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Peptide record

TPDB09619

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard

20 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB09619

Activity

Antibacterial Anticancer Antifungal Antiparasitic Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AFP-GFuse Antifungipept CAFPdb ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 20-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

GLFTLIKCAYQLIAPTVACN

FASTA

>TPDB09619|Antibacterial;Anticancer;Antifungal;Antiparasitic;Toxicity|length=20
GLFTLIKCAYQLIAPTVACN

Formula C98H159N23O26S2

Absent Amino Acids RDEHMSW

Common Amino Acids AL

Mass 2139.60

PI 8.28

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 11

Net Charge +1

Boman Index -2.56

Hydrophobicity 1.110

Aliphatic Index 127.00

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 1615

Absorbance 280nm 75.48

Polar Residues 7

number

Amino Acid Distribution

A: 3 R: 0 N: 1 D: 0 C: 2 E: 0 Q: 1 G: 1 H: 0 I: 2 L: 3 K: 1 M: 0 F: 1 P: 1 S: 0 T: 2 W: 0 Y: 1 V: 1

Length

Formula

C98H159N23O26S2

Mass

2139.60

8.28

Net Charge

Boman Index

-2.56

Hydrophobicity

1.110

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 35.6 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

active against E. coli (MIC 35.6 ug/ml), S. aureus (MIC 17.8 ug/ml), B. subtilis (MIC 35.6 ug/ml), and C. albicans (MIC 8.9 ug/ml

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 17.8 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

active against E. coli (MIC 35.6 ug/ml), S. aureus (MIC 17.8 ug/ml), B. subtilis (MIC 35.6 ug/ml), and C. albicans (MIC 8.9 ug/ml). Aslo histamine release. U

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 35.6 µg/mL

Target

Target Organism B. subtilis

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

active against E. coli (MIC 35.6 ug/ml), S. aureus (MIC 17.8 ug/ml), B. subtilis (MIC 35.6 ug/ml), and C. albicans (MIC 8.9 ug/ml). Aslo histamine release. Updated 5/2020 7/2021

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8.9 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

t E. coli (MIC 35.6 ug/ml), S. aureus (MIC 17.8 ug/ml), B. subtilis (MIC 35.6 ug/ml), and C. albicans (MIC 8.9 ug/ml). Aslo histamine release. Updated 5/2020 7/2021

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 35.6 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

active against E. coli (MIC 35.6 ug/ml), S. aureus (MIC 17.8 ug/ml), B. subtilis (MIC 35.6 ug/ml), and C. albicans (MIC 8.9 ug/ml

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 17.8 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

active against E. coli (MIC 35.6 ug/ml), S. aureus (MIC 17.8 ug/ml), B. subtilis (MIC 35.6 ug/ml), and C. albicans (MIC 8.9 ug/ml). Aslo histamine release. U

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 35.6 µg/mL

Target

Target Organism B. subtilis

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

active against E. coli (MIC 35.6 ug/ml), S. aureus (MIC 17.8 ug/ml), B. subtilis (MIC 35.6 ug/ml), and C. albicans (MIC 8.9 ug/ml). Aslo histamine release. Updated 5/2020 7/2021

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 8.9 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

t E. coli (MIC 35.6 ug/ml), S. aureus (MIC 17.8 ug/ml), B. subtilis (MIC 35.6 ug/ml), and C. albicans (MIC 8.9 ug/ml). Aslo histamine release. Updated 5/2020 7/2021

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 35.6 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

active against E. coli (MIC 35.6 ug/ml), S. aureus (MIC 17.8 ug/ml), B. subtilis (MIC 35.6 ug/ml), and C. albicans (MIC 8.9 ug/ml

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 17.8 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source DRAMP

Other

Evidence Text

active against E. coli (MIC 35.6 ug/ml), S. aureus (MIC 17.8 ug/ml), B. subtilis (MIC 35.6 ug/ml), and C. albicans (MIC 8.9 ug/ml). Aslo histamine release. U

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 35.6 µg/mL

Target

Target Organism B. subtilis

Source & Reference

Database Source DRAMP

Other

Evidence Text

active against E. coli (MIC 35.6 ug/ml), S. aureus (MIC 17.8 ug/ml), B. subtilis (MIC 35.6 ug/ml), and C. albicans (MIC 8.9 ug/ml). Aslo histamine release. Updated 5/2020 7/2021

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 8.9 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source DRAMP

Other

Evidence Text

t E. coli (MIC 35.6 ug/ml), S. aureus (MIC 17.8 ug/ml), B. subtilis (MIC 35.6 ug/ml), and C. albicans (MIC 8.9 ug/ml). Aslo histamine release. Updated 5/2020 7/2021

Evidence 13 Activity

Activity

Activity Endpoint 0% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 50 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

0% Hemolysis | 50 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Anti-infection peptidomics of amphibian skin. | Mol Cell Proteomics | 2007

Evidence 14 Activity

Activity

Activity Endpoint (4.5±2.1)% degranulation

Detail Source Activity Toxicity

Activity Measurement 50 µg/mL

Toxicity Type Cytotoxic

Toxicity Raw

(4.5±2.1)% degranulation | 50 | µg/mL | target cell: Human mast cells

Target

Target Cell Human mast cells

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Anti-infection peptidomics of amphibian skin. | Mol Cell Proteomics | 2007