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Peptide record

TPDB09711

Antibacterial Antifungal Antiparasitic Hemolysis Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB09711
Antibacterial Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb dbAMP 3.0 APD_complete PD_Hemolysis ToxinPred 3.0
standard
No
A 21-aa standard natural multi-activity (Antibacterial, Antifungal, Antiparasitic, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GFLDIVKGVGKVALGAVSKLF
Physicochemical Analysis
C101H168N24O25
RNCEQHMPTWY
GV
2118.59
10.32
3
1
12
+2
0.06
1.157
139.05
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
2
A
0
R
0
N
1
D
0
C
0
E
0
Q
4
G
0
H
1
I
3
L
3
K
0
M
2
F
0
P
1
S
0
T
0
W
0
Y
4
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 4 H: 0 I: 1 L: 3 K: 3 M: 0 F: 2 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 4
Chemical Descriptors
21
C101H168N24O25
2118.59
10.32
+2
0.06
1.157
Evidence Records 17 records
Evidence 1 Activity

Activity

IC50
Antibacterial
2.87 µM

Target

T. cruzi Trypomastigotes

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
ctive against E. coli (15.1 uM), S. aureus (3.8 uM), and C. albicans (3.8 uM). Parasites: T. cruzi Trypomastigotes (IC50 2.87 uM) or Amastigotes (IC50 16.72 uM), P. falciparum NF54 (IC50 31.16 uM) or TM90C2B (IC50 16.76
Evidence 2 Activity

Activity

IC50
Antibacterial
31.16 µM

Target

P. falciparum NF54

Source & Reference

dbAMP DRAMP

Other

8 uM). Parasites: T. cruzi Trypomastigotes (IC50 2.87 uM) or Amastigotes (IC50 16.72 uM), P. falciparum NF54 (IC50 31.16 uM) or TM90C2B (IC50 16.76 uM), L. Mexicana (IC50 0.54 uM) ( Proaño-Bolaños et al., 2024 . Up
Evidence 3 Activity

Activity

IC50
Antibacterial
0.54 µM

Target

L. Mexicana

Source & Reference

dbAMP DRAMP

Other

astigotes (IC50 16.72 uM), P. falciparum NF54 (IC50 31.16 uM) or TM90C2B (IC50 16.76 uM), L. Mexicana (IC50 0.54 uM) ( Proaño-Bolaños et al., 2024 . Updated 7/2021 7/2024
Evidence 4 Activity

Activity

IC50
Antifungal
2.87 µM

Target

T. cruzi Trypomastigotes

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
ctive against E. coli (15.1 uM), S. aureus (3.8 uM), and C. albicans (3.8 uM). Parasites: T. cruzi Trypomastigotes (IC50 2.87 uM) or Amastigotes (IC50 16.72 uM), P. falciparum NF54 (IC50 31.16 uM) or TM90C2B (IC50 16.76
Evidence 5 Activity

Activity

IC50
Antifungal
31.16 µM

Target

P. falciparum NF54

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

8 uM). Parasites: T. cruzi Trypomastigotes (IC50 2.87 uM) or Amastigotes (IC50 16.72 uM), P. falciparum NF54 (IC50 31.16 uM) or TM90C2B (IC50 16.76 uM), L. Mexicana (IC50 0.54 uM) ( Proaño-Bolaños et al., 2024 . Up
Evidence 6 Activity

Activity

IC50
Antifungal
0.54 µM

Target

L. Mexicana

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

astigotes (IC50 16.72 uM), P. falciparum NF54 (IC50 31.16 uM) or TM90C2B (IC50 16.76 uM), L. Mexicana (IC50 0.54 uM) ( Proaño-Bolaños et al., 2024 . Updated 7/2021 7/2024
Evidence 7 Activity

Activity

IC50
Antiparasitic
2.87 µM

Target

T. cruzi Trypomastigotes

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.
ctive against E. coli (15.1 uM), S. aureus (3.8 uM), and C. albicans (3.8 uM). Parasites: T. cruzi Trypomastigotes (IC50 2.87 uM) or Amastigotes (IC50 16.72 uM), P. falciparum NF54 (IC50 31.16 uM) or TM90C2B (IC50 16.76
Evidence 8 Activity

Activity

IC50
Antiparasitic
31.16 µM

Target

P. falciparum NF54

Source & Reference

dbAMP 3.0 DRAMP

Other

8 uM). Parasites: T. cruzi Trypomastigotes (IC50 2.87 uM) or Amastigotes (IC50 16.72 uM), P. falciparum NF54 (IC50 31.16 uM) or TM90C2B (IC50 16.76 uM), L. Mexicana (IC50 0.54 uM) ( Proaño-Bolaños et al., 2024 . Up
Evidence 9 Activity

Activity

IC50
Antiparasitic
0.54 µM

Target

L. Mexicana

Source & Reference

dbAMP 3.0 DRAMP

Other

astigotes (IC50 16.72 uM), P. falciparum NF54 (IC50 31.16 uM) or TM90C2B (IC50 16.76 uM), L. Mexicana (IC50 0.54 uM) ( Proaño-Bolaños et al., 2024 . Updated 7/2021 7/2024
Evidence 10 Activity

Activity

9% Hemolysis
Toxicity
16 µg/mL
Hemolytic Cytotoxic
9% Hemolysis | 16 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Peptidomic approach identifies cruzioseptins, a new family of potent antimicrobial peptides in the splendid leaf frog, Cruziohyla calcarifer. | J Proteomics | 2016
Evidence 11 Activity

Activity

20% Hemolysis
Toxicity
32 µg/mL
Hemolytic Cytotoxic
20% Hemolysis | 32 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Peptidomic approach identifies cruzioseptins, a new family of potent antimicrobial peptides in the splendid leaf frog, Cruziohyla calcarifer. | J Proteomics | 2016
Evidence 12 Activity

Activity

33% Hemolysis
Toxicity
64 µg/mL
Hemolytic Cytotoxic
33% Hemolysis | 64 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Peptidomic approach identifies cruzioseptins, a new family of potent antimicrobial peptides in the splendid leaf frog, Cruziohyla calcarifer. | J Proteomics | 2016
Evidence 13 Activity

Activity

62% Hemolysis
Toxicity
128 µg/mL
Hemolytic Cytotoxic
62% Hemolysis | 128 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Peptidomic approach identifies cruzioseptins, a new family of potent antimicrobial peptides in the splendid leaf frog, Cruziohyla calcarifer. | J Proteomics | 2016
Evidence 14 Activity

Activity

100% Hemolysis
Toxicity
256 µg/mL
Hemolytic Cytotoxic
100% Hemolysis | 256 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Peptidomic approach identifies cruzioseptins, a new family of potent antimicrobial peptides in the splendid leaf frog, Cruziohyla calcarifer. | J Proteomics | 2016
Evidence 15 Activity

Activity

1% Hemolysis
Toxicity
8 µg/mL
Hemolytic Cytotoxic
1% Hemolysis | 8 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Peptidomic approach identifies cruzioseptins, a new family of potent antimicrobial peptides in the splendid leaf frog, Cruziohyla calcarifer. | J Proteomics | 2016
Evidence 16 Activity

Activity

50% Cytotoxicity
Toxicity
112.34±0.2 µM
Cytotoxic
50% Cytotoxicity | 112.34±0.2 | µM | target cell: Bone marrow-derived macrophages (BMDMs)

Target

Bone marrow-derived macrophages (BMDMs)

Source & Reference

NA
DBAASP
Cruzioseptins, antibacterial peptides from Cruziohyla calcarifer skin, as promising leishmanicidal agents. | Pathog Dis | 2020
Evidence 17 Hemolysis

Source & Reference

APD_complete PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.