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Peptide record

TPDB09581

Lactoferrampin265-284 Antibacterial Anticancer Antifungal Antiparasitic Cell-penetrating Peptides standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB09581
Lactoferrampin265-284
Antibacterial Anticancer Antifungal Antiparasitic Cell-penetrating Peptides
Anti-infective peptides Cancer-related peptides Delivery and barrier-penetrating peptides
AntiBP3 Peptipedia CancerPPD 2.0 Antifungipept CAFPdb dbAMP CPPsite3.0
standard
No
A 20-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CancerPPD 2.0, and other sources, with an available 3D structural model.
Sequence
DLIWKLLSKAQEKFGKNKSR
Physicochemical Analysis
C109H181N31O29
CHMPTYV
K
2389.83
10.70
6
2
7
+4
5.14
-1.020
83.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
5500
230.14
4
Residue Composition
number
1
A
1
R
1
N
1
D
0
C
1
E
1
Q
1
G
0
H
1
I
3
L
5
K
0
M
1
F
0
P
2
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 1 D: 1 C: 0 E: 1 Q: 1 G: 1 H: 0 I: 1 L: 3 K: 5 M: 0 F: 1 P: 0 S: 2 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
20
C109H181N31O29
2389.83
10.70
+4
5.14
-1.020
Free
L
Cationic
Linear
Free
N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)O
Evidence Records 4 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against Gram- E. coli K12 (LC50 5.5 uM), and yeast C. albicans ATCC 10231 (LC50 0.7 uM). Warning: other bacteria not tested.
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against Gram- E. coli K12 (LC50 5.5 uM), and yeast C. albicans ATCC 10231 (LC50 0.7 uM). Warning: other bacteria not tested.
Evidence 3 Activity

Activity

Antiparasitic

Source & Reference

NA

Other

Active against Gram- E. coli K12 (LC50 5.5 uM), and yeast C. albicans ATCC 10231 (LC50 0.7 uM). Warning: other bacteria not tested.
Evidence 4 Activity

Activity

Cell-penetrating Peptides

Target

Enteroaggregative Escherichia Coli (Eaec)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
Cytoplasm
After 30 min of incubation LFcin17-30, LFampin265-284 and LFchimera can be found in the EAEC cytoplasm, and only a low proportion of the peptides were visualized on the membrane.
Membrane distruption
In vitro
CCCCSTTCSTTCCC
Additional Detail Fields 1 fields
CCCCSTTCSTTCCC