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Peptide record

TPDB09586

Antibacterial Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB09586
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP Peptipedia
standard
No
A 20-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, and Peptipedia, with an available 3D structural model.
Sequence
GSKKPVPIIYCNRRTKCQRM
Physicochemical Analysis
C101H176N34O26S3
ADEHLFW
RK
2378.90
10.88
6
0
5
+6
5.38
-0.925
53.50
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1615
67.89
7
Residue Composition
number
0
A
3
R
1
N
0
D
2
C
0
E
1
Q
1
G
0
H
2
I
0
L
3
K
1
M
0
F
2
P
1
S
1
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 3 N: 1 D: 0 C: 2 E: 0 Q: 1 G: 1 H: 0 I: 2 L: 0 K: 3 M: 1 F: 0 P: 2 S: 1 T: 1 W: 0 Y: 1 V: 1
Chemical Descriptors
20
C101H176N34O26S3
2378.90
10.88
+6
5.38
-0.925
Evidence Records 6 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2.6 µM

Target

Escherichia coli HB 101

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
active against E. coli HB 101 (MIC 2.6 uM), S. typhimurium (MIC 1.3 uM), P. aeruginosa (MIC 5.2 uM), B. subtilis (MIC 5.2 uM), and S
Evidence 2 Activity

Activity

MIC
Antibacterial
1.3 µM

Target

S. typhimurium

Source & Reference

dbAMP

Other

active against E. coli HB 101 (MIC 2.6 uM), S. typhimurium (MIC 1.3 uM), P. aeruginosa (MIC 5.2 uM), B. subtilis (MIC 5.2 uM), and S. aureus (MIC 20.8 uM).
Evidence 3 Activity

Activity

MIC
Antibacterial
5.2 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP

Other

active against E. coli HB 101 (MIC 2.6 uM), S. typhimurium (MIC 1.3 uM), P. aeruginosa (MIC 5.2 uM), B. subtilis (MIC 5.2 uM), and S. aureus (MIC 20.8 uM).
Evidence 4 Activity

Activity

MIC
Antibacterial
5.2 µM

Target

B. subtilis

Source & Reference

dbAMP

Other

nst E. coli HB 101 (MIC 2.6 uM), S. typhimurium (MIC 1.3 uM), P. aeruginosa (MIC 5.2 uM), B. subtilis (MIC 5.2 uM), and S. aureus (MIC 20.8 uM).
Evidence 5 Activity

Activity

MIC
Antibacterial
20.8 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP

Other

), S. typhimurium (MIC 1.3 uM), P. aeruginosa (MIC 5.2 uM), B. subtilis (MIC 5.2 uM), and S. aureus (MIC 20.8 uM).
Evidence 6 Activity

Activity

0% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 200 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Role of amino acid residues within the disulfide loop of thanatin, a potent antibiotic peptide. | J Biochem Mol Biol | 2002