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Peptide record

TPDB09772

Antibacterial Anticancer Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB09772
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 21-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GLFKKLRRKIKKGFKKIFKRL
Physicochemical Analysis
C127H222N38O22
ANDCEQHMPSTWYV
K
2633.40
12.73
11
0
8
+11
4.68
-0.795
92.86
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
3
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
2
I
3
L
8
K
0
M
3
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 2 L: 3 K: 8 M: 0 F: 3 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
21
C127H222N38O22
2633.40
12.73
+11
4.68
-0.795
Evidence Records 7 records
Evidence 1 Activity

Activity

MIC
Antibacterial
1.6-3.9 µM

Target

A. baumannii ATCC 9955 or ATCC BAA-1794

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
active against A. baumannii ATCC 9955 or ATCC BAA-1794 (MIC 1.6-3.9 uM), E-faecalis ATCC 22192 or 51299 (MIC > 16 uM), E. coli ATCC 4157 (MIC 7.9-53 uM), K. pneu
Evidence 2 Activity

Activity

MIC
Antibacterial
7.9-53 µM

Target

Escherichia coli ATCC 4157

Source & Reference

dbAMP DRAMP

Other

TCC 9955 or ATCC BAA-1794 (MIC 1.6-3.9 uM), E-faecalis ATCC 22192 or 51299 (MIC > 16 uM), E. coli ATCC 4157 (MIC 7.9-53 uM), K. pneumoniae ATCC 33495 or ATCC BAA-1705 (MIC 2.0-11.0 uM), P. aeruginosa ATCC 9027 or
Evidence 3 Activity

Activity

MIC
Antibacterial
2.0-11.0 µM

Target

Klebsiella pneumoniae ATCC 33495 or ATCC BAA-1705

Source & Reference

dbAMP DRAMP

Other

3.9 uM), E-faecalis ATCC 22192 or 51299 (MIC > 16 uM), E. coli ATCC 4157 (MIC 7.9-53 uM), K. pneumoniae ATCC 33495 or ATCC BAA-1705 (MIC 2.0-11.0 uM), P. aeruginosa ATCC 9027 or ATCC BAA-2110 (MIC 3.9-16 uM), and S. aureus ATCC 25923 or 33
Evidence 4 Activity

Activity

MIC
Antibacterial
3.9-16 µM

Target

Pseudomonas aeruginosa ATCC 9027 or ATCC BAA-2110

Source & Reference

dbAMP DRAMP

Other

i ATCC 4157 (MIC 7.9-53 uM), K. pneumoniae ATCC 33495 or ATCC BAA-1705 (MIC 2.0-11.0 uM), P. aeruginosa ATCC 9027 or ATCC BAA-2110 (MIC 3.9-16 uM), and S. aureus ATCC 25923 or 33592 (MIC 11 uM).
Evidence 5 Activity

Activity

MIC
Antibacterial
11 µM

Target

Staphylococcus aureus ATCC 25923 or 33592

Source & Reference

dbAMP DRAMP

Other

BAA-1705 (MIC 2.0-11.0 uM), P. aeruginosa ATCC 9027 or ATCC BAA-2110 (MIC 3.9-16 uM), and S. aureus ATCC 25923 or 33592 (MIC 11 uM).
Evidence 6 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Cathelicidin antimicrobial peptide from Alligator mississippiensis has antibacterial activity against multi-drug resistant Acinetobacter baumanii and Klebsiella pneumoniae. | Dev Comp Immunol | 2017
Evidence 7 Activity

Activity

% Hemolysis
Toxicity
0.5 %
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.28089718] 0.5% hemolysis at 300µg/ml against sheep red cells | Cytotoxicity: [Ref.28089718] The survival rate of A549 human lung epithelial cells is 113% at a peptide concentration of 300 µg/ml

Target

erythrocytes

Source & Reference

NA
DRAMP
Dev Comp Immunol. 2017 May 70:135-144.