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Peptide record

TPDB09554

Anti-inflammatory Antibacterial Antifungal Hemolysis Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB09554
Anti-inflammatory Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Immunity and inflammation peptides Toxicity and safety peptides
Peptipedia AntiBP3 DRAMP Antifungipept APD_complete Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 20-aa standard natural multi-activity (Anti-inflammatory, Antibacterial, Antifungal, and other sources) peptide sequence curated from Peptipedia, AntiBP3, DRAMP, and other sources, with an available 3D structural model.
Sequence
KRFWQLVPLAIKIYRAWKRR
Physicochemical Analysis
C127H202N38O23
NDCEGHMST
R
2629.24
12.42
7
0
11
+7
-0.54
-0.535
102.50
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
12490
475.04
2
Residue Composition
number
2
A
4
R
0
N
0
D
0
C
0
E
1
Q
0
G
0
H
2
I
2
L
3
K
0
M
1
F
1
P
0
S
0
T
2
W
1
Y
1
V
Amino Acid Distribution
A: 2 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 2 L: 2 K: 3 M: 0 F: 1 P: 1 S: 0 T: 0 W: 2 Y: 1 V: 1
Chemical Descriptors
20
C127H202N38O23
2629.24
12.42
+7
-0.54
-0.535
Evidence Records 19 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2 µM

Target

Escherichia coli ATCC25922 or UB1005

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antibacterial
DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against Gram- bacteria E. coli ATCC25922 or UB1005 (MIC 2 uM), S. typhimurium ATCC14028 (MIC 4 uM), S. pullorum C79-13 (MIC 8 uM), Gram+ S. aureus ATCC
Evidence 2 Activity

Activity

MIC
Antibacterial
4 µM

Target

S. typhimurium ATCC14028

Source & Reference

DRAMP

Other

Active against Gram- bacteria E. coli ATCC25922 or UB1005 (MIC 2 uM), S. typhimurium ATCC14028 (MIC 4 uM), S. pullorum C79-13 (MIC 8 uM), Gram+ S. aureus ATCC29213 (MIC 4 uM), S. epidermidis ATCC
Evidence 3 Activity

Activity

MIC
Antibacterial
8 µM

Target

S. pullorum C79-13

Source & Reference

DRAMP

Other

am- bacteria E. coli ATCC25922 or UB1005 (MIC 2 uM), S. typhimurium ATCC14028 (MIC 4 uM), S. pullorum C79-13 (MIC 8 uM), Gram+ S. aureus ATCC29213 (MIC 4 uM), S. epidermidis ATCC12228 (MIC 4 uM), E. faecalis A
Evidence 4 Activity

Activity

MIC
Antibacterial
4 µM

Target

Staphylococcus aureus ATCC29213

Source & Reference

DRAMP

Other

005 (MIC 2 uM), S. typhimurium ATCC14028 (MIC 4 uM), S. pullorum C79-13 (MIC 8 uM), Gram+ S. aureus ATCC29213 (MIC 4 uM), S. epidermidis ATCC12228 (MIC 4 uM), E. faecalis ATCC29212 (MIC 4 uM), and B. subtilis C
Evidence 5 Activity

Activity

MIC
Antibacterial
4 µM

Target

Staphylococcus epidermidis ATCC12228

Source & Reference

DRAMP

Other

TCC14028 (MIC 4 uM), S. pullorum C79-13 (MIC 8 uM), Gram+ S. aureus ATCC29213 (MIC 4 uM), S. epidermidis ATCC12228 (MIC 4 uM), E. faecalis ATCC29212 (MIC 4 uM), and B. subtilis CMCC63501 (MIC 8 uM).
Evidence 6 Activity

Activity

MIC
Antibacterial
4 µM

Target

Enterococcus faecalis ATCC29212

Source & Reference

DRAMP

Other

13 (MIC 8 uM), Gram+ S. aureus ATCC29213 (MIC 4 uM), S. epidermidis ATCC12228 (MIC 4 uM), E. faecalis ATCC29212 (MIC 4 uM), and B. subtilis CMCC63501 (MIC 8 uM).
Evidence 7 Activity

Activity

MIC
Antibacterial
8 µM

Target

B. subtilis CMCC63501

Source & Reference

DRAMP

Other

13 (MIC 4 uM), S. epidermidis ATCC12228 (MIC 4 uM), E. faecalis ATCC29212 (MIC 4 uM), and B. subtilis CMCC63501 (MIC 8 uM).
Evidence 8 Activity

Activity

MIC
Antifungal
2 µM

Target

Escherichia coli ATCC25922 or UB1005

Source & Reference

DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against Gram- bacteria E. coli ATCC25922 or UB1005 (MIC 2 uM), S. typhimurium ATCC14028 (MIC 4 uM), S. pullorum C79-13 (MIC 8 uM), Gram+ S. aureus ATCC
Evidence 9 Activity

Activity

MIC
Antifungal
4 µM

Target

S. typhimurium ATCC14028

Source & Reference

DRAMP Antifungipept

Other

Active against Gram- bacteria E. coli ATCC25922 or UB1005 (MIC 2 uM), S. typhimurium ATCC14028 (MIC 4 uM), S. pullorum C79-13 (MIC 8 uM), Gram+ S. aureus ATCC29213 (MIC 4 uM), S. epidermidis ATCC
Evidence 10 Activity

Activity

MIC
Antifungal
8 µM

Target

S. pullorum C79-13

Source & Reference

DRAMP Antifungipept

Other

am- bacteria E. coli ATCC25922 or UB1005 (MIC 2 uM), S. typhimurium ATCC14028 (MIC 4 uM), S. pullorum C79-13 (MIC 8 uM), Gram+ S. aureus ATCC29213 (MIC 4 uM), S. epidermidis ATCC12228 (MIC 4 uM), E. faecalis A
Evidence 11 Activity

Activity

MIC
Antifungal
4 µM

Target

Staphylococcus aureus ATCC29213

Source & Reference

DRAMP Antifungipept

Other

005 (MIC 2 uM), S. typhimurium ATCC14028 (MIC 4 uM), S. pullorum C79-13 (MIC 8 uM), Gram+ S. aureus ATCC29213 (MIC 4 uM), S. epidermidis ATCC12228 (MIC 4 uM), E. faecalis ATCC29212 (MIC 4 uM), and B. subtilis C
Evidence 12 Activity

Activity

MIC
Antifungal
4 µM

Target

Staphylococcus epidermidis ATCC12228

Source & Reference

DRAMP Antifungipept

Other

TCC14028 (MIC 4 uM), S. pullorum C79-13 (MIC 8 uM), Gram+ S. aureus ATCC29213 (MIC 4 uM), S. epidermidis ATCC12228 (MIC 4 uM), E. faecalis ATCC29212 (MIC 4 uM), and B. subtilis CMCC63501 (MIC 8 uM).
Evidence 13 Activity

Activity

MIC
Antifungal
4 µM

Target

Enterococcus faecalis ATCC29212

Source & Reference

DRAMP Antifungipept

Other

13 (MIC 8 uM), Gram+ S. aureus ATCC29213 (MIC 4 uM), S. epidermidis ATCC12228 (MIC 4 uM), E. faecalis ATCC29212 (MIC 4 uM), and B. subtilis CMCC63501 (MIC 8 uM).
Evidence 14 Activity

Activity

MIC
Antifungal
8 µM

Target

B. subtilis CMCC63501

Source & Reference

DRAMP Antifungipept

Other

13 (MIC 4 uM), S. epidermidis ATCC12228 (MIC 4 uM), E. faecalis ATCC29212 (MIC 4 uM), and B. subtilis CMCC63501 (MIC 8 uM).
Evidence 15 Activity

Activity

50% Hemolysis
Toxicity
20 µM
Hemolytic Cytotoxic
50% Hemolysis | 20 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification of a novel cathelicidin antimicrobial peptide from ducks and determination of its functional activity and antibacterial mechanism. | Sci Rep | 2015
Evidence 16 Activity

Activity

50% Hemolysis
Toxicity
32 µM
Hemolytic Cytotoxic
50% Hemolysis | 32 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification of a novel cathelicidin antimicrobial peptide from ducks and determination of its functional activity and antibacterial mechanism. | Sci Rep | 2015
Evidence 17 Activity

Activity

50% Cell death
Toxicity
10 µM
Cytotoxic
50% Cell death | 10 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Identification of a novel cathelicidin antimicrobial peptide from ducks and determination of its functional activity and antibacterial mechanism. | Sci Rep | 2015
Evidence 18 Activity

Activity

% Hemolysis
Toxicity
10 %
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.32698035] HC10 = 5.1 µM. Note: HC10 is the peptide concentration that caused 10% hemolysis of sheep red blood cells (sRBCs). | Cytotoxicity: [Ref.32698035] At the concentration of 1.25, 2.5, 5, 10, 20, 40 and 80 µM, the cell survival of dCATH against human bone marrow SH-SY5Y cells is 103%, 103%, 100%, 68%, 36%, 13% and 8%.

Target

erythrocytes

Source & Reference

NA
DRAMP
Eur J Med Chem. 2020 Oct 15 204:112580. doi: 10.1016/j.ejmech.2020.112580. Epub 2020 Jul 16.
Evidence 19 Hemolysis

Source & Reference

APD_complete PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.