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Peptide record

TPDB09763

Antibacterial Hemolysis Toxicity standard

21 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB09763

Activity

Antibacterial Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia PD_Hemolysis

Sequence_Type

standard

Has_Modification No

Description A 21-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, and PD_Hemolysis, with an available 3D structural model.

Sequence

FWGALAKGALKLIPSLVSSFT

FASTA

>TPDB09763|Antibacterial;Hemolysis;Toxicity|length=21
FWGALAKGALKLIPSLVSSFT

Formula C107H168N24O26

Absent Amino Acids RNDCEQHMY

Common Amino Acids L

Mass 2206.66

PI 10.60

Basic Residues 2

Acidic Residues 0

Hydrophobic Residues 12

Net Charge +2

Boman Index -4.12

Hydrophobicity 0.986

Aliphatic Index 120.95

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 5500

Absorbance 280nm 249.25

Polar Residues 4

number

Amino Acid Distribution

A: 3 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 4 K: 2 M: 0 F: 2 P: 1 S: 3 T: 1 W: 1 Y: 0 V: 1

Length

Formula

C107H168N24O26

Mass

2206.66

10.60

Net Charge

Boman Index

-4.12

Hydrophobicity

0.986

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6.9 µM

Target

Target Organism Staphylococcus aureus AB 94004

Source & Reference

Database Source NA

Other

Evidence Text

Active against Gram+ S. aureus AB 94004 (MIC 6.9 uM) B. megaterium AB 90008 (MIC 1.5 uM) M. luteus AB2010179 (MIC 1.5 uM) Gram- E. coli DH5

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.5 µM

Target

Target Organism B. megaterium AB 90008

Source & Reference

Database Source NA

Other

Evidence Text

Active against Gram+ S. aureus AB 94004 (MIC 6.9 uM) B. megaterium AB 90008 (MIC 1.5 uM) M. luteus AB2010179 (MIC 1.5 uM) Gram- E. coli DH5alpha (MIC 40 uM), P-fluorences PF (M

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.5 µM

Target

Target Organism M. luteus AB2010179

Source & Reference

Database Source NA

Other

Evidence Text

ctive against Gram+ S. aureus AB 94004 (MIC 6.9 uM) B. megaterium AB 90008 (MIC 1.5 uM) M. luteus AB2010179 (MIC 1.5 uM) Gram- E. coli DH5alpha (MIC 40 uM), P-fluorences PF (MIC >50.5 uM), P. putida PP (MIC 35

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 40 µM

Target

Target Organism Escherichia coli DH5alpha

Source & Reference

Database Source NA

Other

Evidence Text

MIC 6.9 uM) B. megaterium AB 90008 (MIC 1.5 uM) M. luteus AB2010179 (MIC 1.5 uM) Gram- E. coli DH5alpha (MIC 40 uM), P-fluorences PF (MIC >50.5 uM), P. putida PP (MIC 35 uM), E-cloacae AB 2010162 (MIC >45

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 35 µM

Target

Target Organism P. putida PP

Source & Reference

Database Source NA

Other

Evidence Text

2010179 (MIC 1.5 uM) Gram- E. coli DH5alpha (MIC 40 uM), P-fluorences PF (MIC >50.5 uM), P. putida PP (MIC 35 uM), E-cloacae AB 2010162 (MIC >45 uM), S. enterica AB 2010185 (MIC 40 uM), K-oxytoca AB 2010

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 40 µM

Target

Target Organism S. enterica AB 2010185

Source & Reference

Database Source NA

Other

Evidence Text

luorences PF (MIC >50.5 uM), P. putida PP (MIC 35 uM), E-cloacae AB 2010162 (MIC >45 uM), S. enterica AB 2010185 (MIC 40 uM), K-oxytoca AB 2010143 (MIC>45 uM), and E-cloacae AB 2010162 (MIC>45 uM).

Evidence 7 Activity

Activity

Activity Endpoint 0% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 0.8 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

0% Hemolysis | 0.8 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Genomic and functional characterization of three new venom peptides from the scorpion Heterometrus spinifer. | Peptides | 2014

Evidence 8 Activity

Activity

Activity Endpoint 1.5% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 1.6 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

1.5% Hemolysis | 1.6 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Genomic and functional characterization of three new venom peptides from the scorpion Heterometrus spinifer. | Peptides | 2014

Evidence 9 Activity

Activity

Activity Endpoint 22.1% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 3.2 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

22.1% Hemolysis | 3.2 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Genomic and functional characterization of three new venom peptides from the scorpion Heterometrus spinifer. | Peptides | 2014

Evidence 10 Activity

Activity

Activity Endpoint 50.1% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 6.4 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50.1% Hemolysis | 6.4 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Genomic and functional characterization of three new venom peptides from the scorpion Heterometrus spinifer. | Peptides | 2014

Evidence 11 Hemolysis

Source & Reference

source PD_Hemolysis

Database Source PD_Hemolysis