TPDB09599

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2.5-6 µM

Target

Target Organism Escherichia coli DH1

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against Gram- E. coli DH5alpha, E. coli DH1 (MIC 2.5-6 uM), P-aeruginosa (MIC>40 uM), Gram+ A. globiformis, B. subtilis (MIC 0.3-1.2 uM), yeasts P.

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.3-1.2 µM

Target

Target Organism B. subtilis

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

oli DH5alpha, E. coli DH1 (MIC 2.5-6 uM), P-aeruginosa (MIC>40 uM), Gram+ A. globiformis, B. subtilis (MIC 0.3-1.2 uM), yeasts P. pastoris, S. cerevisiae (MIC 20 uM). The same peptide called La47 is also foun

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 20 µM

Target

Target Organism S. cerevisiae

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

nosa (MIC>40 uM), Gram+ A. globiformis, B. subtilis (MIC 0.3-1.2 uM), yeasts P. pastoris, S. cerevisiae (MIC 20 uM). The same peptide called La47 is also found by Garcia F et al. (2013) J Antibiotic 66: 3-

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 100 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

013) J Antibiotic 66: 3-10. These authors found that the peptide is poorly active against E. coli (MIC 100 ug/ml) or S. aureus (MIC 84 ug/ml). Also Active against Gram- A. baumannii ATCC 003321216 (MIC 4

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 84 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

These authors found that the peptide is poorly active against E. coli (MIC 100 ug/ml) or S. aureus (MIC 84 ug/ml). Also Active against Gram- A. baumannii ATCC 003321216 (MIC 4 ug/ml), E.coli ATCC 25922 (

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µg/mL

Target

Target Organism A. baumannii ATCC 003321216

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

ve against E. coli (MIC 100 ug/ml) or S. aureus (MIC 84 ug/ml). Also Active against Gram- A. baumannii ATCC 003321216 (MIC 4 ug/ml), E.coli ATCC 25922 (MIC >128 ug/ml), K.pneumoniae ATCC 13883 (MIC >128 ug/ml), P.aerugino

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >128 µg/mL

Target

Target Organism E.coli ATCC 25922

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

reus (MIC 84 ug/ml). Also Active against Gram- A. baumannii ATCC 003321216 (MIC 4 ug/ml), E.coli ATCC 25922 (MIC >128 ug/ml), K.pneumoniae ATCC 13883 (MIC >128 ug/ml), P.aeruginosa KPC+ 003321199 (MIC >128 ug/ml),

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >128 µg/mL

Target

Target Organism K.pneumoniae ATCC 13883

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

inst Gram- A. baumannii ATCC 003321216 (MIC 4 ug/ml), E.coli ATCC 25922 (MIC >128 ug/ml), K.pneumoniae ATCC 13883 (MIC >128 ug/ml), P.aeruginosa KPC+ 003321199 (MIC >128 ug/ml), Gram+ P.acnes ATCC 51277 (MIC >128 ug/ml)

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >128 µg/mL

Target

Target Organism P.acnes ATCC 51277

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

eumoniae ATCC 13883 (MIC >128 ug/ml), P.aeruginosa KPC+ 003321199 (MIC >128 ug/ml), Gram+ P.acnes ATCC 51277 (MIC >128 ug/ml) and S.aureus ATCC 7133623 (MIC > 128 ug/ml). It also inhibits biofilm formation against A

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2.5-6 µM

Target

Target Organism Escherichia coli DH1

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against Gram- E. coli DH5alpha, E. coli DH1 (MIC 2.5-6 uM), P-aeruginosa (MIC>40 uM), Gram+ A. globiformis, B. subtilis (MIC 0.3-1.2 uM), yeasts P.

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 0.3-1.2 µM

Target

Target Organism B. subtilis

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

oli DH5alpha, E. coli DH1 (MIC 2.5-6 uM), P-aeruginosa (MIC>40 uM), Gram+ A. globiformis, B. subtilis (MIC 0.3-1.2 uM), yeasts P. pastoris, S. cerevisiae (MIC 20 uM). The same peptide called La47 is also foun

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 20 µM

Target

Target Organism S. cerevisiae

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

nosa (MIC>40 uM), Gram+ A. globiformis, B. subtilis (MIC 0.3-1.2 uM), yeasts P. pastoris, S. cerevisiae (MIC 20 uM). The same peptide called La47 is also found by Garcia F et al. (2013) J Antibiotic 66: 3-

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 100 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

013) J Antibiotic 66: 3-10. These authors found that the peptide is poorly active against E. coli (MIC 100 ug/ml) or S. aureus (MIC 84 ug/ml). Also Active against Gram- A. baumannii ATCC 003321216 (MIC 4

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 84 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

These authors found that the peptide is poorly active against E. coli (MIC 100 ug/ml) or S. aureus (MIC 84 ug/ml). Also Active against Gram- A. baumannii ATCC 003321216 (MIC 4 ug/ml), E.coli ATCC 25922 (

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4 µg/mL

Target

Target Organism A. baumannii ATCC 003321216

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

ve against E. coli (MIC 100 ug/ml) or S. aureus (MIC 84 ug/ml). Also Active against Gram- A. baumannii ATCC 003321216 (MIC 4 ug/ml), E.coli ATCC 25922 (MIC >128 ug/ml), K.pneumoniae ATCC 13883 (MIC >128 ug/ml), P.aerugino

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >128 µg/mL

Target

Target Organism E.coli ATCC 25922

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

reus (MIC 84 ug/ml). Also Active against Gram- A. baumannii ATCC 003321216 (MIC 4 ug/ml), E.coli ATCC 25922 (MIC >128 ug/ml), K.pneumoniae ATCC 13883 (MIC >128 ug/ml), P.aeruginosa KPC+ 003321199 (MIC >128 ug/ml),

Evidence 17 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >128 µg/mL

Target

Target Organism K.pneumoniae ATCC 13883

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

inst Gram- A. baumannii ATCC 003321216 (MIC 4 ug/ml), E.coli ATCC 25922 (MIC >128 ug/ml), K.pneumoniae ATCC 13883 (MIC >128 ug/ml), P.aeruginosa KPC+ 003321199 (MIC >128 ug/ml), Gram+ P.acnes ATCC 51277 (MIC >128 ug/ml)

Evidence 18 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >128 µg/mL

Target

Target Organism P.acnes ATCC 51277

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

eumoniae ATCC 13883 (MIC >128 ug/ml), P.aeruginosa KPC+ 003321199 (MIC >128 ug/ml), Gram+ P.acnes ATCC 51277 (MIC >128 ug/ml) and S.aureus ATCC 7133623 (MIC > 128 ug/ml). It also inhibits biofilm formation against A

Evidence 19 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 2.5-6 µM

Target

Target Organism Escherichia coli DH1

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.

Evidence Text

Active against Gram- E. coli DH5alpha, E. coli DH1 (MIC 2.5-6 uM), P-aeruginosa (MIC>40 uM), Gram+ A. globiformis, B. subtilis (MIC 0.3-1.2 uM), yeasts P.

Evidence 20 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 0.3-1.2 µM

Target

Target Organism B. subtilis

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

oli DH5alpha, E. coli DH1 (MIC 2.5-6 uM), P-aeruginosa (MIC>40 uM), Gram+ A. globiformis, B. subtilis (MIC 0.3-1.2 uM), yeasts P. pastoris, S. cerevisiae (MIC 20 uM). The same peptide called La47 is also foun

Evidence 21 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 20 µM

Target

Target Organism S. cerevisiae

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

nosa (MIC>40 uM), Gram+ A. globiformis, B. subtilis (MIC 0.3-1.2 uM), yeasts P. pastoris, S. cerevisiae (MIC 20 uM). The same peptide called La47 is also found by Garcia F et al. (2013) J Antibiotic 66: 3-

Evidence 22 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 100 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

013) J Antibiotic 66: 3-10. These authors found that the peptide is poorly active against E. coli (MIC 100 ug/ml) or S. aureus (MIC 84 ug/ml). Also Active against Gram- A. baumannii ATCC 003321216 (MIC 4

Evidence 23 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 84 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

These authors found that the peptide is poorly active against E. coli (MIC 100 ug/ml) or S. aureus (MIC 84 ug/ml). Also Active against Gram- A. baumannii ATCC 003321216 (MIC 4 ug/ml), E.coli ATCC 25922 (

Evidence 24 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 4 µg/mL

Target

Target Organism A. baumannii ATCC 003321216

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

ve against E. coli (MIC 100 ug/ml) or S. aureus (MIC 84 ug/ml). Also Active against Gram- A. baumannii ATCC 003321216 (MIC 4 ug/ml), E.coli ATCC 25922 (MIC >128 ug/ml), K.pneumoniae ATCC 13883 (MIC >128 ug/ml), P.aerugino

Evidence 25 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement >128 µg/mL

Target

Target Organism E.coli ATCC 25922

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

reus (MIC 84 ug/ml). Also Active against Gram- A. baumannii ATCC 003321216 (MIC 4 ug/ml), E.coli ATCC 25922 (MIC >128 ug/ml), K.pneumoniae ATCC 13883 (MIC >128 ug/ml), P.aeruginosa KPC+ 003321199 (MIC >128 ug/ml),

Evidence 26 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement >128 µg/mL

Target

Target Organism K.pneumoniae ATCC 13883

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

inst Gram- A. baumannii ATCC 003321216 (MIC 4 ug/ml), E.coli ATCC 25922 (MIC >128 ug/ml), K.pneumoniae ATCC 13883 (MIC >128 ug/ml), P.aeruginosa KPC+ 003321199 (MIC >128 ug/ml), Gram+ P.acnes ATCC 51277 (MIC >128 ug/ml)

Evidence 27 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement >128 µg/mL

Target

Target Organism P.acnes ATCC 51277

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

eumoniae ATCC 13883 (MIC >128 ug/ml), P.aeruginosa KPC+ 003321199 (MIC >128 ug/ml), Gram+ P.acnes ATCC 51277 (MIC >128 ug/ml) and S.aureus ATCC 7133623 (MIC > 128 ug/ml). It also inhibits biofilm formation against A

Evidence 28 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 2.5-6 µM

Target

Target Organism Escherichia coli DH1

Source & Reference

Database Source dbAMP 3.0 DRAMP DRAVP 2.0

Other

Source Activity Label	Source Definition
Antiviral	DRAMP antiviral activity supported by activity records against viral targets. dbAMP 3.0 classified under the Anti-viral function class.

Evidence Text

Active against Gram- E. coli DH5alpha, E. coli DH1 (MIC 2.5-6 uM), P-aeruginosa (MIC>40 uM), Gram+ A. globiformis, B. subtilis (MIC 0.3-1.2 uM), yeasts P.

Evidence 29 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 0.3-1.2 µM

Target

Target Organism B. subtilis

Source & Reference

Database Source dbAMP 3.0 DRAMP DRAVP 2.0

Other

Evidence Text

oli DH5alpha, E. coli DH1 (MIC 2.5-6 uM), P-aeruginosa (MIC>40 uM), Gram+ A. globiformis, B. subtilis (MIC 0.3-1.2 uM), yeasts P. pastoris, S. cerevisiae (MIC 20 uM). The same peptide called La47 is also foun

Evidence 30 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 20 µM

Target

Target Organism S. cerevisiae

Source & Reference

Database Source dbAMP 3.0 DRAMP DRAVP 2.0

Other

Evidence Text

nosa (MIC>40 uM), Gram+ A. globiformis, B. subtilis (MIC 0.3-1.2 uM), yeasts P. pastoris, S. cerevisiae (MIC 20 uM). The same peptide called La47 is also found by Garcia F et al. (2013) J Antibiotic 66: 3-

Evidence 31 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 100 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP 3.0 DRAMP DRAVP 2.0

Other

Evidence Text

013) J Antibiotic 66: 3-10. These authors found that the peptide is poorly active against E. coli (MIC 100 ug/ml) or S. aureus (MIC 84 ug/ml). Also Active against Gram- A. baumannii ATCC 003321216 (MIC 4

Evidence 32 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 84 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP 3.0 DRAMP DRAVP 2.0

Other

Evidence Text

These authors found that the peptide is poorly active against E. coli (MIC 100 ug/ml) or S. aureus (MIC 84 ug/ml). Also Active against Gram- A. baumannii ATCC 003321216 (MIC 4 ug/ml), E.coli ATCC 25922 (

Evidence 33 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 4 µg/mL

Target

Target Organism A. baumannii ATCC 003321216

Source & Reference

Database Source dbAMP 3.0 DRAMP DRAVP 2.0

Other

Evidence Text

ve against E. coli (MIC 100 ug/ml) or S. aureus (MIC 84 ug/ml). Also Active against Gram- A. baumannii ATCC 003321216 (MIC 4 ug/ml), E.coli ATCC 25922 (MIC >128 ug/ml), K.pneumoniae ATCC 13883 (MIC >128 ug/ml), P.aerugino

Evidence 34 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement >128 µg/mL

Target

Target Organism E.coli ATCC 25922

Source & Reference

Database Source dbAMP 3.0 DRAMP DRAVP 2.0

Other

Evidence Text

reus (MIC 84 ug/ml). Also Active against Gram- A. baumannii ATCC 003321216 (MIC 4 ug/ml), E.coli ATCC 25922 (MIC >128 ug/ml), K.pneumoniae ATCC 13883 (MIC >128 ug/ml), P.aeruginosa KPC+ 003321199 (MIC >128 ug/ml),

Evidence 35 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement >128 µg/mL

Target

Target Organism K.pneumoniae ATCC 13883

Source & Reference

Database Source dbAMP 3.0 DRAMP DRAVP 2.0

Other

Evidence Text

inst Gram- A. baumannii ATCC 003321216 (MIC 4 ug/ml), E.coli ATCC 25922 (MIC >128 ug/ml), K.pneumoniae ATCC 13883 (MIC >128 ug/ml), P.aeruginosa KPC+ 003321199 (MIC >128 ug/ml), Gram+ P.acnes ATCC 51277 (MIC >128 ug/ml)

Evidence 36 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement >128 µg/mL

Target

Target Organism P.acnes ATCC 51277

Source & Reference

Database Source dbAMP 3.0 DRAMP DRAVP 2.0

Other

Evidence Text

eumoniae ATCC 13883 (MIC >128 ug/ml), P.aeruginosa KPC+ 003321199 (MIC >128 ug/ml), Gram+ P.acnes ATCC 51277 (MIC >128 ug/ml) and S.aureus ATCC 7133623 (MIC > 128 ug/ml). It also inhibits biofilm formation against A

Evidence 37 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 128 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 128 | µg/mL | target cell: Mouse erythrocytes

Target

Target Cell Mouse erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

First generation of multifunctional peptides derived from latarcin-3a from Lachesana tarabaevi spider toxin. | Front Microbiol | 2022

Evidence 38 Activity

Activity

Activity Endpoint 20% Hemolysis

Detail Source Activity Toxicity

Activity Measurement >120 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

20% Hemolysis | >120 | µM | target cell: Rabbit erythrocytes

Target

Target Cell Rabbit erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Latarcins, antimicrobial and cytolytic peptides from the venom of the spider Lachesana tarabaevi (Zodariidae) that exemplify biomolecular diversity. | J Biol Chem | 2006

Evidence 39 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

- | NA | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Antimicrobial peptides from arachnid venoms and their microbicidal activity in the presence of commercial antibiotics. | J Antibiot (Tokyo) | 2013

Evidence 40 Activity

Activity

Activity Endpoint 50% Cell death

Detail Source Activity Toxicity

Activity Measurement >40.3 µM

Toxicity Type Cytotoxic

Toxicity Raw

50% Cell death | >40.3 | µM | target cell: CEM-SS cells

Target

Target Cell CEM-SS cells

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Identification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database. | Antimicrob Agents Chemother | 2010

Evidence 41 Activity

Activity

Activity Endpoint 16% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 256 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

16% Hemolysis | 256 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Membrane Interactions of Latarcins: Antimicrobial Peptides from Spider Venom | Int J Mol Sci | 2021

Evidence 42 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic

Toxicity Raw

Hemolytic_activity: [Ref.16735513]20% hemolytic activity at >120 µM against rabbit erythrocytes

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

J Biol Chem. 2006 Jul 28 281(30):20983-209892.

Evidence 43 Activity

Target

Target Organism Cutibacterium acnes

Source & Reference

Database Source DBAASP