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Peptide record

TPDB09563

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB09563
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 20-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
LLSLALAALPKLFCLIFKKC
Physicochemical Analysis
C107H181N23O22S2
RNDEQGHMTWYV
L
2205.87
9.80
3
0
13
+3
-3.93
1.650
171.00
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
125
5.67
3
Residue Composition
number
3
A
0
R
0
N
0
D
2
C
0
E
0
Q
0
G
0
H
1
I
7
L
3
K
0
M
2
F
1
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 0 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 7 K: 3 M: 0 F: 2 P: 1 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
20
C107H181N23O22S2
2205.87
9.80
+3
-3.93
1.650
Evidence Records 12 records
Evidence 1 Activity

Activity

MIC
Antibacterial
25 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E. coli (MIC 25 uM) and S. aureus (MIC 12.5 uM).
Evidence 2 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Active against E. coli (MIC 25 uM) and S. aureus (MIC 12.5 uM).
Evidence 3 Activity

Activity

MIC
Antifungal
25 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against E. coli (MIC 25 uM) and S. aureus (MIC 12.5 uM).
Evidence 4 Activity

Activity

MIC
Antifungal
12.5 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP Antifungipept

Other

Active against E. coli (MIC 25 uM) and S. aureus (MIC 12.5 uM).
Evidence 5 Activity

Activity

MIC
Antiparasitic
25 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against E. coli (MIC 25 uM) and S. aureus (MIC 12.5 uM).
Evidence 6 Activity

Activity

MIC
Antiparasitic
12.5 µM

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

Active against E. coli (MIC 25 uM) and S. aureus (MIC 12.5 uM).
Evidence 7 Activity

Activity

MIC
Antiviral
25 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets.
Active against E. coli (MIC 25 uM) and S. aureus (MIC 12.5 uM).
Evidence 8 Activity

Activity

MIC
Antiviral
12.5 µM

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

Active against E. coli (MIC 25 uM) and S. aureus (MIC 12.5 uM).
Evidence 9 Activity

Activity

HC50
Hemolysis
125 µM
[Ref.19539775]HC50=125 µM against human red blood cells

Target

human red blood cells

Source & Reference

Hemolytik APD_complete PD_Hemolysis
DRAMP4
Comp Biochem Physiol B Biochem Mol Biol. 2009 Oct 154(2):174-178.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 10 Activity

Activity

50% Hemolysis
Toxicity
180±12 µM
Hemolytic Cytotoxic
50% Hemolysis | 180±12 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification and characterisation of a novel antimicrobial polypeptide from the skin secretion of a Chinese frog (Rana chensinensis). | Int J Antimicrob Agents | 2009
Evidence 11 Activity

Activity

HC50
Toxicity
125 µM
Hemolytic
Hemolytic_activity: [Ref.19539775]HC50=125 µM against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Comp Biochem Physiol B Biochem Mol Biol. 2009 Oct 154(2):174-178.
Evidence 12 Hemolysis

Activity

125 µM
HC50
[Ref.19539775]HC50=125 µM against human red blood cells
Hemolysis

Target

human red blood cells

Source & Reference

APD_complete HemoPI PD_Hemolysis
Comp Biochem Physiol B Biochem Mol Biol. 2009 Oct 154(2):174-178.
DRAMP4
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.