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Peptide record

TPDB09576

Antibacterial Anticancer Hemolysis Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB09576
Antibacterial Anticancer Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia PD_Hemolysis
standard
No
A 20-aa standard-residue multi-activity (Antibacterial, Anticancer, Hemolysis, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GILSKLGKALKKAAKHAAKA
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C91H166N28O22
RNDCEQMFPTWYV
AK
2004.49
11.21
7
0
10
+6
0.45
-0.075
108.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
6
A
0
R
0
N
0
D
0
C
0
E
0
Q
2
G
1
H
1
I
3
L
6
K
0
M
0
F
0
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 6 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 1 I: 1 L: 3 K: 6 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
20 reviewed residue count
C91H166N28O22 sequence-only estimate (linear, free termini)
2004.49 sequence-only estimate (linear, free termini)
11.21 sequence-only estimate (linear, free termini)
+6 sequence-only estimate (linear, free termini)
0.45 sequence-only estimate (linear, free termini)
-0.075 sequence-only estimate (linear, free termini)
Evidence Records 3 records
Evidence 1 Activity

Activity

30% Hemolysis
Toxicity
40 µM
Hemolytic Cytotoxic
30% Hemolysis | 40 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design of synthetic antimicrobial peptides based on sequence analogy and amphipathicity. | Eur J Biochem | 1997
Evidence 2 Activity

Activity

<=50% Cell death
Toxicity
40 µM
Cytotoxic
<=50% Cell death | 40 | µM | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
Design of synthetic antimicrobial peptides based on sequence analogy and amphipathicity. | Eur J Biochem | 1997
Evidence 3 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis