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Peptide record

TPDB09709

Antibacterial Cell-penetrating Peptides Hemolysis Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB09709
Antibacterial Cell-penetrating Peptides Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 dbAMP DRAMP Peptipedia CPPsite3.0 PD_Hemolysis
standard
No
A 21-aa standard natural multi-activity (Antibacterial, Cell-penetrating Peptides, Hemolysis, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KIAGKIAKIAGKIAKIAGKIA
Physicochemical Analysis
C96H179N27O22
RNDCEQHLMFPSTWYV
AIK
2063.64
11.21
6
0
12
+6
3.09
0.629
140.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
6
A
0
R
0
N
0
D
0
C
0
E
0
Q
3
G
0
H
6
I
0
L
6
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 6 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 6 L: 0 K: 6 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
21
C96H179N27O22
2063.64
11.21
+6
3.09
0.629
Evidence Records 12 records
Evidence 1 Activity

Activity

6% Hemolysis
Toxicity
32 µg/mL
Hemolytic Cytotoxic
6% Hemolysis | 32 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Influence of C-terminal amidation on the antimicrobial and hemolytic activities of cationic a-helical peptides | Pure Appl Chem | 2007
Evidence 2 Activity

Activity

8% Hemolysis
Toxicity
128 µg/mL
Hemolytic Cytotoxic
8% Hemolysis | 128 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Influence of C-terminal amidation on the antimicrobial and hemolytic activities of cationic a-helical peptides | Pure Appl Chem | 2007
Evidence 3 Activity

Activity

14% Hemolysis
Toxicity
512 µg/mL
Hemolytic Cytotoxic
14% Hemolysis | 512 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Influence of C-terminal amidation on the antimicrobial and hemolytic activities of cationic a-helical peptides | Pure Appl Chem | 2007
Evidence 4 Activity

Activity

19% Hemolysis
Toxicity
1024 µg/mL
Hemolytic Cytotoxic
19% Hemolysis | 1024 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Influence of C-terminal amidation on the antimicrobial and hemolytic activities of cationic a-helical peptides | Pure Appl Chem | 2007
Evidence 5 Activity

Activity

9% Hemolysis
Toxicity
500 µg/mL
Hemolytic Cytotoxic
9% Hemolysis | 500 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A novel linear amphipathic beta-sheet cationic antimicrobial peptide with enhanced selectivity for bacterial lipids | J Biol Chem | 2001
Evidence 6 Activity

Activity

3% Hemolysis
Toxicity
8 µg/mL
Hemolytic Cytotoxic
3% Hemolysis | 8 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Hydrophobic mismatch demonstrated for membranolytic peptides, and their use as molecular rulers to measure bilayer thickness in native cells. | Sci Rep | 2015
Evidence 7 Activity

Activity

7% Hemolysis
Toxicity
32 µg/mL
Hemolytic Cytotoxic
7% Hemolysis | 32 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Hydrophobic mismatch demonstrated for membranolytic peptides, and their use as molecular rulers to measure bilayer thickness in native cells. | Sci Rep | 2015
Evidence 8 Activity

Activity

15% Hemolysis
Toxicity
128 µg/mL
Hemolytic Cytotoxic
15% Hemolysis | 128 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Hydrophobic mismatch demonstrated for membranolytic peptides, and their use as molecular rulers to measure bilayer thickness in native cells. | Sci Rep | 2015
Evidence 9 Activity

Activity

38% Hemolysis
Toxicity
512 µg/mL
Hemolytic Cytotoxic
38% Hemolysis | 512 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Hydrophobic mismatch demonstrated for membranolytic peptides, and their use as molecular rulers to measure bilayer thickness in native cells. | Sci Rep | 2015
Evidence 10 Activity

Activity

51% Hemolysis
Toxicity
1024 µg/mL
Hemolytic Cytotoxic
51% Hemolysis | 1024 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Influence of C-terminal amidation on the antimicrobial and hemolytic activities of cationic a-helical peptides | Pure Appl Chem | 2007
Evidence 11 Activity

Activity

50% Hemolysis
Toxicity
42 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 42 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Terminal Charges Modulate the Pore Forming Activity of Cationic Amphipathic Helices. | Biochim Biophys Acta | 2020
Evidence 12 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis