Peptide record

TPDB09714

Chariot Pep-1 (Chariot) PEP-1 PTD peptide Pep1-BoNTA PEP-1 PEP1 Antibacterial Anticancer Cell-penetrating Peptides Toxicity standard

21 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB09714

Peptide_Name

Chariot Pep-1 (Chariot) PEP-1 PTD peptide Pep1-BoNTA PEP-1 PEP1

Activity

Antibacterial Anticancer Cell-penetrating Peptides Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia CellPPD CellPPD-MOD CPPsite3.0 PerseuCPP

Sequence_Type

standard

Has_Modification No

Description A 21-aa standard natural multi-activity (Antibacterial, Anticancer, Cell-penetrating Peptides, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

KETWWETWWTEWSQPKKKRKV

FASTA

>TPDB09714|Antibacterial;Anticancer;Cell-penetrating Peptides;Toxicity|length=21
KETWWETWWTEWSQPKKKRKV

Formula C136H195N35O33

Absent Amino Acids ANDCGHILMFY

Common Amino Acids KW

Mass 2848.26

PI 10.38

Basic Residues 6

Acidic Residues 3

Hydrophobic Residues 6

Net Charge +3

Boman Index 4.22

Hydrophobicity -2.038

Aliphatic Index 13.81

Half Life

Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 27500

Absorbance 280nm 965.50

Polar Residues 5

number

Amino Acid Distribution

A: 0 R: 1 N: 0 D: 0 C: 0 E: 3 Q: 1 G: 0 H: 0 I: 0 L: 0 K: 5 M: 0 F: 0 P: 1 S: 1 T: 3 W: 5 Y: 0 V: 1

Length

Formula

C136H195N35O33

Mass

2848.26

10.38

Net Charge

Boman Index

4.22

Hydrophobicity

-2.038

C_terminal_Modification

Free

Chirality

Ionic_State

Amphipathic Cationic

Linearity

Linear

N_terminal_Modification

Free

SMILES

N[C@@H](CCCCN)C(=O)N[C@H](CCC(=O)O)C(=O)N[C@@H]([C@H](C)O)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H]([C@H](C)O)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@H]([C@H](C)O)C(=O)N[C@H](CCC(=O)O)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@H](CO)C(=O)N[C@@H](CCC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(C)C)C1OO1 N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O N[C@@H](CS)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)O N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)O N[C@@H](Cc1ccccc1)C(=O)/N=C/C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)O N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)O N[C@@H](CS)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CS)C(=O)O N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)O

Evidence 1 Activity

Activity

Detail Source Activity Antibacterial

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

active against C. trachomatis demonstrated in vitro.

Evidence 2 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line CT26 mouse colon cancer cells, HeLa and Hep3B cells

Assay & Model

In Vitro Model Male Balb/c mice

In Vivo Model Male Balb/c mice

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

Source Activity Label	Source Definition
Cell-penetrating Peptides	CPPsite3.0 experimentally validated cell-penetrating peptide annotation.

CPP Category Natural residues Linear L

Source of Peptide Synthetic

Cargo Type Peptide (Mitochondrial Target Domain of NOXA)

Uptake Efficiency Lower uptake efficiency

In Vitro or In Vivo In vitro and in vivo

DSSP Secondary Structure CCSSCCCCCCCCCCCSSCCCC

Evidence 3 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line Vero Cells And Hk-2 Cells

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L

Cargo Type Copper/zinc superoxide dismutase (SOD1)

In Vitro or In Vivo In vitro

DSSP Secondary Structure CCSSCCCCCCCCCCCSSCCCC

Evidence 4 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line HeLa Cells

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L Amphipathic

Source of Peptide Synthetic

Cargo Type FITC-labeled

Subcellular Localization Cytosol, Nucleus and Endosomes

Uptake Efficiency Display highest fluorescence intensities

In Vitro or In Vivo In vitro

DSSP Secondary Structure CCCCCCCC

Evidence 5 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line Ins-1 Cells

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L Amphipathic

Source of Peptide Synthetic

Cargo Type Paraoxonase 1 (PON1) enzyme

Subcellular Localization Cytoplasm

Uptake Efficiency Dose- and time-dependent internalization

Uptake Mechanism Transduction

In Vitro or In Vivo In vitro

DSSP Secondary Structure CCGGGTSCC

Evidence 6 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line Human Articular CHOndrocytes

Assay & Model

In Vitro Model 16-week-old maleC57BL/6N mice

In Vivo Model 16-week-old maleC57BL/6N mice

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L Amphipathic

Source of Peptide Synthetic

Cargo Type Glutaredoxin-1 (GRX-1) enzyme

Uptake Efficiency Dose-dependent internalizaion

In Vitro or In Vivo In vitro and in vivo

DSSP Secondary Structure CCCCSSCCSCC

Evidence 7 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line Ht-22 Cells

Assay & Model

In Vitro Model Male gerbils (65–75 g 6 months old)

In Vivo Model Male gerbils (65–75 g 6 months old)

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L Amphipathic

Source of Peptide Synthetic

Cargo Type Glutathione S-transferase alpha 2 (GSTA2) protein

Subcellular Localization Cytoplasm and nucleus

Uptake Efficiency Extensive green fluorescence in PEP-1-GSTA2-treated cells while no fluorescence in cells without PEP-1 peptide

In Vitro or In Vivo In vitro and in vivo

DSSP Secondary Structure CCCCCCCTTCCCCSSSSTTTHIIIIICC

Evidence 8 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Assay & Model

In Vitro Model ICR mice (male, aged 4‐5 weeks weight,21±2 g)

In Vivo Model ICR mice (male, aged 4‐5 weeks weight,21±2 g)

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L Amphipathic

Source of Peptide Fusogenic

Cargo Type Heme oxygenase-1 (HO-1)

In Vitro or In Vivo In vivo

DSSP Secondary Structure CCCCCCC

Evidence 9 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Assay & Model

In Vitro Model ICR mice (male, aged 4‐5 weeks weight,21±2 g)

In Vivo Model ICR mice (male, aged 4‐5 weeks weight,21±2 g)

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L Amphipathic

Source of Peptide Fusogenic

Cargo Type Enhanced green fluorescent protein (EGFP)

In Vitro or In Vivo In vivo

DSSP Secondary Structure CCSSCCCCCCCCCCCSSCCCC

Evidence 10 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line Hek293T And Ct26.Cl25 Cell Lines

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L Amphipathic

Cargo Type 5-methoxyuridine-modified mCherry mRNA, Enhanced green fluorescence protein (EGFP) mRNA and Ovalbumin (OVA) mRNA

Subcellular Localization Cytoplasm

Uptake Efficiency Pep-1 showed a low cellular uptake of 9.72 %,

In Vitro or In Vivo In vitro

DSSP Secondary Structure CCSTTHHHHHHHHHCCHHHHHHTSSCSCC

Evidence 11 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line CHO Dg44 Cells, CHO-Grapfurin Cells And Ht1080 Fibrosarcoma Cells

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L Cationic

Source of Peptide Synthetic

In Vitro or In Vivo In vitro

DSSP Secondary Structure CCTTSSCCCCC

Evidence 12 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line Kf3 Fibroblast Cells

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Non-natural residues Linear L Amphipathic

Source of Peptide Synthetic

Cargo Type (synNF1-eGFP) protein

Subcellular Localization Cytoplasm

Uptake Efficiency SynNF1eGFP was transduced efficiently into the fibroblasts but less than transduction reagent Endo-Porter

Uptake Mechanism Endosomal pathway

In Vitro or In Vivo In vitro

Evidence 13 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line Ai9 Tdtomato Npcs

Assay & Model

In Vitro Model Ai9 or wild-type mice

In Vivo Model Ai9 or wild-type mice

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L

Cargo Type SpyCas9 RNPs

In Vitro or In Vivo In vitro and in vivo

DSSP Secondary Structure CCCCCTTTTCCGGGSSSSCC

Evidence 14 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line Cos-7 Cells

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L Amphipathic

Source of Peptide Synthetic

Cargo Type human epidermal growth factor (hEGF)

Subcellular Localization Cytoplasm and nucleus

Uptake Efficiency Compared with rhEGF, P-EGF was widely distributed on the cell membrane in the cytoplasm and the nucleus.

In Vitro or In Vivo In vitro

DSSP Secondary Structure CCCCCCCC

Evidence 15 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line Nih/3T3, CHO-K1, Or HeLa Cells

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L

Source of Peptide Protein derived

Cargo Type TfAF488 or 0.2-μm microspheres , lentivirus particles carrying the pac gene

Uptake Efficiency PepB2 show greater efficacy than other

In Vitro or In Vivo In vitro

DSSP Secondary Structure CCSCCSSCCSSCCSCC

Evidence 16 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line Sk-Ov-3 Cells

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L Amphipathic

Source of Peptide Protein derived

Cargo Type NfnB-Cys enzyme and AuNPs

Uptake Efficiency Significant enhancement in nanoparticle internalization

In Vitro or In Vivo In vitro

DSSP Secondary Structure CCHHHHGGGCC

Evidence 17 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line N2A Cells

Assay & Model

In Vitro Model Eight week old, C57BL/6J female mice (17–22 g)

In Vivo Model Eight week old, C57BL/6J female mice (17–22 g)

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Non-natural residues Linear L

Source of Peptide Protein derived

Cargo Type Botulinum neurotoxin serotype A (BoNTA)

In Vitro or In Vivo In vitro and in vivo

Evidence 18 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line HaCat and Balb/c 3T3 cells

Assay & Model

In Vitro Model Kunming mice

In Vivo Model Kunming mice

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L Amphipathic

Source of Peptide Protein derived

Cargo Type Hyaluronic acid binding peptide (HaBP)

Uptake Efficiency Pep-1 and HaBP could significantly improve the penetrating action of HA in epidermal cells.

In Vitro or In Vivo In vitro and in vivo

DSSP Secondary Structure CCSHHHHSTTTTSSCSSSTTTTTCCSTHHHHGGGGGSCTTTTTSCCCTTSSCC

Evidence 19 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

- | NA | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Design and mechanism of action of a novel bacteria-selective antimicrobial peptide from the cell-penetrating peptide Pep-1. | Biochem Biophys Res Commun | 2006

Evidence 20 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Toxicity

Activity Measurement >=65 µM

Toxicity Type Cytotoxic

Toxicity Raw

IC50 | >=65 | µM | target cell: Human PBMC

Target

Target Cell Human PBMC

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Selective anticancer activity of synthetic peptides derived from the host defence peptide tritrpticin. | Biochim Biophys Acta | 2020

Evidence 21 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic

Toxicity Raw

Hemolytic_activity: [Ref.16945333]Non-hemolysis at 200 µM against human red blood cells

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Biochem Biophys Res Commun. 2006 Oct 20 349(2):769-74.

DSSP_Secondary_Structure

CCSSCCCCCCCCCCCSSCCCC CCCCCCCC CCGGGTSCC CCCCSSCCSCC CCCCCCCTTCCCCSSSSTTTHIIIIICC CCCCCCC CCSTTHHHHHHHHHCCHHHHHHTSSCSCC CCTTSSCCCCC CCCCCTTTTCCGGGSSSSCC CCSCCSSCCSSCCSCC CCHHHHGGGCC CCSHHHHSTTTTSSCSSSTTTTTCCSTHHHHGGGGGSCTTTTTSCCCTTSSCC