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Peptide record

TPDB09613

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB09613
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF AFP-GFuse Antifungipept CAFPdb ToxinPred 3.0
standard
No
A 20-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
AALKGCWTKSIPPKPCFGKR
Physicochemical Analysis
C100H162N28O23S2
NDEQHMYV
K
2188.68
10.55
5
0
6
+5
1.74
-0.420
49.00
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
5625
257.00
4
Residue Composition
number
2
A
1
R
0
N
0
D
2
C
0
E
0
Q
2
G
0
H
1
I
1
L
4
K
0
M
1
F
3
P
1
S
1
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 1 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 1 K: 4 M: 0 F: 1 P: 3 S: 1 T: 1 W: 1 Y: 0 V: 0
Chemical Descriptors
20
C100H162N28O23S2
2188.68
10.55
+5
1.74
-0.420
Evidence Records 15 records
Evidence 1 Activity

Activity

MIC
Antibacterial
3.2 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against active against E. coli (MIC 3.2 ug/ml), S. aureus (MIC 5.8 ug/ml), B. subtilis (MIC 1.85 ug/ml), and C. albicans (MIC 2.4 ug/ml)
Evidence 2 Activity

Activity

MIC
Antibacterial
5.8 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Active against active against E. coli (MIC 3.2 ug/ml), S. aureus (MIC 5.8 ug/ml), B. subtilis (MIC 1.85 ug/ml), and C. albicans (MIC 2.4 ug/ml). Aslo histamine release.
Evidence 3 Activity

Activity

MIC
Antibacterial
1.85 µg/mL

Target

B. subtilis

Source & Reference

dbAMP DRAMP

Other

Active against active against E. coli (MIC 3.2 ug/ml), S. aureus (MIC 5.8 ug/ml), B. subtilis (MIC 1.85 ug/ml), and C. albicans (MIC 2.4 ug/ml). Aslo histamine release.
Evidence 4 Activity

Activity

MIC
Antibacterial
2.4 µg/mL

Target

Candida albicans

Source & Reference

dbAMP DRAMP

Other

nst E. coli (MIC 3.2 ug/ml), S. aureus (MIC 5.8 ug/ml), B. subtilis (MIC 1.85 ug/ml), and C. albicans (MIC 2.4 ug/ml). Aslo histamine release.
Evidence 5 Activity

Activity

MIC
Antifungal
3.2 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against active against E. coli (MIC 3.2 ug/ml), S. aureus (MIC 5.8 ug/ml), B. subtilis (MIC 1.85 ug/ml), and C. albicans (MIC 2.4 ug/ml)
Evidence 6 Activity

Activity

MIC
Antifungal
5.8 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against active against E. coli (MIC 3.2 ug/ml), S. aureus (MIC 5.8 ug/ml), B. subtilis (MIC 1.85 ug/ml), and C. albicans (MIC 2.4 ug/ml). Aslo histamine release.
Evidence 7 Activity

Activity

MIC
Antifungal
1.85 µg/mL

Target

B. subtilis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against active against E. coli (MIC 3.2 ug/ml), S. aureus (MIC 5.8 ug/ml), B. subtilis (MIC 1.85 ug/ml), and C. albicans (MIC 2.4 ug/ml). Aslo histamine release.
Evidence 8 Activity

Activity

MIC
Antifungal
2.4 µg/mL

Target

Candida albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

nst E. coli (MIC 3.2 ug/ml), S. aureus (MIC 5.8 ug/ml), B. subtilis (MIC 1.85 ug/ml), and C. albicans (MIC 2.4 ug/ml). Aslo histamine release.
Evidence 9 Activity

Activity

MIC
Antiparasitic
3.2 µg/mL

Target

Escherichia coli

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against active against E. coli (MIC 3.2 ug/ml), S. aureus (MIC 5.8 ug/ml), B. subtilis (MIC 1.85 ug/ml), and C. albicans (MIC 2.4 ug/ml)
Evidence 10 Activity

Activity

MIC
Antiparasitic
5.8 µg/mL

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

Active against active against E. coli (MIC 3.2 ug/ml), S. aureus (MIC 5.8 ug/ml), B. subtilis (MIC 1.85 ug/ml), and C. albicans (MIC 2.4 ug/ml). Aslo histamine release.
Evidence 11 Activity

Activity

MIC
Antiparasitic
1.85 µg/mL

Target

B. subtilis

Source & Reference

DRAMP

Other

Active against active against E. coli (MIC 3.2 ug/ml), S. aureus (MIC 5.8 ug/ml), B. subtilis (MIC 1.85 ug/ml), and C. albicans (MIC 2.4 ug/ml). Aslo histamine release.
Evidence 12 Activity

Activity

MIC
Antiparasitic
2.4 µg/mL

Target

Candida albicans

Source & Reference

DRAMP

Other

nst E. coli (MIC 3.2 ug/ml), S. aureus (MIC 5.8 ug/ml), B. subtilis (MIC 1.85 ug/ml), and C. albicans (MIC 2.4 ug/ml). Aslo histamine release.
Evidence 13 Activity

Activity

0% Hemolysis
Toxicity
50 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 50 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Anti-infection peptidomics of amphibian skin. | Mol Cell Proteomics | 2007
Evidence 14 Activity

Activity

(2.6±1.3)% degranulation
Toxicity
50 µg/mL
Cytotoxic
(2.6±1.3)% degranulation | 50 | µg/mL | target cell: Human mast cells

Target

Human mast cells

Source & Reference

NA
DBAASP
Anti-infection peptidomics of amphibian skin. | Mol Cell Proteomics | 2007
Evidence 15 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref:17272268] No detectable hemolytic activity against rabbit red blood cells.

Target

erythrocytes

Source & Reference

NA
DRAMP
Mol Cell Proteomics. 2007 May 6(5):882-894.