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Peptide record

TPDB09545

Antibacterial Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB09545
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 20-aa standard-residue multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
KCRQWQSKIRRTNPIFCIRR
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C112H189N41O26S2
ADEGHLMYV
R
2590.11
12.24
7
0
5
+7
4.34
-1.175
58.50
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5625
2.17
7
Residue Composition
number
0
A
5
R
1
N
0
D
2
C
0
E
2
Q
0
G
0
H
3
I
0
L
2
K
0
M
1
F
1
P
1
S
1
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 5 N: 1 D: 0 C: 2 E: 0 Q: 2 G: 0 H: 0 I: 3 L: 0 K: 2 M: 0 F: 1 P: 1 S: 1 T: 1 W: 1 Y: 0 V: 0
Chemical Descriptors
20 reviewed residue count
C112H189N41O26S2 sequence-only estimate (linear, free termini)
2590.11 sequence-only estimate (linear, free termini)
12.24 sequence-only estimate (linear, free termini)
+7 sequence-only estimate (linear, free termini)
4.34 sequence-only estimate (linear, free termini)
-1.175 sequence-only estimate (linear, free termini)
Evidence Records 1 records
Evidence 1 Activity

Activity

3% Hemolysis
Toxicity
256 µg/mL
Hemolytic Cytotoxic
3% Hemolysis | 256 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Comparing bacterial membrane interactions and antimicrobial activity of porcine lactoferricin-derived peptides. | J Dairy Sci | 2013