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Peptide record

TPDB09767

Antibacterial Antifungal Hemolysis Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB09767
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP PD_Hemolysis
standard
No
A 21-aa standard-residue multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
GIWDTIKSMGKVFAGAILQNL
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C104H168N26O28S1
RCEHPY
GI
2262.70
9.88
2
1
11
+1
-0.23
0.557
116.19
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
2.43
4
Residue Composition
number
2
A
0
R
1
N
1
D
0
C
0
E
1
Q
3
G
0
H
3
I
2
L
2
K
1
M
1
F
0
P
1
S
1
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 1 C: 0 E: 0 Q: 1 G: 3 H: 0 I: 3 L: 2 K: 2 M: 1 F: 1 P: 0 S: 1 T: 1 W: 1 Y: 0 V: 1
Chemical Descriptors
21 reviewed residue count
C104H168N26O28S1 sequence-only estimate (linear, free termini)
2262.70 sequence-only estimate (linear, free termini)
9.88 sequence-only estimate (linear, free termini)
+1 sequence-only estimate (linear, free termini)
-0.23 sequence-only estimate (linear, free termini)
0.557 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
20 µM
Hemolytic Cytotoxic
50% Hemolysis | 20 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial properties of brevinin-2-related peptide and its analogs: Efficacy against multidrug-resistant Acinetobacter baumannii | Chem Biol Drug Des | 2009
Evidence 2 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis