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Peptide record

TPDB09758

Antibacterial Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB09758
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 21-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
KWKVFKKIEKMGRNIRNGIVK
Physicochemical Analysis
C118H202N36O26S1
ADCQHLPSTY
K
2573.19
11.72
8
1
8
+7
6.44
-0.857
83.33
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
213.74
2
Residue Composition
number
0
A
2
R
2
N
0
D
0
C
1
E
0
Q
2
G
0
H
3
I
0
L
6
K
1
M
1
F
0
P
0
S
0
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 2 N: 2 D: 0 C: 0 E: 1 Q: 0 G: 2 H: 0 I: 3 L: 0 K: 6 M: 1 F: 1 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 2
Chemical Descriptors
21
C118H202N36O26S1
2573.19
11.72
+7
6.44
-0.857
Evidence Records 3 records
Evidence 1 Activity

Activity

<1% Hemolysis
Toxicity
>250 µM
Hemolytic Cytotoxic
<1% Hemolysis | >250 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Tuneable poration: host defense peptides as sequence probes for antimicrobial mechanisms | Sci Rep | 2018
Evidence 2 Activity

Activity

18% Killing
Toxicity
125 µg/mL
Cytotoxic
18% Killing | 125 | µg/mL | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Systematic comparison of activity and mechanism of antimicrobial peptides against nosocomial pathogens. | Eur J Med Chem | 2022
Evidence 3 Activity

Activity

38% Killing
Toxicity
250 µg/mL
Cytotoxic
38% Killing | 250 | µg/mL | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Systematic comparison of activity and mechanism of antimicrobial peptides against nosocomial pathogens. | Eur J Med Chem | 2022