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Peptide record

TPDB09603

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB09603
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP pep-lab Peptipedia ACP740 _ACP240 AntiCP 2.0 SATPdb iACP-DRLF Antifungipept CAFPdb i2APP dbAMP 3.0 ToxinPred 3.0
standard
No
A 20-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FLGGLIKIVPAMICAVTKKC
Physicochemical Analysis
C97H169N23O22S3
RNDEQHSWY
IK
2105.73
9.80
3
0
11
+3
-0.51
1.400
136.50
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
125
5.94
3
Residue Composition
number
2
A
0
R
0
N
0
D
2
C
0
E
0
Q
2
G
0
H
3
I
2
L
3
K
1
M
1
F
1
P
0
S
1
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 2 H: 0 I: 3 L: 2 K: 3 M: 1 F: 1 P: 1 S: 0 T: 1 W: 0 Y: 0 V: 2
Chemical Descriptors
20
C97H169N23O22S3
2105.73
9.80
+3
-0.51
1.400
Evidence Records 15 records
Evidence 1 Activity

Activity

MIC
Antibacterial
4 µg/mL

Target

Staphylococcus aureus or MRSA

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
active as the WT against S. aureus or MRSA (MIC 4 ug/ml), P.aeruginosa (MIC 128 ug/ml), E. coli (MIC 32 ug/ml).
Evidence 2 Activity

Activity

MIC
Antibacterial
128 µg/mL

Target

P.aeruginosa

Source & Reference

dbAMP DRAMP

Other

active as the WT against S. aureus or MRSA (MIC 4 ug/ml), P.aeruginosa (MIC 128 ug/ml), E. coli (MIC 32 ug/ml).
Evidence 3 Activity

Activity

MIC
Antibacterial
32 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

active as the WT against S. aureus or MRSA (MIC 4 ug/ml), P.aeruginosa (MIC 128 ug/ml), E. coli (MIC 32 ug/ml).
Evidence 4 Activity

Activity

MIC
Antifungal
4 µg/mL

Target

Staphylococcus aureus or MRSA

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
active as the WT against S. aureus or MRSA (MIC 4 ug/ml), P.aeruginosa (MIC 128 ug/ml), E. coli (MIC 32 ug/ml).
Evidence 5 Activity

Activity

MIC
Antifungal
128 µg/mL

Target

P.aeruginosa

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

active as the WT against S. aureus or MRSA (MIC 4 ug/ml), P.aeruginosa (MIC 128 ug/ml), E. coli (MIC 32 ug/ml).
Evidence 6 Activity

Activity

MIC
Antifungal
32 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

active as the WT against S. aureus or MRSA (MIC 4 ug/ml), P.aeruginosa (MIC 128 ug/ml), E. coli (MIC 32 ug/ml).
Evidence 7 Activity

Activity

MIC
Antiparasitic
4 µg/mL

Target

Staphylococcus aureus or MRSA

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.
active as the WT against S. aureus or MRSA (MIC 4 ug/ml), P.aeruginosa (MIC 128 ug/ml), E. coli (MIC 32 ug/ml).
Evidence 8 Activity

Activity

MIC
Antiparasitic
128 µg/mL

Target

P.aeruginosa

Source & Reference

dbAMP 3.0 DRAMP

Other

active as the WT against S. aureus or MRSA (MIC 4 ug/ml), P.aeruginosa (MIC 128 ug/ml), E. coli (MIC 32 ug/ml).
Evidence 9 Activity

Activity

MIC
Antiparasitic
32 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP 3.0 DRAMP

Other

active as the WT against S. aureus or MRSA (MIC 4 ug/ml), P.aeruginosa (MIC 128 ug/ml), E. coli (MIC 32 ug/ml).
Evidence 10 Activity

Activity

MIC
Antiviral
4 µg/mL

Target

Staphylococcus aureus or MRSA

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets. dbAMP 3.0 classified under the Anti-viral function class.
active as the WT against S. aureus or MRSA (MIC 4 ug/ml), P.aeruginosa (MIC 128 ug/ml), E. coli (MIC 32 ug/ml).
Evidence 11 Activity

Activity

MIC
Antiviral
128 µg/mL

Target

P.aeruginosa

Source & Reference

dbAMP 3.0 DRAMP

Other

active as the WT against S. aureus or MRSA (MIC 4 ug/ml), P.aeruginosa (MIC 128 ug/ml), E. coli (MIC 32 ug/ml).
Evidence 12 Activity

Activity

MIC
Antiviral
32 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP 3.0 DRAMP

Other

active as the WT against S. aureus or MRSA (MIC 4 ug/ml), P.aeruginosa (MIC 128 ug/ml), E. coli (MIC 32 ug/ml).
Evidence 13 Activity

Activity

IC50
Toxicity
14.8 µg/mL
Cytotoxic
IC50 | 14.8 | µg/mL | target cell: Monkey COS-7 cells

Target

Monkey COS-7 cells

Source & Reference

NA
DBAASP
Molecular cloning and expression of ranalexin, a bioactive antimicrobial peptide from Rana catesbeiana in Escherichia coli and assessments of its biological activities. | Appl Microbiol Biotechnol | 2013
Evidence 14 Activity

Activity

<15% Hemolysis
Toxicity
250 µg/mL
Hemolytic Cytotoxic
<15% Hemolysis | 250 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial Activity of Novel Synthetic Peptides Derived from Indolicidin and Ranalexin against Streptococcus pneumoniae | PLoS One | 2015
Evidence 15 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Human lung normal epithelial cells NL20

Target

Human lung normal epithelial cells NL20

Source & Reference

NA
DBAASP
Antimicrobial Activity of Novel Synthetic Peptides Derived from Indolicidin and Ranalexin against Streptococcus pneumoniae | PLoS One | 2015