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Peptide record

TPDB09582

Antibacterial Anticancer Antifungal Hemolysis Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB09582
Antibacterial Anticancer Antifungal Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF AFP-GFuse Antifungipept CAFPdb APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 20-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FLPLLLSALPSFLCLVFKKC
Physicochemical Analysis
C111H178N22O23S2
RNDEQGHIMTWY
L
2252.89
9.11
2
0
12
+2
-4.75
1.670
156.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
125
5.55
4
Residue Composition
number
1
A
0
R
0
N
0
D
2
C
0
E
0
Q
0
G
0
H
0
I
7
L
2
K
0
M
3
F
2
P
2
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 7 K: 2 M: 0 F: 3 P: 2 S: 2 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
20
C111H178N22O23S2
2252.89
9.11
+2
-4.75
1.670
Evidence Records 8 records
Evidence 1 Activity

Activity

MIC
Antibacterial
32 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against S. aureus (MIC 32 uM). Note that Amurin-2 is the same as AP602 in sequence. Amurin-2a is inactive (MIC >100 uM)
Evidence 2 Activity

Activity

MIC
Antibacterial
>100 µM

Target

e. Amurin-2a is inactive

Source & Reference

dbAMP DRAMP

Other

Active against S. aureus (MIC 32 uM). Note that Amurin-2 is the same as AP602 in sequence. Amurin-2a is inactive (MIC >100 uM), whilst Amurin-2c, another variant, is the same as AP601. Updated 5/2019
Evidence 3 Activity

Activity

MIC
Antifungal
32 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against S. aureus (MIC 32 uM). Note that Amurin-2 is the same as AP602 in sequence. Amurin-2a is inactive (MIC >100 uM)
Evidence 4 Activity

Activity

MIC
Antifungal
>100 µM

Target

e. Amurin-2a is inactive

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against S. aureus (MIC 32 uM). Note that Amurin-2 is the same as AP602 in sequence. Amurin-2a is inactive (MIC >100 uM), whilst Amurin-2c, another variant, is the same as AP601. Updated 5/2019
Evidence 5 Activity

Activity

50% Hemolysis
Toxicity
5 µM
Hemolytic Cytotoxic
50% Hemolysis | 5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Molecular cloning and functional characterization of novel antimicrobial peptides from the skin of brown frog, Rana zhenhaiensis. | Zoolog Sci | 2012
Evidence 6 Activity

Activity

50% Hemolysis
Toxicity
195.9 µM
Hemolytic Cytotoxic
50% Hemolysis | 195.9 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Identification of novel Amurin-2 variants from the skin secretion of Rana amurensis, and the design of cationicity-enhanced analogues. | Biochem Biophys Res Commun | 2018
Evidence 7 Activity

Activity

IC50
Toxicity
180.8 µM
Cytotoxic
IC50 | 180.8 | µM | target cell: Human microvascular endothelial cells HMEC-1

Target

Human microvascular endothelial cells HMEC-1

Source & Reference

NA
DBAASP
Identification of novel Amurin-2 variants from the skin secretion of Rana amurensis, and the design of cationicity-enhanced analogues. | Biochem Biophys Res Commun | 2018
Evidence 8 Hemolysis

Source & Reference

APD_complete HemoPI PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.