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Peptide record

TPDB09550

Antibacterial Antifungal Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB09550
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia CAFPdb dbAMP ToxinPred 3.0
standard
No
A 20-aa standard-residue multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.
Sequence
AVPLIYNRPGIYVTKRPKGK
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C106H176N30O25
DCEQHMFSW
KP
2270.75
10.95
5
0
8
+5
1.47
-0.505
92.50
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
2980
1.31
4
Residue Composition
number
1
A
2
R
1
N
0
D
0
C
0
E
0
Q
2
G
0
H
2
I
1
L
3
K
0
M
0
F
3
P
0
S
1
T
0
W
2
Y
2
V
Amino Acid Distribution
A: 1 R: 2 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 2 L: 1 K: 3 M: 0 F: 0 P: 3 S: 0 T: 1 W: 0 Y: 2 V: 2
Chemical Descriptors
20 reviewed residue count
C106H176N30O25 sequence-only estimate (linear, free termini)
2270.75 sequence-only estimate (linear, free termini)
10.95 sequence-only estimate (linear, free termini)
+5 sequence-only estimate (linear, free termini)
1.47 sequence-only estimate (linear, free termini)
-0.505 sequence-only estimate (linear, free termini)
Evidence Records 3 records
Evidence 1 Activity

Activity

0% Hemolysis
Toxicity
50 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 50 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Anti-infection peptidomics of amphibian skin. | Mol Cell Proteomics | 2007
Evidence 2 Activity

Activity

(17.7±5.5)% degranulation
Toxicity
50 µg/mL
Cytotoxic
(17.7±5.5)% degranulation | 50 | µg/mL | target cell: Human mast cells

Target

Human mast cells

Source & Reference

NA
DBAASP
Anti-infection peptidomics of amphibian skin. | Mol Cell Proteomics | 2007
Evidence 3 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref:17272268]Non-hemolytic activity against rabbit red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Mol Cell Proteomics. 2007 May 6(5):882-894.