TPDB09621

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1 µM

Target

Target Organism Escherichia coli ML-35

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

active against E. coli ML-35 (MIC 1 uM), P. aeruginosa ATCC 27853 or resistant strains (MIC 2-4 uM), S. typhimurium ATCC 14028 (M

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2-4 µM

Target

Target Organism Pseudomonas aeruginosa ATCC 27853 or resistant strains

Source & Reference

Database Source dbAMP

Other

Evidence Text

active against E. coli ML-35 (MIC 1 uM), P. aeruginosa ATCC 27853 or resistant strains (MIC 2-4 uM), S. typhimurium ATCC 14028 (MIC 4-8 ug/ml), S. aureus 710A or MRSA (MIC 2-8 uM), and B. m

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4-8 µg/mL

Target

Target Organism S. typhimurium ATCC 14028

Source & Reference

Database Source dbAMP

Other

Evidence Text

nst E. coli ML-35 (MIC 1 uM), P. aeruginosa ATCC 27853 or resistant strains (MIC 2-4 uM), S. typhimurium ATCC 14028 (MIC 4-8 ug/ml), S. aureus 710A or MRSA (MIC 2-8 uM), and B. megaterium BM11 (MIC 2 uM). Also active agai

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2-8 µM

Target

Target Organism Staphylococcus aureus 710A or MRSA

Source & Reference

Database Source dbAMP

Other

Evidence Text

ATCC 27853 or resistant strains (MIC 2-4 uM), S. typhimurium ATCC 14028 (MIC 4-8 ug/ml), S. aureus 710A or MRSA (MIC 2-8 uM), and B. megaterium BM11 (MIC 2 uM). Also active against drug-resistant strains S. simulan

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2 µM

Target

Target Organism B. megaterium BM11

Source & Reference

Database Source dbAMP

Other

Evidence Text

uM), S. typhimurium ATCC 14028 (MIC 4-8 ug/ml), S. aureus 710A or MRSA (MIC 2-8 uM), and B. megaterium BM11 (MIC 2 uM). Also active against drug-resistant strains S. simulans 22 (MIC 2 uM), M. luteus (MIC 1 u

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2 µM

Target

Target Organism Staphylococcus simulans 22

Source & Reference

Database Source dbAMP

Other

Evidence Text

IC 2-8 uM), and B. megaterium BM11 (MIC 2 uM). Also active against drug-resistant strains S. simulans 22 (MIC 2 uM), M. luteus (MIC 1 uM), Enterococcus spp (MIC 1-2 uM), S. haemolyticus I-10925 (MIC 1.5 uM

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1 µM

Target

Target Organism M. luteus

Source & Reference

Database Source dbAMP

Other

Evidence Text

um BM11 (MIC 2 uM). Also active against drug-resistant strains S. simulans 22 (MIC 2 uM), M. luteus (MIC 1 uM), Enterococcus spp (MIC 1-2 uM), S. haemolyticus I-10925 (MIC 1.5 uM), S. epidermidis (MIC

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.5 µM

Target

Target Organism Staphylococcus haemolyticus I-10925

Source & Reference

Database Source dbAMP

Other

Evidence Text

t strains S. simulans 22 (MIC 2 uM), M. luteus (MIC 1 uM), Enterococcus spp (MIC 1-2 uM), S. haemolyticus I-10925 (MIC 1.5 uM), S. epidermidis (MIC 1.5 uM), C. freundii I-11090 (MIC 2 uM), K. pneumoniae I-10910 (MIC

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.5 µM

Target

Target Organism Staphylococcus epidermidis

Source & Reference

Database Source dbAMP

Other

Evidence Text

. luteus (MIC 1 uM), Enterococcus spp (MIC 1-2 uM), S. haemolyticus I-10925 (MIC 1.5 uM), S. epidermidis (MIC 1.5 uM), C. freundii I-11090 (MIC 2 uM), K. pneumoniae I-10910 (MIC 1 uM), S. maltophila O-16451

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2 µM

Target

Target Organism Citrobacter freundii I-11090

Source & Reference

Database Source dbAMP

Other

Evidence Text

ccus spp (MIC 1-2 uM), S. haemolyticus I-10925 (MIC 1.5 uM), S. epidermidis (MIC 1.5 uM), C. freundii I-11090 (MIC 2 uM), K. pneumoniae I-10910 (MIC 1 uM), S. maltophila O-16451 or I-10717 (MIC 1-1.5 uM), and C

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1 µM

Target

Target Organism Klebsiella pneumoniae I-10910

Source & Reference

Database Source dbAMP

Other

Evidence Text

yticus I-10925 (MIC 1.5 uM), S. epidermidis (MIC 1.5 uM), C. freundii I-11090 (MIC 2 uM), K. pneumoniae I-10910 (MIC 1 uM), S. maltophila O-16451 or I-10717 (MIC 1-1.5 uM), and C. albicans (MIC 4 uM or greater),

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1-1.5 µM

Target

Target Organism S. maltophila O-16451 or I-10717

Source & Reference

Database Source dbAMP

Other

Evidence Text

idermidis (MIC 1.5 uM), C. freundii I-11090 (MIC 2 uM), K. pneumoniae I-10910 (MIC 1 uM), S. maltophila O-16451 or I-10717 (MIC 1-1.5 uM), and C. albicans (MIC 4 uM or greater),

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1 µM

Target

Target Organism Escherichia coli ML-35

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.

Evidence Text

active against E. coli ML-35 (MIC 1 uM), P. aeruginosa ATCC 27853 or resistant strains (MIC 2-4 uM), S. typhimurium ATCC 14028 (M

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2-4 µM

Target

Target Organism Pseudomonas aeruginosa ATCC 27853 or resistant strains

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

active against E. coli ML-35 (MIC 1 uM), P. aeruginosa ATCC 27853 or resistant strains (MIC 2-4 uM), S. typhimurium ATCC 14028 (MIC 4-8 ug/ml), S. aureus 710A or MRSA (MIC 2-8 uM), and B. m

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4-8 µg/mL

Target

Target Organism S. typhimurium ATCC 14028

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

nst E. coli ML-35 (MIC 1 uM), P. aeruginosa ATCC 27853 or resistant strains (MIC 2-4 uM), S. typhimurium ATCC 14028 (MIC 4-8 ug/ml), S. aureus 710A or MRSA (MIC 2-8 uM), and B. megaterium BM11 (MIC 2 uM). Also active agai

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2-8 µM

Target

Target Organism Staphylococcus aureus 710A or MRSA

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

ATCC 27853 or resistant strains (MIC 2-4 uM), S. typhimurium ATCC 14028 (MIC 4-8 ug/ml), S. aureus 710A or MRSA (MIC 2-8 uM), and B. megaterium BM11 (MIC 2 uM). Also active against drug-resistant strains S. simulan

Evidence 17 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2 µM

Target

Target Organism B. megaterium BM11

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

uM), S. typhimurium ATCC 14028 (MIC 4-8 ug/ml), S. aureus 710A or MRSA (MIC 2-8 uM), and B. megaterium BM11 (MIC 2 uM). Also active against drug-resistant strains S. simulans 22 (MIC 2 uM), M. luteus (MIC 1 u

Evidence 18 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2 µM

Target

Target Organism Staphylococcus simulans 22

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

IC 2-8 uM), and B. megaterium BM11 (MIC 2 uM). Also active against drug-resistant strains S. simulans 22 (MIC 2 uM), M. luteus (MIC 1 uM), Enterococcus spp (MIC 1-2 uM), S. haemolyticus I-10925 (MIC 1.5 uM

Evidence 19 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1 µM

Target

Target Organism M. luteus

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

um BM11 (MIC 2 uM). Also active against drug-resistant strains S. simulans 22 (MIC 2 uM), M. luteus (MIC 1 uM), Enterococcus spp (MIC 1-2 uM), S. haemolyticus I-10925 (MIC 1.5 uM), S. epidermidis (MIC

Evidence 20 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.5 µM

Target

Target Organism Staphylococcus haemolyticus I-10925

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

t strains S. simulans 22 (MIC 2 uM), M. luteus (MIC 1 uM), Enterococcus spp (MIC 1-2 uM), S. haemolyticus I-10925 (MIC 1.5 uM), S. epidermidis (MIC 1.5 uM), C. freundii I-11090 (MIC 2 uM), K. pneumoniae I-10910 (MIC

Evidence 21 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.5 µM

Target

Target Organism Staphylococcus epidermidis

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

. luteus (MIC 1 uM), Enterococcus spp (MIC 1-2 uM), S. haemolyticus I-10925 (MIC 1.5 uM), S. epidermidis (MIC 1.5 uM), C. freundii I-11090 (MIC 2 uM), K. pneumoniae I-10910 (MIC 1 uM), S. maltophila O-16451

Evidence 22 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2 µM

Target

Target Organism Citrobacter freundii I-11090

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

ccus spp (MIC 1-2 uM), S. haemolyticus I-10925 (MIC 1.5 uM), S. epidermidis (MIC 1.5 uM), C. freundii I-11090 (MIC 2 uM), K. pneumoniae I-10910 (MIC 1 uM), S. maltophila O-16451 or I-10717 (MIC 1-1.5 uM), and C

Evidence 23 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1 µM

Target

Target Organism Klebsiella pneumoniae I-10910

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

yticus I-10925 (MIC 1.5 uM), S. epidermidis (MIC 1.5 uM), C. freundii I-11090 (MIC 2 uM), K. pneumoniae I-10910 (MIC 1 uM), S. maltophila O-16451 or I-10717 (MIC 1-1.5 uM), and C. albicans (MIC 4 uM or greater),

Evidence 24 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1-1.5 µM

Target

Target Organism S. maltophila O-16451 or I-10717

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

idermidis (MIC 1.5 uM), C. freundii I-11090 (MIC 2 uM), K. pneumoniae I-10910 (MIC 1 uM), S. maltophila O-16451 or I-10717 (MIC 1-1.5 uM), and C. albicans (MIC 4 uM or greater),

Evidence 25 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 1 µM

Target

Target Organism Escherichia coli ML-35

Source & Reference

Database Source NA

Other

Evidence Text

active against E. coli ML-35 (MIC 1 uM), P. aeruginosa ATCC 27853 or resistant strains (MIC 2-4 uM), S. typhimurium ATCC 14028 (M

Evidence 26 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 2-4 µM

Target

Target Organism Pseudomonas aeruginosa ATCC 27853 or resistant strains

Source & Reference

Database Source NA

Other

Evidence Text

active against E. coli ML-35 (MIC 1 uM), P. aeruginosa ATCC 27853 or resistant strains (MIC 2-4 uM), S. typhimurium ATCC 14028 (MIC 4-8 ug/ml), S. aureus 710A or MRSA (MIC 2-8 uM), and B. m

Evidence 27 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 4-8 µg/mL

Target

Target Organism S. typhimurium ATCC 14028

Source & Reference

Database Source NA

Other

Evidence Text

nst E. coli ML-35 (MIC 1 uM), P. aeruginosa ATCC 27853 or resistant strains (MIC 2-4 uM), S. typhimurium ATCC 14028 (MIC 4-8 ug/ml), S. aureus 710A or MRSA (MIC 2-8 uM), and B. megaterium BM11 (MIC 2 uM). Also active agai

Evidence 28 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 2-8 µM

Target

Target Organism Staphylococcus aureus 710A or MRSA

Source & Reference

Database Source NA

Other

Evidence Text

ATCC 27853 or resistant strains (MIC 2-4 uM), S. typhimurium ATCC 14028 (MIC 4-8 ug/ml), S. aureus 710A or MRSA (MIC 2-8 uM), and B. megaterium BM11 (MIC 2 uM). Also active against drug-resistant strains S. simulan

Evidence 29 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 2 µM

Target

Target Organism B. megaterium BM11

Source & Reference

Database Source NA

Other

Evidence Text

uM), S. typhimurium ATCC 14028 (MIC 4-8 ug/ml), S. aureus 710A or MRSA (MIC 2-8 uM), and B. megaterium BM11 (MIC 2 uM). Also active against drug-resistant strains S. simulans 22 (MIC 2 uM), M. luteus (MIC 1 u

Evidence 30 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 2 µM

Target

Target Organism Staphylococcus simulans 22

Source & Reference

Database Source NA

Other

Evidence Text

IC 2-8 uM), and B. megaterium BM11 (MIC 2 uM). Also active against drug-resistant strains S. simulans 22 (MIC 2 uM), M. luteus (MIC 1 uM), Enterococcus spp (MIC 1-2 uM), S. haemolyticus I-10925 (MIC 1.5 uM

Evidence 31 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 1 µM

Target

Target Organism M. luteus

Source & Reference

Database Source NA

Other

Evidence Text

um BM11 (MIC 2 uM). Also active against drug-resistant strains S. simulans 22 (MIC 2 uM), M. luteus (MIC 1 uM), Enterococcus spp (MIC 1-2 uM), S. haemolyticus I-10925 (MIC 1.5 uM), S. epidermidis (MIC

Evidence 32 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 1.5 µM

Target

Target Organism Staphylococcus haemolyticus I-10925

Source & Reference

Database Source NA

Other

Evidence Text

t strains S. simulans 22 (MIC 2 uM), M. luteus (MIC 1 uM), Enterococcus spp (MIC 1-2 uM), S. haemolyticus I-10925 (MIC 1.5 uM), S. epidermidis (MIC 1.5 uM), C. freundii I-11090 (MIC 2 uM), K. pneumoniae I-10910 (MIC

Evidence 33 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 1.5 µM

Target

Target Organism Staphylococcus epidermidis

Source & Reference

Database Source NA

Other

Evidence Text

. luteus (MIC 1 uM), Enterococcus spp (MIC 1-2 uM), S. haemolyticus I-10925 (MIC 1.5 uM), S. epidermidis (MIC 1.5 uM), C. freundii I-11090 (MIC 2 uM), K. pneumoniae I-10910 (MIC 1 uM), S. maltophila O-16451

Evidence 34 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 2 µM

Target

Target Organism Citrobacter freundii I-11090

Source & Reference

Database Source NA

Other

Evidence Text

ccus spp (MIC 1-2 uM), S. haemolyticus I-10925 (MIC 1.5 uM), S. epidermidis (MIC 1.5 uM), C. freundii I-11090 (MIC 2 uM), K. pneumoniae I-10910 (MIC 1 uM), S. maltophila O-16451 or I-10717 (MIC 1-1.5 uM), and C

Evidence 35 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 1 µM

Target

Target Organism Klebsiella pneumoniae I-10910

Source & Reference

Database Source NA

Other

Evidence Text

yticus I-10925 (MIC 1.5 uM), S. epidermidis (MIC 1.5 uM), C. freundii I-11090 (MIC 2 uM), K. pneumoniae I-10910 (MIC 1 uM), S. maltophila O-16451 or I-10717 (MIC 1-1.5 uM), and C. albicans (MIC 4 uM or greater),

Evidence 36 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 1-1.5 µM

Target

Target Organism S. maltophila O-16451 or I-10717

Source & Reference

Database Source NA

Other

Evidence Text

idermidis (MIC 1.5 uM), C. freundii I-11090 (MIC 2 uM), K. pneumoniae I-10910 (MIC 1 uM), S. maltophila O-16451 or I-10717 (MIC 1-1.5 uM), and C. albicans (MIC 4 uM or greater),

Evidence 37 Activity

Activity

Activity Endpoint 15% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 10 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

15% Hemolysis | 10 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Identification and optimization of an antimicrobial peptide from the ant venom toxin pilosulin. | Arch Biochem Biophys | 2005

Evidence 38 Activity

Activity

Activity Endpoint 40% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 100 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

40% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Identification and optimization of an antimicrobial peptide from the ant venom toxin pilosulin. | Arch Biochem Biophys | 2005

Evidence 39 Hemolysis

Source & Reference

source HemoPI PD_Hemolysis

Database Source PD_Hemolysis