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Peptide record

TPDB09606

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB09606
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 dbACP iACP-DRLF AFP-GFuse Antifungipept CAFPdb APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 20-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FLSLALAALPKLFCLIFKKC
Physicochemical Analysis
C110H179N23O22S2
RNDEQGHMTWYV
L
2239.89
9.80
3
0
13
+3
-4.50
1.600
151.50
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
125
5.58
3
Residue Composition
number
3
A
0
R
0
N
0
D
2
C
0
E
0
Q
0
G
0
H
1
I
6
L
3
K
0
M
3
F
1
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 0 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 6 K: 3 M: 0 F: 3 P: 1 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
20
C110H179N23O22S2
2239.89
9.80
+3
-4.50
1.600
Evidence Records 17 records
Evidence 1 Activity

Activity

MIC
Antibacterial
15-32 µM

Target

Staphylococcus aureus MRSA

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E. coli and S. aureus MRSA (MIC 15-32 uM) and hemolytic. It is also identified in another species in 2018 ( Zhang et al. BBRC2018 )
Evidence 2 Activity

Activity

MIC
Antibacterial
32 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP

Other

in 2018 ( Zhang et al. BBRC2018 ). Found in multiple species. Amurin-2 is active against C. albicans (MIC 32 uM) inactive E.coli (MIC >512 uM). It is hemolytic HC 50 4.7 uM. Helical in 50% TFE. Updated
Evidence 3 Activity

Activity

MIC
Antibacterial
>512 µM

Target

E.coli

Source & Reference

dbAMP DRAMP

Other

. Found in multiple species. Amurin-2 is active against C. albicans (MIC 32 uM) inactive E.coli (MIC >512 uM). It is hemolytic HC 50 4.7 uM. Helical in 50% TFE. Updated 12/2018 5/2020 7/2021
Evidence 4 Activity

Activity

MIC
Antifungal
15-32 µM

Target

Staphylococcus aureus MRSA

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against E. coli and S. aureus MRSA (MIC 15-32 uM) and hemolytic. It is also identified in another species in 2018 ( Zhang et al. BBRC2018 )
Evidence 5 Activity

Activity

MIC
Antifungal
32 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

in 2018 ( Zhang et al. BBRC2018 ). Found in multiple species. Amurin-2 is active against C. albicans (MIC 32 uM) inactive E.coli (MIC >512 uM). It is hemolytic HC 50 4.7 uM. Helical in 50% TFE. Updated
Evidence 6 Activity

Activity

MIC
Antifungal
>512 µM

Target

E.coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

. Found in multiple species. Amurin-2 is active against C. albicans (MIC 32 uM) inactive E.coli (MIC >512 uM). It is hemolytic HC 50 4.7 uM. Helical in 50% TFE. Updated 12/2018 5/2020 7/2021
Evidence 7 Activity

Activity

MIC
Antiparasitic
15-32 µM

Target

Staphylococcus aureus MRSA

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against E. coli and S. aureus MRSA (MIC 15-32 uM) and hemolytic. It is also identified in another species in 2018 ( Zhang et al. BBRC2018 )
Evidence 8 Activity

Activity

MIC
Antiparasitic
32 µM

Target

Candida albicans

Source & Reference

DRAMP

Other

in 2018 ( Zhang et al. BBRC2018 ). Found in multiple species. Amurin-2 is active against C. albicans (MIC 32 uM) inactive E.coli (MIC >512 uM). It is hemolytic HC 50 4.7 uM. Helical in 50% TFE. Updated
Evidence 9 Activity

Activity

MIC
Antiparasitic
>512 µM

Target

E.coli

Source & Reference

DRAMP

Other

. Found in multiple species. Amurin-2 is active against C. albicans (MIC 32 uM) inactive E.coli (MIC >512 uM). It is hemolytic HC 50 4.7 uM. Helical in 50% TFE. Updated 12/2018 5/2020 7/2021
Evidence 10 Activity

Activity

LC50
Hemolysis
6 µM
[Ref.17688900]LC50<6 µM against human erythrocytes

Target

human erythrocytes

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
Comp Biochem Physiol B Biochem Mol Biol. 2009 Oct 154(2):174-178.##Toxicon. 2007 Nov 50(6):746-756.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 11 Activity

Activity

50% Hemolysis
Toxicity
<5 µM
Hemolytic Cytotoxic
50% Hemolysis | <5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Cytolytic peptides belonging to the brevinin-1 and brevinin-2 families isolated from the skin of the Japanese brown frog, Rana dybowskii. | Toxicon | 2007
Evidence 12 Activity

Activity

50% Hemolysis
Toxicity
125 µM
Hemolytic Cytotoxic
50% Hemolysis | 125 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Characterization of antimicrobial peptides isolated from the skin of the Chinese frog, Rana dybowskii. | Comp Biochem Physiol B Biochem Mol Biol | 2009
Evidence 13 Activity

Activity

50% Hemolysis
Toxicity
7 µM
Hemolytic Cytotoxic
50% Hemolysis | 7 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A family of brevinin-2 peptides with potent activity against Pseudomonas aeruginosa from the skin of the Hokkaido frog, Rana pirica. | Regul Pept | 2004
Evidence 14 Activity

Activity

50% Hemolysis
Toxicity
4.7 µM
Hemolytic Cytotoxic
50% Hemolysis | 4.7 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Identification of novel Amurin-2 variants from the skin secretion of Rana amurensis, and the design of cationicity-enhanced analogues. | Biochem Biophys Res Commun | 2018
Evidence 15 Activity

Activity

IC50
Toxicity
25.2 µM
Cytotoxic
IC50 | 25.2 | µM | target cell: Human microvascular endothelial cells HMEC-1

Target

Human microvascular endothelial cells HMEC-1

Source & Reference

NA
DBAASP
Identification of novel Amurin-2 variants from the skin secretion of Rana amurensis, and the design of cationicity-enhanced analogues. | Biochem Biophys Res Commun | 2018
Evidence 16 Activity

Activity

LC50
Toxicity
6 µM
Hemolytic
Hemolytic_activity: [Ref.17688900]LC50<6 µM against human erythrocytes

Target

erythrocytes

Source & Reference

NA
DRAMP
Comp Biochem Physiol B Biochem Mol Biol. 2009 Oct 154(2):174-178.##Toxicon. 2007 Nov 50(6):746-756.
Evidence 17 Hemolysis

Activity

6 µM
LC50
[Ref.17688900]LC50<6 µM against human erythrocytes
Hemolysis

Target

human erythrocytes

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
Comp Biochem Physiol B Biochem Mol Biol. 2009 Oct 154(2):174-178.##Toxicon. 2007 Nov 50(6):746-756.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.