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Peptide record

TPDB09720

Antibacterial Antifungal Hemolysis Toxicity standard

21 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB09720

Activity

Antibacterial Antifungal Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia Antifungipept APD_complete HemoPI Hemolytic2 PD_Hemolysis

Sequence_Type

standard

Has_Modification No

Description A 21-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.

Sequence

KWKLFKKIFKRIVQRIKDFLR

FASTA

>TPDB09720|Antibacterial;Antifungal;Hemolysis;Toxicity|length=21
KWKLFKKIFKRIVQRIKDFLR

Formula C136H224N38O25

Absent Amino Acids ANCEGHMPSTY

Common Amino Acids K

Mass 2791.51

PI 12.18

Basic Residues 9

Acidic Residues 1

Hydrophobic Residues 10

Net Charge +8

Boman Index 2.96

Hydrophobicity -0.529

Aliphatic Index 106.67

Half Life

Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 5500

Absorbance 280nm 197.03

Polar Residues 1

number

Amino Acid Distribution

A: 0 R: 3 N: 0 D: 1 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 3 L: 2 K: 6 M: 0 F: 3 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 1

Length

Formula

C136H224N38O25

Mass

2791.51

12.18

Net Charge

Boman Index

2.96

Hydrophobicity

-0.529

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 7.8 ug/mL

Target

Target Organism B. anthracis spores

Source & Reference

Database Source NA

Other

Evidence Text

Active against B. anthracis spores (MIC 7.8 ug/mL), B. anthracis vegetative (MIC 31.3 ug/mL), and gram- B. cepacia (MIC 31.3 ug/mL). Updated

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 31.3 ug/mL

Target

Target Organism B. anthracis vegetative

Source & Reference

Database Source NA

Other

Evidence Text

Active against B. anthracis spores (MIC 7.8 ug/mL), B. anthracis vegetative (MIC 31.3 ug/mL), and gram- B. cepacia (MIC 31.3 ug/mL). Updated 7/2021

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 31.3 ug/mL

Target

Target Organism B. cepacia

Source & Reference

Database Source NA

Other

Evidence Text

B. anthracis spores (MIC 7.8 ug/mL), B. anthracis vegetative (MIC 31.3 ug/mL), and gram- B. cepacia (MIC 31.3 ug/mL). Updated 7/2021

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 7.8 ug/mL

Target

Target Organism B. anthracis spores

Source & Reference

Database Source Antifungipept

Other

Evidence Text

Active against B. anthracis spores (MIC 7.8 ug/mL), B. anthracis vegetative (MIC 31.3 ug/mL), and gram- B. cepacia (MIC 31.3 ug/mL). Updated

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 31.3 ug/mL

Target

Target Organism B. anthracis vegetative

Source & Reference

Database Source Antifungipept

Other

Evidence Text

Active against B. anthracis spores (MIC 7.8 ug/mL), B. anthracis vegetative (MIC 31.3 ug/mL), and gram- B. cepacia (MIC 31.3 ug/mL). Updated 7/2021

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 31.3 ug/mL

Target

Target Organism B. cepacia

Source & Reference

Database Source Antifungipept

Other

Evidence Text

B. anthracis spores (MIC 7.8 ug/mL), B. anthracis vegetative (MIC 31.3 ug/mL), and gram- B. cepacia (MIC 31.3 ug/mL). Updated 7/2021

Evidence 7 Activity

Activity

Activity Endpoint 100% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 100 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

100% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Potent antimicrobial peptides with selectivity for Bacillus anthracis over human erythrocytes. | Int J Antimicrob Agents | 2011

Evidence 8 Activity

Activity

Activity Endpoint 90% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 15.6 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

90% Hemolysis | 15.6 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Design and characterization of novel hybrid antimicrobial peptides based on cecropin A, LL-37 and magainin II. | Peptides | 2012

Evidence 9 Hemolysis

Source & Reference

source APD_complete HemoPI PD_Hemolysis

Database Source APD_complete PD_Hemolysis

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation.