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Peptide record

TPDB09596

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB09596
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF Antifungipept APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 20-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FIGLLISAGKAIHDLIRRRH
Physicochemical Analysis
C104H176N34O24
NCEQMPTWYV
I
2286.75
12.12
6
1
10
+3
2.33
0.345
146.50
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
2
A
3
R
0
N
1
D
0
C
0
E
0
Q
2
G
2
H
4
I
3
L
1
K
0
M
1
F
0
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 3 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 2 H: 2 I: 4 L: 3 K: 1 M: 0 F: 1 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
20
C104H176N34O24
2286.75
12.12
+3
2.33
0.345
Evidence Records 17 records
Evidence 1 Activity

Activity

MIC
Antibacterial
10 µM

Target

S. iniae F-8502

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against Gram+ L. garvieae YT-3 (ATCC 49156) (MIC 10 uM), S. iniae F-8502 (MIC 10 uM), Gram- V. anguillarum ATCC 19264 (MIC 10 uM), Vibriopenaeicida KHA (MIC 10 uM), V. harvey
Evidence 2 Activity

Activity

MIC
Antibacterial
10 µM

Target

V. anguillarum ATCC 19264

Source & Reference

dbAMP DRAMP

Other

ainst Gram+ L. garvieae YT-3 (ATCC 49156) (MIC 10 uM), S. iniae F-8502 (MIC 10 uM), Gram- V. anguillarum ATCC 19264 (MIC 10 uM), Vibriopenaeicida KHA (MIC 10 uM), V. harveyi HUFP911 1 (ATCC 14126) (MIC 5 uM), V. vulni
Evidence 3 Activity

Activity

MIC
Antibacterial
10 µM

Target

A. salmonicida NCMB 1102

Source & Reference

dbAMP DRAMP

Other

(MIC 5 uM), V. vulnificus ET-7617(ATCC 33148) (MIC 10 uM), A-hydrophila ET-4 (MIC>40 uM), A. salmonicida NCMB 1102 (MIC 10 uM), P. putida ATCC 12633 (MIC 40 uM), and E-tarda ET-82016 (MIC>40 uM). Bactericidal activit
Evidence 4 Activity

Activity

MIC
Antibacterial
40 µM

Target

P. putida ATCC 12633

Source & Reference

dbAMP DRAMP

Other

33148) (MIC 10 uM), A-hydrophila ET-4 (MIC>40 uM), A. salmonicida NCMB 1102 (MIC 10 uM), P. putida ATCC 12633 (MIC 40 uM), and E-tarda ET-82016 (MIC>40 uM). Bactericidal activity (MLC): B. subtilis ATCC 6633 (ML
Evidence 5 Activity

Activity

MIC
Antifungal
10 µM

Target

S. iniae F-8502

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against Gram+ L. garvieae YT-3 (ATCC 49156) (MIC 10 uM), S. iniae F-8502 (MIC 10 uM), Gram- V. anguillarum ATCC 19264 (MIC 10 uM), Vibriopenaeicida KHA (MIC 10 uM), V. harvey
Evidence 6 Activity

Activity

MIC
Antifungal
10 µM

Target

V. anguillarum ATCC 19264

Source & Reference

dbAMP DRAMP Antifungipept

Other

ainst Gram+ L. garvieae YT-3 (ATCC 49156) (MIC 10 uM), S. iniae F-8502 (MIC 10 uM), Gram- V. anguillarum ATCC 19264 (MIC 10 uM), Vibriopenaeicida KHA (MIC 10 uM), V. harveyi HUFP911 1 (ATCC 14126) (MIC 5 uM), V. vulni
Evidence 7 Activity

Activity

MIC
Antifungal
10 µM

Target

A. salmonicida NCMB 1102

Source & Reference

dbAMP DRAMP Antifungipept

Other

(MIC 5 uM), V. vulnificus ET-7617(ATCC 33148) (MIC 10 uM), A-hydrophila ET-4 (MIC>40 uM), A. salmonicida NCMB 1102 (MIC 10 uM), P. putida ATCC 12633 (MIC 40 uM), and E-tarda ET-82016 (MIC>40 uM). Bactericidal activit
Evidence 8 Activity

Activity

MIC
Antifungal
40 µM

Target

P. putida ATCC 12633

Source & Reference

dbAMP DRAMP Antifungipept

Other

33148) (MIC 10 uM), A-hydrophila ET-4 (MIC>40 uM), A. salmonicida NCMB 1102 (MIC 10 uM), P. putida ATCC 12633 (MIC 40 uM), and E-tarda ET-82016 (MIC>40 uM). Bactericidal activity (MLC): B. subtilis ATCC 6633 (ML
Evidence 9 Activity

Activity

MIC
Antiparasitic
10 µM

Target

S. iniae F-8502

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against Gram+ L. garvieae YT-3 (ATCC 49156) (MIC 10 uM), S. iniae F-8502 (MIC 10 uM), Gram- V. anguillarum ATCC 19264 (MIC 10 uM), Vibriopenaeicida KHA (MIC 10 uM), V. harvey
Evidence 10 Activity

Activity

MIC
Antiparasitic
10 µM

Target

V. anguillarum ATCC 19264

Source & Reference

DRAMP

Other

ainst Gram+ L. garvieae YT-3 (ATCC 49156) (MIC 10 uM), S. iniae F-8502 (MIC 10 uM), Gram- V. anguillarum ATCC 19264 (MIC 10 uM), Vibriopenaeicida KHA (MIC 10 uM), V. harveyi HUFP911 1 (ATCC 14126) (MIC 5 uM), V. vulni
Evidence 11 Activity

Activity

MIC
Antiparasitic
10 µM

Target

A. salmonicida NCMB 1102

Source & Reference

DRAMP

Other

(MIC 5 uM), V. vulnificus ET-7617(ATCC 33148) (MIC 10 uM), A-hydrophila ET-4 (MIC>40 uM), A. salmonicida NCMB 1102 (MIC 10 uM), P. putida ATCC 12633 (MIC 40 uM), and E-tarda ET-82016 (MIC>40 uM). Bactericidal activit
Evidence 12 Activity

Activity

MIC
Antiparasitic
40 µM

Target

P. putida ATCC 12633

Source & Reference

DRAMP

Other

33148) (MIC 10 uM), A-hydrophila ET-4 (MIC>40 uM), A. salmonicida NCMB 1102 (MIC 10 uM), P. putida ATCC 12633 (MIC 40 uM), and E-tarda ET-82016 (MIC>40 uM). Bactericidal activity (MLC): B. subtilis ATCC 6633 (ML
Evidence 13 Activity

Activity

% Hemolysis
Hemolysis
0 10 %
[Ref.12581207]0% hemolytic activity at 0.25 µM, 10% hemolytic activity at 1 µM against human erythrocytes.

Target

human erythrocytes

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
Eur J Biochem. 2003 Feb 270(4):675-686.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 14 Activity

Activity

10% Hemolysis
Toxicity
1 µM
Hemolytic Cytotoxic
10% Hemolysis | 1 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Purification and characterization of three isoforms of chrysophsin, a novel antimicrobial peptide in the gills of the red sea bream, Chrysophrys major. | Eur J Biochem | 2003
Evidence 15 Activity

Activity

100% Hemolysis
Toxicity
10 µM
Hemolytic Cytotoxic
100% Hemolysis | 10 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Purification and characterization of three isoforms of chrysophsin, a novel antimicrobial peptide in the gills of the red sea bream, Chrysophrys major. | Eur J Biochem | 2003
Evidence 16 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.12581207]0% hemolytic activity at 0.25 µM, 10% hemolytic activity at 1 µM against human erythrocytes.

Target

erythrocytes

Source & Reference

NA
DRAMP
Eur J Biochem. 2003 Feb 270(4):675-686.
Evidence 17 Hemolysis

Activity

0 10 %
% Hemolysis
[Ref.12581207]0% hemolytic activity at 0.25 µM, 10% hemolytic activity at 1 µM against human erythrocytes.
Hemolysis

Target

human erythrocytes

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
Eur J Biochem. 2003 Feb 270(4):675-686.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.