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Peptide record

TPDB09611

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB09611
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP pep-lab Peptipedia Antifungipept CAFPdb ToxinPred 3.0
standard
No
A 20-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
QWGRRCCGWGPGRRYCRRWC
Physicochemical Analysis
C108H160N42O23S4
ANDEHILKMFSTV
R
2542.97
10.92
6
0
4
+6
-1.52
-1.385
0.00
Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour
18240
717.27
6
Residue Composition
number
0
A
6
R
0
N
0
D
4
C
0
E
1
Q
4
G
0
H
0
I
0
L
0
K
0
M
0
F
1
P
0
S
0
T
3
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 4 E: 0 Q: 1 G: 4 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 3 Y: 1 V: 0
Chemical Descriptors
20
C108H160N42O23S4
2542.97
10.92
+6
-1.52
-1.385
Evidence Records 14 records
Evidence 1 Activity

Activity

IC50
Antibacterial
3 µg/mL

Target

A. longipes

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against fungi A. longipes (IC50 3 ug/ml), B. cinerea (IC50 6 ug/m), C. sphaerospermum (IC50 1 ug/m), F. culmorum (IC50 1 ug/m), P.
Evidence 2 Activity

Activity

IC50
Antibacterial
1-3 µM

Target

F. culmorum

Source & Reference

dbAMP DRAMP

Other

as supplemented with 1 mM CaCl2 and 50 mM KCl. Also active against N. crassa, B. cinerea, F. culmorum (IC50 1-3 uM), S. cerevisiae (IC50 13 uM), and P. pastoris (IC50 5 uM). The N-terminal glutamine is bel
Evidence 3 Activity

Activity

IC50
Antibacterial
13 µM

Target

S. cerevisiae

Source & Reference

dbAMP DRAMP

Other

aCl2 and 50 mM KCl. Also active against N. crassa, B. cinerea, F. culmorum (IC50 1-3 uM), S. cerevisiae (IC50 13 uM), and P. pastoris (IC50 5 uM). The N-terminal glutamine is believed to be cyclized (i.e.,
Evidence 4 Activity

Activity

IC50
Antibacterial
5 µM

Target

P. pastoris

Source & Reference

dbAMP DRAMP

Other

against N. crassa, B. cinerea, F. culmorum (IC50 1-3 uM), S. cerevisiae (IC50 13 uM), and P. pastoris (IC50 5 uM). The N-terminal glutamine is believed to be cyclized (i.e., pyroglutamate, XXQ). It conta
Evidence 5 Activity

Activity

IC50
Antifungal
3 µg/mL

Target

A. longipes

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against fungi A. longipes (IC50 3 ug/ml), B. cinerea (IC50 6 ug/m), C. sphaerospermum (IC50 1 ug/m), F. culmorum (IC50 1 ug/m), P.
Evidence 6 Activity

Activity

IC50
Antifungal
1-3 µM

Target

F. culmorum

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

as supplemented with 1 mM CaCl2 and 50 mM KCl. Also active against N. crassa, B. cinerea, F. culmorum (IC50 1-3 uM), S. cerevisiae (IC50 13 uM), and P. pastoris (IC50 5 uM). The N-terminal glutamine is bel
Evidence 7 Activity

Activity

IC50
Antifungal
13 µM

Target

S. cerevisiae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

aCl2 and 50 mM KCl. Also active against N. crassa, B. cinerea, F. culmorum (IC50 1-3 uM), S. cerevisiae (IC50 13 uM), and P. pastoris (IC50 5 uM). The N-terminal glutamine is believed to be cyclized (i.e.,
Evidence 8 Activity

Activity

IC50
Antifungal
5 µM

Target

P. pastoris

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

against N. crassa, B. cinerea, F. culmorum (IC50 1-3 uM), S. cerevisiae (IC50 13 uM), and P. pastoris (IC50 5 uM). The N-terminal glutamine is believed to be cyclized (i.e., pyroglutamate, XXQ). It conta
Evidence 9 Activity

Activity

IC50
Antiparasitic
3 µg/mL

Target

A. longipes

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against fungi A. longipes (IC50 3 ug/ml), B. cinerea (IC50 6 ug/m), C. sphaerospermum (IC50 1 ug/m), F. culmorum (IC50 1 ug/m), P.
Evidence 10 Activity

Activity

IC50
Antiparasitic
1-3 µM

Target

F. culmorum

Source & Reference

DRAMP

Other

as supplemented with 1 mM CaCl2 and 50 mM KCl. Also active against N. crassa, B. cinerea, F. culmorum (IC50 1-3 uM), S. cerevisiae (IC50 13 uM), and P. pastoris (IC50 5 uM). The N-terminal glutamine is bel
Evidence 11 Activity

Activity

IC50
Antiparasitic
13 µM

Target

S. cerevisiae

Source & Reference

DRAMP

Other

aCl2 and 50 mM KCl. Also active against N. crassa, B. cinerea, F. culmorum (IC50 1-3 uM), S. cerevisiae (IC50 13 uM), and P. pastoris (IC50 5 uM). The N-terminal glutamine is believed to be cyclized (i.e.,
Evidence 12 Activity

Activity

IC50
Antiparasitic
5 µM

Target

P. pastoris

Source & Reference

DRAMP

Other

against N. crassa, B. cinerea, F. culmorum (IC50 1-3 uM), S. cerevisiae (IC50 13 uM), and P. pastoris (IC50 5 uM). The N-terminal glutamine is believed to be cyclized (i.e., pyroglutamate, XXQ). It conta
Evidence 13 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Bactericidal properties of the antimicrobial peptide Ib-AMP4 from Impatiens balsamina produced as a recombinant fusion-protein in Escherichia coli. | Biotechnol J | 2013
Evidence 14 Activity

Activity

15% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
15% Hemolysis | 200 | µg/mL | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Bactericidal properties of the antimicrobial peptide Ib-AMP4 from Impatiens balsamina produced as a recombinant fusion-protein in Escherichia coli. | Biotechnol J | 2013