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Peptide record

TPDB09743

Antibacterial Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB09743
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 21-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
RWCVYAYRRVRGVLVRYRRCW
Physicochemical Analysis
C128H198N44O25S2
NDEQHIKMFPST
R
2817.38
11.66
7
0
11
+7
-1.77
-0.486
78.57
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
15595
553.53
5
Residue Composition
number
1
A
7
R
0
N
0
D
2
C
0
E
0
Q
1
G
0
H
0
I
1
L
0
K
0
M
0
F
0
P
0
S
0
T
2
W
3
Y
4
V
Amino Acid Distribution
A: 1 R: 7 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 3 V: 4
Chemical Descriptors
21
C128H198N44O25S2
2817.38
11.66
+7
-1.77
-0.486
Evidence Records 3 records
Evidence 1 Activity

Activity

MIC
Antibacterial
6.25 µM

Target

Staphylococcus aureus strain 209P

Source & Reference

NA

Other

Active against S. aureus strain 209P (MIC 6.25 uM), E. coli strain C600 (1.56 uM), and P. aeruginosa PAO1 (MIC 1.56 uM).
Evidence 2 Activity

Activity

MIC
Antibacterial
1.56 µM

Target

Pseudomonas aeruginosa PAO1

Source & Reference

NA

Other

Active against S. aureus strain 209P (MIC 6.25 uM), E. coli strain C600 (1.56 uM), and P. aeruginosa PAO1 (MIC 1.56 uM).
Evidence 3 Activity

Activity

10% Hemolysis
Toxicity
125.0 µM
Hemolytic Cytotoxic
10% Hemolysis | 125.0 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design of antimicrobial peptide arenicin analogs with improved therapeutic indices. | J Pept Sci | 2015