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Peptide record

TPDB09769

Antibacterial Antifungal Hemolysis Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB09769
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP PD_Hemolysis
standard
No
A 21-aa standard-residue multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
GIWKTIKSMGKVFAGAILQNL
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C106H175N27O26S1
RDCEHPY
GIK
2275.78
10.84
3
0
11
+3
-0.38
0.538
116.19
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
2.42
4
Residue Composition
number
2
A
0
R
1
N
0
D
0
C
0
E
1
Q
3
G
0
H
3
I
2
L
3
K
1
M
1
F
0
P
1
S
1
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 1 G: 3 H: 0 I: 3 L: 2 K: 3 M: 1 F: 1 P: 0 S: 1 T: 1 W: 1 Y: 0 V: 1
Chemical Descriptors
21 reviewed residue count
C106H175N27O26S1 sequence-only estimate (linear, free termini)
2275.78 sequence-only estimate (linear, free termini)
10.84 sequence-only estimate (linear, free termini)
+3 sequence-only estimate (linear, free termini)
-0.38 sequence-only estimate (linear, free termini)
0.538 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
40 µM
Hemolytic Cytotoxic
50% Hemolysis | 40 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial properties of brevinin-2-related peptide and its analogs: Efficacy against multidrug-resistant Acinetobacter baumannii | Chem Biol Drug Des | 2009
Evidence 2 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis