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Peptide record

TPDB09786

Antibacterial Antifungal Hemolysis Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB09786
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb PD_Hemolysis ToxinPred 3.0
standard
No
A 21-aa standard-residue multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GWLDVAKKIGKAAFNVAKNFI
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C109H172N28O26
RCEQHMPSTY
AK
2290.74
10.55
4
1
12
+3
0.19
0.295
102.38
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
2.40
2
Residue Composition
number
4
A
0
R
2
N
1
D
0
C
0
E
0
Q
2
G
0
H
2
I
1
L
4
K
0
M
2
F
0
P
0
S
0
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 4 R: 0 N: 2 D: 1 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 2 L: 1 K: 4 M: 0 F: 2 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 2
Chemical Descriptors
21 reviewed residue count
C109H172N28O26 sequence-only estimate (linear, free termini)
2290.74 sequence-only estimate (linear, free termini)
10.55 sequence-only estimate (linear, free termini)
+3 sequence-only estimate (linear, free termini)
0.19 sequence-only estimate (linear, free termini)
0.295 sequence-only estimate (linear, free termini)
Evidence Records 10 records
Evidence 1 Activity

Activity

HC50
Hemolysis
26 µM
[Ref.22519531]HC50=26 µmol/L against human red blood cells

Target

human red blood cells

Source & Reference

Hemolytik PD_Hemolysis
DRAMP4
Protein Pept Lett. 2012 Jun 1 19(6):596-603.

Other

Source Activity Label Source Definition
Hemolysis
Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 2 Activity

Activity

HC50
Hemolysis
18.7 µM
[Ref.22519531]HC50=18.7 µmol/L against human red blood cells

Target

human red blood cells

Source & Reference

Hemolytik PD_Hemolysis
DRAMP4
Protein Pept Lett. 2012 Jun 1 19(6):596-603.
Evidence 3 Activity

Activity

HC50
Hemolysis
43.1 µM
[Ref.22519531]HC50=43.1 µmol/L against human red blood cells

Target

human red blood cells

Source & Reference

Hemolytik PD_Hemolysis
DRAMP4
Protein Pept Lett. 2012 Jun 1 19(6):596-603.
Evidence 4 Activity

Activity

50% Hemolysis
Toxicity
26 µM
Hemolytic Cytotoxic
50% Hemolysis | 26 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Mechanism of action and relationship between structure and biological activity of Ctx-Ha: a new ceratotoxin-like peptide from Hypsiboas albopunctatus. | Protein Pept Lett | 2012
Evidence 5 Activity

Activity

HC50
Toxicity
26 µm
Hemolytic
Hemolytic_activity: [Ref.22519531]HC50=26 µmol/L against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Protein Pept Lett. 2012 Jun 1 19(6):596-603.
Evidence 6 Activity

Activity

HC50
Toxicity
18.7 µm
Hemolytic
Hemolytic_activity: [Ref.22519531]HC50=18.7 µmol/L against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Protein Pept Lett. 2012 Jun 1 19(6):596-603.
Evidence 7 Activity

Activity

HC50
Toxicity
43.1 µm
Hemolytic
Hemolytic_activity: [Ref.22519531]HC50=43.1 µmol/L against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Protein Pept Lett. 2012 Jun 1 19(6):596-603.
Evidence 8 Hemolysis

Activity

26 µM
HC50
[Ref.22519531]HC50=26 µmol/L against human red blood cells
Hemolysis

Target

human red blood cells

Source & Reference

PD_Hemolysis
Protein Pept Lett. 2012 Jun 1 19(6):596-603.
DRAMP4
PD_Hemolysis
Evidence 9 Hemolysis

Activity

18.7 µM
HC50
[Ref.22519531]HC50=18.7 µmol/L against human red blood cells
Hemolysis

Target

human red blood cells

Source & Reference

PD_Hemolysis
Protein Pept Lett. 2012 Jun 1 19(6):596-603.
DRAMP4
PD_Hemolysis
Evidence 10 Hemolysis

Activity

43.1 µM
HC50
[Ref.22519531]HC50=43.1 µmol/L against human red blood cells
Hemolysis

Target

human red blood cells

Source & Reference

PD_Hemolysis
Protein Pept Lett. 2012 Jun 1 19(6):596-603.
DRAMP4
PD_Hemolysis