TPDB

3D PDB MODEL

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TPDB ID TPDB09610

Activity

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb AI4AVP APD_complete PD_Hemolysis ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 20-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

ILGPVLSMVGSALGGLIKKI

FASTA

>TPDB09610|Antibacterial;Anticancer;Antifungal;Antiparasitic;Antiviral;Hemolysis;Toxicity|length=20
ILGPVLSMVGSALGGLIKKI

Formula C91H164N22O23S1

Absent Amino Acids RNDCEQHFTWY

Common Amino Acids GL

Mass 1966.50

PI 10.60

Basic Residues 2

Acidic Residues 0

Hydrophobic Residues 11

Net Charge +2

Boman Index -0.70

Hydrophobicity 1.410

Aliphatic Index 170.50

Half Life

Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 2

number

1

A

0

R

0

N

0

D

0

C

0

E

0

Q

4

G

0

H

3

I

4

L

2

K

1

M

0

F

1

P

2

S

0

T

0

W

0

Y

2

V

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 4 H: 0 I: 3 L: 4 K: 2 M: 1 F: 0 P: 1 S: 2 T: 0 W: 0 Y: 0 V: 2

Length

20

Formula

C91H164N22O23S1

Mass

1966.50

PI

10.60

Net Charge

+2

Boman Index

-0.70

Hydrophobicity

1.410

Evidence 1 Activity

Activity

Activity Endpoint % Hemolysis

Detail Source Activity Hemolysis

Activity Measurement 100 %

Hemolysis Raw

[Ref:11835991]90–100% hemolytic activity at 50 µg/ml against rabbit red blood cells

Target

RBC Target rabbit red blood cells

Source & Reference

Database Source Hemolytik APD_complete PD_Hemolysis

Source DRAMP4

Reference

Eur J Immunol. 2005 Apr 35(4):1220-9.##Peptides. 2002 Mar 23(3):427-435.

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.

Evidence 2 Activity

Activity

Activity Endpoint 100% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 50 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

100% Hemolysis | 50 | µg/mL | target cell: Rabbit erythrocytes

Target

Target Cell Rabbit erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Evidence 3 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic

Toxicity Raw

Hemolytic_activity: [Ref:11835991]90–100% hemolytic activity at 50 µg/ml against rabbit red blood cells

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Eur J Immunol. 2005 Apr 35(4):1220-9.##Peptides. 2002 Mar 23(3):427-435.

Evidence 4 Hemolysis

Activity

Activity Measurement 100 %

Activity Endpoint % Hemolysis

Hemolysis Raw

[Ref:11835991]90–100% hemolytic activity at 50 µg/ml against rabbit red blood cells

Detail Source Activity Hemolysis

Target

RBC Target rabbit red blood cells

Source & Reference

source APD_complete PD_Hemolysis

Reference

Eur J Immunol. 2005 Apr 35(4):1220-9.##Peptides. 2002 Mar 23(3):427-435.

Source DRAMP4

Database Source APD_complete PD_Hemolysis

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation.