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Peptide record

TPDB09623

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB09623
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 dbACP iACP-DRLF Antifungipept CAFPdb APD_complete APD_hemolytic Hemolytic2
standard
No
A 20-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
LIGPVLGLVGSALGGLLKKI
Physicochemical Analysis
C91H164N22O22
RNDCEQHMFTWY
L
1918.44
10.60
2
0
11
+2
-1.40
1.490
190.00
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
5
G
0
H
2
I
6
L
2
K
0
M
0
F
1
P
1
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 5 H: 0 I: 2 L: 6 K: 2 M: 0 F: 0 P: 1 S: 1 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
20
C91H164N22O22
1918.44
10.60
+2
-1.40
1.490
Evidence Records 11 records
Evidence 1 Activity

Activity

MIC
Antibacterial
8 µM

Target

Corynebacterium jeikeium ATCC BAA-949

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
ureus Cowan I (4.7 uM), S. lentus (2.0 uM), M. luteus (2.0 uM). Also active against Gram+ C. jeikeium ATCC BAA-949 (MIC 8 uM) ( Bruno Casciaro et al., 2020 ). fungi C. albicans ATCC 10231 (3.1 uM), C. guiller-mondii
Evidence 2 Activity

Activity

IC50
Antibacterial
5-10 µM

Target

L. donovani

Source & Reference

dbAMP DRAMP

Other

er-mondii (1.3 uM), C. tropicalis (11 uM) ( Mangoni ML et al. 2007 ). Parasite: inhibited L. donovani (IC50 5-10 uM) and L. pifanoi ()IC50 5-10 uM) ( Mangoni et al., 2006 . Cancer: It also showed anticancer
Evidence 3 Activity

Activity

MIC
Antifungal
8 µM

Target

Corynebacterium jeikeium ATCC BAA-949

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
ureus Cowan I (4.7 uM), S. lentus (2.0 uM), M. luteus (2.0 uM). Also active against Gram+ C. jeikeium ATCC BAA-949 (MIC 8 uM) ( Bruno Casciaro et al., 2020 ). fungi C. albicans ATCC 10231 (3.1 uM), C. guiller-mondii
Evidence 4 Activity

Activity

IC50
Antifungal
5-10 µM

Target

L. donovani

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

er-mondii (1.3 uM), C. tropicalis (11 uM) ( Mangoni ML et al. 2007 ). Parasite: inhibited L. donovani (IC50 5-10 uM) and L. pifanoi ()IC50 5-10 uM) ( Mangoni et al., 2006 . Cancer: It also showed anticancer
Evidence 5 Activity

Activity

MIC
Antiparasitic
8 µM

Target

Corynebacterium jeikeium ATCC BAA-949

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
ureus Cowan I (4.7 uM), S. lentus (2.0 uM), M. luteus (2.0 uM). Also active against Gram+ C. jeikeium ATCC BAA-949 (MIC 8 uM) ( Bruno Casciaro et al., 2020 ). fungi C. albicans ATCC 10231 (3.1 uM), C. guiller-mondii
Evidence 6 Activity

Activity

IC50
Antiparasitic
5-10 µM

Target

L. donovani

Source & Reference

DRAMP

Other

er-mondii (1.3 uM), C. tropicalis (11 uM) ( Mangoni ML et al. 2007 ). Parasite: inhibited L. donovani (IC50 5-10 uM) and L. pifanoi ()IC50 5-10 uM) ( Mangoni et al., 2006 . Cancer: It also showed anticancer
Evidence 7 Activity

Activity

MIC
Antiviral
8 µM

Target

Corynebacterium jeikeium ATCC BAA-949

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets.
ureus Cowan I (4.7 uM), S. lentus (2.0 uM), M. luteus (2.0 uM). Also active against Gram+ C. jeikeium ATCC BAA-949 (MIC 8 uM) ( Bruno Casciaro et al., 2020 ). fungi C. albicans ATCC 10231 (3.1 uM), C. guiller-mondii
Evidence 8 Activity

Activity

IC50
Antiviral
5-10 µM

Target

L. donovani

Source & Reference

DRAMP

Other

er-mondii (1.3 uM), C. tropicalis (11 uM) ( Mangoni ML et al. 2007 ). Parasite: inhibited L. donovani (IC50 5-10 uM) and L. pifanoi ()IC50 5-10 uM) ( Mangoni et al., 2006 . Cancer: It also showed anticancer
Evidence 9 Activity

Activity

Hemolysis
[Ref.8223491] Lethal concentration is 14.6 µM against human red blood cell.

Source & Reference

APD_complete APD_hemolytic
DRAMP4
EMBO J. 1993 12:4829-4832.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.
Evidence 10 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.8223491] Lethal concentration is 14.6 µM against human red blood cell.

Target

erythrocytes

Source & Reference

NA
DRAMP
EMBO J. 1993 12:4829-4832.
Evidence 11 Hemolysis

Activity

[Ref.8223491] Lethal concentration is 14.6 µM against human red blood cell.
Hemolysis

Source & Reference

APD_complete APD_hemolytic
EMBO J. 1993 12:4829-4832.
DRAMP4
APD_complete APD_hemolytic