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Peptide record

TPDB09745

Antibacterial Anticancer Antifungal Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB09745
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb dbAMP
standard
No
A 21-aa standard-residue multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, DRAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
TQQAFQKFLAAVTSALGKQYH
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C107H165N29O30
RNDCEIMPW
AQ
2337.66
10.20
3
0
10
+2
0.88
-0.205
70.00
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
1490
0.64
8
Residue Composition
number
4
A
0
R
0
N
0
D
0
C
0
E
4
Q
1
G
1
H
0
I
2
L
2
K
0
M
2
F
0
P
1
S
2
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 4 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 4 G: 1 H: 1 I: 0 L: 2 K: 2 M: 0 F: 2 P: 0 S: 1 T: 2 W: 0 Y: 1 V: 1
Chemical Descriptors
21 reviewed residue count
C107H165N29O30 sequence-only estimate (linear, free termini)
2337.66 sequence-only estimate (linear, free termini)
10.20 sequence-only estimate (linear, free termini)
+2 sequence-only estimate (linear, free termini)
0.88 sequence-only estimate (linear, free termini)
-0.205 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

0% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial function of SH?AP, a novel hemoglobin ? chain-related antimicrobial peptide, isolated from the liver of skipjack tuna, Katsuwonus pelamis. | Fish Shellfish Immunol | 2014
Evidence 2 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.24495783]not cause hemolysis against RBCs up to 100 µg/mL concentration.

Target

erythrocytes

Source & Reference

NA
DRAMP
Fish Shellfish Immunol. 2014 Mar 37(1):173-83.