Back to search

Peptide record

TPDB09786

Antibacterial Antifungal Hemolysis Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB09786
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb PD_Hemolysis ToxinPred 3.0
standard
No
A 21-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GWLDVAKKIGKAAFNVAKNFI
Physicochemical Analysis
C109H172N28O26
RCEQHMPSTY
AK
2290.74
10.55
4
1
12
+3
0.22
0.295
102.38
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
240.10
2
Residue Composition
number
4
A
0
R
2
N
1
D
0
C
0
E
0
Q
2
G
0
H
2
I
1
L
4
K
0
M
2
F
0
P
0
S
0
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 4 R: 0 N: 2 D: 1 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 2 L: 1 K: 4 M: 0 F: 2 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 2
Chemical Descriptors
21
C109H172N28O26
2290.74
10.55
+3
0.22
0.295
Evidence Records 10 records
Evidence 1 Activity

Activity

HC50
Hemolysis
26 µM
[Ref.22519531]HC50=26 µmol/L against human red blood cells

Target

human red blood cells

Source & Reference

Hemolytik PD_Hemolysis
DRAMP4
Protein Pept Lett. 2012 Jun 1 19(6):596-603.

Other

Source Activity Label Source Definition
Hemolysis
Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 2 Activity

Activity

HC50
Hemolysis
18.7 µM
[Ref.22519531]HC50=18.7 µmol/L against human red blood cells

Target

human red blood cells

Source & Reference

Hemolytik PD_Hemolysis
DRAMP4
Protein Pept Lett. 2012 Jun 1 19(6):596-603.
Evidence 3 Activity

Activity

HC50
Hemolysis
43.1 µM
[Ref.22519531]HC50=43.1 µmol/L against human red blood cells

Target

human red blood cells

Source & Reference

Hemolytik PD_Hemolysis
DRAMP4
Protein Pept Lett. 2012 Jun 1 19(6):596-603.
Evidence 4 Activity

Activity

50% Hemolysis
Toxicity
26 µM
Hemolytic Cytotoxic
50% Hemolysis | 26 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Mechanism of action and relationship between structure and biological activity of Ctx-Ha: a new ceratotoxin-like peptide from Hypsiboas albopunctatus. | Protein Pept Lett | 2012
Evidence 5 Activity

Activity

HC50
Toxicity
26 µm
Hemolytic
Hemolytic_activity: [Ref.22519531]HC50=26 µmol/L against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Protein Pept Lett. 2012 Jun 1 19(6):596-603.
Evidence 6 Activity

Activity

HC50
Toxicity
18.7 µm
Hemolytic
Hemolytic_activity: [Ref.22519531]HC50=18.7 µmol/L against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Protein Pept Lett. 2012 Jun 1 19(6):596-603.
Evidence 7 Activity

Activity

HC50
Toxicity
43.1 µm
Hemolytic
Hemolytic_activity: [Ref.22519531]HC50=43.1 µmol/L against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Protein Pept Lett. 2012 Jun 1 19(6):596-603.
Evidence 8 Hemolysis

Activity

26 µM
HC50
[Ref.22519531]HC50=26 µmol/L against human red blood cells
Hemolysis

Target

human red blood cells

Source & Reference

PD_Hemolysis
Protein Pept Lett. 2012 Jun 1 19(6):596-603.
DRAMP4
PD_Hemolysis
Evidence 9 Hemolysis

Activity

18.7 µM
HC50
[Ref.22519531]HC50=18.7 µmol/L against human red blood cells
Hemolysis

Target

human red blood cells

Source & Reference

PD_Hemolysis
Protein Pept Lett. 2012 Jun 1 19(6):596-603.
DRAMP4
PD_Hemolysis
Evidence 10 Hemolysis

Activity

43.1 µM
HC50
[Ref.22519531]HC50=43.1 µmol/L against human red blood cells
Hemolysis

Target

human red blood cells

Source & Reference

PD_Hemolysis
Protein Pept Lett. 2012 Jun 1 19(6):596-603.
DRAMP4
PD_Hemolysis