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Peptide record

TPDB09747

Antibacterial Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB09747
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 21-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
WPKWWKWKRRWGRKKAKKRRG
Physicochemical Analysis
C139H214N48O22
NDCEQHILMFSTYV
K
2909.54
13.01
12
0
6
+12
2.03
-2.614
4.76
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
27500
945.17
0
Residue Composition
number
1
A
5
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
0
I
0
L
7
K
0
M
0
F
1
P
0
S
0
T
5
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 5 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 7 M: 0 F: 0 P: 1 S: 0 T: 0 W: 5 Y: 0 V: 0
Chemical Descriptors
21
C139H214N48O22
2909.54
13.01
+12
2.03
-2.614
Evidence Records 2 records
Evidence 1 Activity

Activity

Toxicity
Hemolytic
NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity of de novo designed cationic peptides against multi-resistant clinical isolates. | Eur J Med Chem | 2014
Evidence 2 Activity

Activity

3.4% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
3.4% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Unravelling the mechanism of action of "de novo" designed peptide P1 with model membranes and gram-positive and gram-negative bacteria. | Arch Biochem Biophys | 2020