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Peptide record

TPDB09585

Antibacterial Antifungal Toxicity standard

20 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB09585

Activity

Antibacterial Antifungal Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb

Sequence_Type

standard

Has_Modification No

Description A 20-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

GRFRRLRKKTRKRLKKIGKV

FASTA

>TPDB09585|Antibacterial;Antifungal;Toxicity|length=20
GRFRRLRKKTRKRLKKIGKV

Formula C112H210N44O22

Absent Amino Acids ANDCEQHMPSWY

Common Amino Acids RK

Mass 2525.18

PI 13.11

Basic Residues 12

Acidic Residues 0

Hydrophobic Residues 5

Net Charge +12

Boman Index 8.47

Hydrophobicity -1.640

Aliphatic Index 73.00

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

Amino Acid Distribution

A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 2 K: 6 M: 0 F: 1 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 1

Length

Formula

C112H210N44O22

Mass

2525.18

13.11

Net Charge

+12

Boman Index

8.47

Hydrophobicity

-1.640

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 32 µM

Target

Target Organism Escherichia coli 25922

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

active against E. coli 25922 (MIC 32 uM), E.coli 1005 (MIC 128 uM), S.typhimurium 7731 (MIC 128 uM), S.aureus 29213 (MIC 128 uM),

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 128 µM

Target

Target Organism E.coli 1005

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

active against E. coli 25922 (MIC 32 uM), E.coli 1005 (MIC 128 uM), S.typhimurium 7731 (MIC 128 uM), S.aureus 29213 (MIC 128 uM), S.epidermidis 12228 (MIC 1

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 128 µM

Target

Target Organism S.typhimurium 7731

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

active against E. coli 25922 (MIC 32 uM), E.coli 1005 (MIC 128 uM), S.typhimurium 7731 (MIC 128 uM), S.aureus 29213 (MIC 128 uM), S.epidermidis 12228 (MIC 128 uM), S.faecalis 29212 (MIC 128

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 128 µM

Target

Target Organism S.aureus 29213

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

nst E. coli 25922 (MIC 32 uM), E.coli 1005 (MIC 128 uM), S.typhimurium 7731 (MIC 128 uM), S.aureus 29213 (MIC 128 uM), S.epidermidis 12228 (MIC 128 uM), S.faecalis 29212 (MIC 128 uM).

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 128 µM

Target

Target Organism S.epidermidis 12228

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

, E.coli 1005 (MIC 128 uM), S.typhimurium 7731 (MIC 128 uM), S.aureus 29213 (MIC 128 uM), S.epidermidis 12228 (MIC 128 uM), S.faecalis 29212 (MIC 128 uM).

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 128 µM

Target

Target Organism S.faecalis 29212

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

imurium 7731 (MIC 128 uM), S.aureus 29213 (MIC 128 uM), S.epidermidis 12228 (MIC 128 uM), S.faecalis 29212 (MIC 128 uM).

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 32 µM

Target

Target Organism Escherichia coli 25922

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

active against E. coli 25922 (MIC 32 uM), E.coli 1005 (MIC 128 uM), S.typhimurium 7731 (MIC 128 uM), S.aureus 29213 (MIC 128 uM),

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 128 µM

Target

Target Organism E.coli 1005

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

active against E. coli 25922 (MIC 32 uM), E.coli 1005 (MIC 128 uM), S.typhimurium 7731 (MIC 128 uM), S.aureus 29213 (MIC 128 uM), S.epidermidis 12228 (MIC 1

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 128 µM

Target

Target Organism S.typhimurium 7731

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

active against E. coli 25922 (MIC 32 uM), E.coli 1005 (MIC 128 uM), S.typhimurium 7731 (MIC 128 uM), S.aureus 29213 (MIC 128 uM), S.epidermidis 12228 (MIC 128 uM), S.faecalis 29212 (MIC 128

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 128 µM

Target

Target Organism S.aureus 29213

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

nst E. coli 25922 (MIC 32 uM), E.coli 1005 (MIC 128 uM), S.typhimurium 7731 (MIC 128 uM), S.aureus 29213 (MIC 128 uM), S.epidermidis 12228 (MIC 128 uM), S.faecalis 29212 (MIC 128 uM).

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 128 µM

Target

Target Organism S.epidermidis 12228

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

, E.coli 1005 (MIC 128 uM), S.typhimurium 7731 (MIC 128 uM), S.aureus 29213 (MIC 128 uM), S.epidermidis 12228 (MIC 128 uM), S.faecalis 29212 (MIC 128 uM).

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 128 µM

Target

Target Organism S.faecalis 29212

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

imurium 7731 (MIC 128 uM), S.aureus 29213 (MIC 128 uM), S.epidermidis 12228 (MIC 128 uM), S.faecalis 29212 (MIC 128 uM).

Evidence 13 Activity

Activity

Activity Endpoint 5% Hemolysis

Detail Source Activity Toxicity

Activity Measurement >256 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

5% Hemolysis | >256 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Design of imperfectly amphipathic ?-helical antimicrobial peptides with enhanced cell selectivity. | Acta Biomater | 2014