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Peptide record

TPDB09679

Antibacterial Antifungal Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB09679
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb
standard
No
A 21-aa standard-residue multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GWLDVAKKKGKAAFNVAKNFI
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C109H173N29O26
RCEQHMPSTY
K
2305.75
10.71
5
1
11
+4
0.69
-0.105
83.81
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
2.39
2
Residue Composition
number
4
A
0
R
2
N
1
D
0
C
0
E
0
Q
2
G
0
H
1
I
1
L
5
K
0
M
2
F
0
P
0
S
0
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 4 R: 0 N: 2 D: 1 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 1 K: 5 M: 0 F: 2 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 2
Chemical Descriptors
21 reviewed residue count
C109H173N29O26 sequence-only estimate (linear, free termini)
2305.75 sequence-only estimate (linear, free termini)
10.71 sequence-only estimate (linear, free termini)
+4 sequence-only estimate (linear, free termini)
0.69 sequence-only estimate (linear, free termini)
-0.105 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
270 µM
Hemolytic Cytotoxic
50% Hemolysis | 270 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Mechanism of action and relationship between structure and biological activity of Ctx-Ha: a new ceratotoxin-like peptide from Hypsiboas albopunctatus. | Protein Pept Lett | 2012
Evidence 2 Activity

Activity

HC50
Toxicity
24.9 µm
Hemolytic
Hemolytic_activity: [Ref.22519531]HC50=24.9 µmol/L against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Protein Pept Lett. 2012 Jun 1 19(6):596-603.