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Peptide record

TPDB09664

Antibacterial Anticancer Antifungal Toxicity standard

20 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB09664

Activity

Antibacterial Anticancer Antifungal Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia CancerPPD 2.0 dbACP AFP-GFuse Antifungipept CAFPdb dbAMP ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 20-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CancerPPD 2.0, and other sources, with an available 3D structural model.

Sequence

FIQHLIPLIPHAIQGIKDIF

FASTA

>TPDB09664|Antibacterial;Anticancer;Antifungal;Toxicity|length=20
FIQHLIPLIPHAIQGIKDIF

Formula C113H177N27O25

Absent Amino Acids RNCEMSTWYV

Common Amino Acids I

Mass 2313.81

PI 7.97

Basic Residues 3

Acidic Residues 1

Hydrophobic Residues 11

Net Charge +0

Boman Index 0.80

Hydrophobicity 0.880

Aliphatic Index 161.00

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 2

number

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 2 G: 1 H: 2 I: 6 L: 2 K: 1 M: 0 F: 2 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

Formula

C113H177N27O25

Mass

2313.81

7.97

Net Charge

Boman Index

0.80

Hydrophobicity

0.880

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 16-32 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

moderately to weakly active against S. aureus (MIC 16-32 uM), MRSA (MIC 32-64 uM), E.faecalis (MIC 128 uM), E.coli (MIC>512 uM), P.aeruginosa (>512 uM

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 128 µM

Target

Target Organism Enterococcus faecalis

Source & Reference

Database Source dbAMP

Other

Evidence Text

moderately to weakly active against S. aureus (MIC 16-32 uM), MRSA (MIC 32-64 uM), E.faecalis (MIC 128 uM), E.coli (MIC>512 uM), P.aeruginosa (>512 uM), and C. albicans (MIC 64-128 uM). Cf. melitt

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >512 µM

Target

Target Organism E.coli

Source & Reference

Database Source dbAMP

Other

Evidence Text

ly active against S. aureus (MIC 16-32 uM), MRSA (MIC 32-64 uM), E.faecalis (MIC 128 uM), E.coli (MIC>512 uM), P.aeruginosa (>512 uM), and C. albicans (MIC 64-128 uM). Cf. melittin (MIC 1-8 uM, mostl

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 64-128 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP

Other

Evidence Text

(MIC 32-64 uM), E.faecalis (MIC 128 uM), E.coli (MIC>512 uM), P.aeruginosa (>512 uM), and C. albicans (MIC 64-128 uM). Cf. melittin (MIC 1-8 uM, mostly). The peptide displayed dose-dependent anticancer effec

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 16-32 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.

Evidence Text

moderately to weakly active against S. aureus (MIC 16-32 uM), MRSA (MIC 32-64 uM), E.faecalis (MIC 128 uM), E.coli (MIC>512 uM), P.aeruginosa (>512 uM

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 128 µM

Target

Target Organism Enterococcus faecalis

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

moderately to weakly active against S. aureus (MIC 16-32 uM), MRSA (MIC 32-64 uM), E.faecalis (MIC 128 uM), E.coli (MIC>512 uM), P.aeruginosa (>512 uM), and C. albicans (MIC 64-128 uM). Cf. melitt

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >512 µM

Target

Target Organism E.coli

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

ly active against S. aureus (MIC 16-32 uM), MRSA (MIC 32-64 uM), E.faecalis (MIC 128 uM), E.coli (MIC>512 uM), P.aeruginosa (>512 uM), and C. albicans (MIC 64-128 uM). Cf. melittin (MIC 1-8 uM, mostl

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 64-128 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 9 Activity

Activity

Activity Endpoint 2.5% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 160 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

2.5% Hemolysis | 160 | µM | target cell: Horse erythrocytes

Target

Target Cell Horse erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

A Novel Antimicrobial Peptide (Kassinatuerin-3) Isolated from the Skin Secretion of the African Frog, Kassina senegalensis. | Biology (Basel) | 2020

Evidence 10 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Cytotoxic

Toxicity Raw

Cytotoxicity: Not available

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Biology (Basel). 2020 Jul 2 9(7):148.