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Peptide record

TPDB09598

Hepcidin Antibacterial Anticancer Antifungal Antiparasitic standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB09598
Hepcidin
Antibacterial Anticancer Antifungal Antiparasitic
Anti-infective peptides Cancer-related peptides
AntiBP3 dbAMP DRAMP pep-lab Peptipedia CancerPPD 2.0 dbACP Antifungipept CAFPdb
standard
No
A 20-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
ICIFCCGCCHRSKCGMCCKT
Physicochemical Analysis
C85H143N27O23S9
ANDEQLPWYV
C
2199.78
8.10
4
0
4
+3
0.14
0.795
39.00
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
500
22.73
10
Residue Composition
number
0
A
1
R
0
N
0
D
8
C
0
E
0
Q
2
G
1
H
2
I
0
L
2
K
1
M
1
F
0
P
1
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 8 E: 0 Q: 0 G: 2 H: 1 I: 2 L: 0 K: 2 M: 1 F: 1 P: 0 S: 1 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
20
C85H143N27O23S9
2199.78
8.10
+3
0.14
0.795
Free
L
Linear
Free
Antimicrobial and Anticancer
Homo sapiens
Evidence Records 7 records
Evidence 1 Activity

Activity

MIC
Antibacterial
5.38 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Activity against E. coli ML35p, P. aeruginosa, S. aureus (MIC 5.38ug/ml), S. epidermidis, group B Streptococcus, B. subtilis (MIC 2.69ug/ml), and fungus C. albica
Evidence 2 Activity

Activity

MIC
Antibacterial
2.69 µg/mL

Target

B. subtilis

Source & Reference

dbAMP DRAMP

Other

i ML35p, P. aeruginosa, S. aureus (MIC 5.38ug/ml), S. epidermidis, group B Streptococcus, B. subtilis (MIC 2.69ug/ml), and fungus C. albicans.
Evidence 3 Activity

Activity

Anticancer

Target

Lymphoma Cancer
U-266
Blood

Assay & Model

MTT assay

Source & Reference

CancerPPD 2.0 dbACP
CancerPPD2
2021

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 4 Activity

Activity

MIC
Antifungal
5.38 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Activity against E. coli ML35p, P. aeruginosa, S. aureus (MIC 5.38ug/ml), S. epidermidis, group B Streptococcus, B. subtilis (MIC 2.69ug/ml), and fungus C. albica
Evidence 5 Activity

Activity

MIC
Antifungal
2.69 µg/mL

Target

B. subtilis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

i ML35p, P. aeruginosa, S. aureus (MIC 5.38ug/ml), S. epidermidis, group B Streptococcus, B. subtilis (MIC 2.69ug/ml), and fungus C. albicans.
Evidence 6 Activity

Activity

MIC
Antiparasitic
5.38 µg/mL

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Activity against E. coli ML35p, P. aeruginosa, S. aureus (MIC 5.38ug/ml), S. epidermidis, group B Streptococcus, B. subtilis (MIC 2.69ug/ml), and fungus C. albica
Evidence 7 Activity

Activity

MIC
Antiparasitic
2.69 µg/mL

Target

B. subtilis

Source & Reference

DRAMP

Other

i ML35p, P. aeruginosa, S. aureus (MIC 5.38ug/ml), S. epidermidis, group B Streptococcus, B. subtilis (MIC 2.69ug/ml), and fungus C. albicans.