 uM), S. aureus, S. saprophyticus, S. epidermidis, V. Streptococci (MIC 3.1 uM), and P. aeruginosa (MIC 12.5 uM).

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 12.5 µM

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source NA

Other

Evidence Text

IC 50 uM), S. aureus, S. saprophyticus, S. epidermidis, V. Streptococci (MIC 3.1 uM), and P. aeruginosa (MIC 12.5 uM).

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 3.1-6.3 µM

Target

Target Organism A. baumannii

Source & Reference

Database Source Antifungipept

Other

Evidence Text

Bacteriostatic against multidrug-resistant A. baumannii (MIC 3.1-6.3 uM), E. coli (MIC 12.5 uM), K. pneumoniae, S. pyogenes (MIC 50 uM), S. aureus, S. saprophytic

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 12.5 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source Antifungipept

Other

Evidence Text

Bacteriostatic against multidrug-resistant A. baumannii (MIC 3.1-6.3 uM), E. coli (MIC 12.5 uM), K. pneumoniae, S. pyogenes (MIC 50 uM), S. aureus, S. saprophyticus, S. epidermidis, V.

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 50 µM

Target

Target Organism Streptococcus pyogenes

Source & Reference

Database Source Antifungipept

Other

Evidence Text

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 3.1 µM

Target

Target Organism V. Streptococci

Source & Reference

Database Source Antifungipept

Other

Evidence Text

uM), K. pneumoniae, S. pyogenes (MIC 50 uM), S. aureus, S. saprophyticus, S. epidermidis, V. Streptococci (MIC 3.1 uM), and P. aeruginosa (MIC 12.5 uM).

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 12.5 µM

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source Antifungipept

Other

Evidence Text

IC 50 uM), S. aureus, S. saprophyticus, S. epidermidis, V. Streptococci (MIC 3.1 uM), and P. aeruginosa (MIC 12.5 uM).

Evidence 11 Activity

Activity

Activity Endpoint 20% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 50 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

20% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

The Spider Venom Peptide Lycosin-II Has Potent Antimicrobial Activity against Clinically Isolated Bacteria. | Toxins (Basel) | 2016

Evidence 12 Activity

Activity

Activity Endpoint 3% Cell death

Detail Source Activity Toxicity

Activity Measurement 2 µM

Toxicity Type Cytotoxic

Toxicity Raw

3% Cell death | 2 | µM | target cell: Human foreskin fibroblasts (HFF)

Target

Target Cell Human foreskin fibroblasts (HFF)

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Anti-biofilm and anti-inflammatory effects of Lycosin-II isolated from spiders against multi-drug resistant bacteria. | Biochim Biophys Acta | 2022

Evidence 13 Activity

Activity

Activity Endpoint 5% Cell death

Detail Source Activity Toxicity

Activity Measurement 4 µM

Toxicity Type Cytotoxic

Toxicity Raw

5% Cell death | 4 | µM | target cell: Human foreskin fibroblasts (HFF)

Target

Target Cell Human foreskin fibroblasts (HFF)

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Anti-biofilm and anti-inflammatory effects of Lycosin-II isolated from spiders against multi-drug resistant bacteria. | Biochim Biophys Acta | 2022

Evidence 14 Activity

Activity

Activity Endpoint 47% Cell death

Detail Source Activity Toxicity

Activity Measurement 16 µM

Toxicity Type Cytotoxic

Toxicity Raw

47% Cell death | 16 | µM | target cell: Human foreskin fibroblasts (HFF)

Target

Target Cell Human foreskin fibroblasts (HFF)

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Anti-biofilm and anti-inflammatory effects of Lycosin-II isolated from spiders against multi-drug resistant bacteria. | Biochim Biophys Acta | 2022

Evidence 15 Activity

Activity

Activity Endpoint <5% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 16 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

<5% Hemolysis | 16 | µM | target cell: Sheep erythrocytes

Target

Target Cell Sheep erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Anti-biofilm and anti-inflammatory effects of Lycosin-II isolated from spiders against multi-drug resistant bacteria. | Biochim Biophys Acta | 2022

Evidence 16 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

Hemolytic_activity: Not available | Cytotoxicity: IC50 on PBMCs was = 92.0 ± 39.6 µM

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Evidence 17 Hemolysis

Source & Reference

source APD_complete APD_hemolytic PD_Hemolysis

Database Source APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.