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Peptide record

TPDB09593

Antibacterial Antifungal Antiviral Hemolysis Toxicity standard

20 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB09593

Activity

Antibacterial Antifungal Antiviral Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia Antifungipept AI4AVP dbAMP 3.0 DRAVP 2.0 APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 20-aa standard natural multi-activity (Antibacterial, Antifungal, Antiviral, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.

Sequence

FLPLILPSIVTALSSFLKQG

FASTA

>TPDB09593|Antibacterial;Antifungal;Antiviral;Hemolysis;Toxicity|length=20
FLPLILPSIVTALSSFLKQG

Formula C104H170N22O26

Absent Amino Acids RNDCEHMWY

Common Amino Acids L

Mass 2144.63

PI 10.10

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 11

Net Charge +1

Boman Index -2.77

Hydrophobicity 1.275

Aliphatic Index 156.00

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 5

number

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 0 I: 2 L: 5 K: 1 M: 0 F: 2 P: 2 S: 3 T: 1 W: 0 Y: 0 V: 1

Length

Formula

C104H170N22O26

Mass

2144.63

10.10

Net Charge

Boman Index

-2.77

Hydrophobicity

1.275

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 23.3 µM

Target

Target Organism B. cereus ATCC 14579

Source & Reference

Database Source NA

Other

Evidence Text

Active against Gram+ bacteria S. aureus ATCC 33591 (MRSA) (MIC 11.7 uM), B. cereus ATCC 14579 (MIC 23.3 uM), B. subtilis ATCC 23858 (MIC 23.3 uM), L. monocytogenes ATCC 7644 (MIC 46.6 uM). inactive

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 23.3 µM

Target

Target Organism B. subtilis ATCC 23858

Source & Reference

Database Source NA

Other

Evidence Text

+ bacteria S. aureus ATCC 33591 (MRSA) (MIC 11.7 uM), B. cereus ATCC 14579 (MIC 23.3 uM), B. subtilis ATCC 23858 (MIC 23.3 uM), L. monocytogenes ATCC 7644 (MIC 46.6 uM). inactive against Gram- C.freundii ATCC 8090, E

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 46.6 µM

Target

Target Organism L. monocytogenes ATCC 7644

Source & Reference

Database Source NA

Other

Evidence Text

(MIC 11.7 uM), B. cereus ATCC 14579 (MIC 23.3 uM), B. subtilis ATCC 23858 (MIC 23.3 uM), L. monocytogenes ATCC 7644 (MIC 46.6 uM). inactive against Gram- C.freundii ATCC 8090, E.sakazakii ATCC 29004, E.coli ATCC 29214,

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 23.3 µM

Target

Target Organism B. cereus ATCC 14579

Source & Reference

Database Source Antifungipept

Other

Evidence Text

Active against Gram+ bacteria S. aureus ATCC 33591 (MRSA) (MIC 11.7 uM), B. cereus ATCC 14579 (MIC 23.3 uM), B. subtilis ATCC 23858 (MIC 23.3 uM), L. monocytogenes ATCC 7644 (MIC 46.6 uM). inactive

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 23.3 µM

Target

Target Organism B. subtilis ATCC 23858

Source & Reference

Database Source Antifungipept

Other

Evidence Text

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 46.6 µM

Target

Target Organism L. monocytogenes ATCC 7644

Source & Reference

Database Source Antifungipept

Other

Evidence Text

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 23.3 µM

Target

Target Organism B. cereus ATCC 14579

Source & Reference

Database Source dbAMP 3.0 DRAVP 2.0

Other

Source Activity Label	Source Definition
Antiviral	dbAMP 3.0 classified under the Anti-viral function class.

Evidence Text

Active against Gram+ bacteria S. aureus ATCC 33591 (MRSA) (MIC 11.7 uM), B. cereus ATCC 14579 (MIC 23.3 uM), B. subtilis ATCC 23858 (MIC 23.3 uM), L. monocytogenes ATCC 7644 (MIC 46.6 uM). inactive

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 23.3 µM

Target

Target Organism B. subtilis ATCC 23858

Source & Reference

Database Source dbAMP 3.0 DRAVP 2.0

Other

Evidence Text

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 46.6 µM

Target

Target Organism L. monocytogenes ATCC 7644

Source & Reference

Database Source dbAMP 3.0 DRAVP 2.0

Other

Evidence Text

Evidence 10 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 82 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 82 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Identification and characterization of an antimicrobial peptide of Hypsiboas semilineatus (Spix, 1824) (Amphibia, Hylidae). | Toxicon | 2015

Evidence 11 Activity

Activity

Activity Endpoint 50% Cell death

Detail Source Activity Toxicity

Activity Measurement 31.25 µg/mL

Toxicity Type Cytotoxic

Toxicity Raw

50% Cell death | 31.25 | µg/mL | target cell: Vero cells

Target

Target Cell Vero cells

Source & Reference

Database Source NA

Source Database DBAASP

Reference

The Antimicrobial Peptide HS-1 Inhibits Dengue Virus Infection | Virology | 2018

Evidence 12 Hemolysis

Source & Reference

source APD_complete HemoPI PD_Hemolysis

Database Source APD_complete PD_Hemolysis

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation.