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Peptide record

TPDB09539

Antibacterial Antifungal Hemolysis Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB09539
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP APD_complete PD_Hemolysis
standard
No
A 20-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
GNPLKLFLPSTWVHFFKFLR
Physicochemical Analysis
C123H179N29O24
ADCEQIMY
LF
2447.95
11.64
4
0
10
+3
-3.19
0.280
92.50
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
224.68
3
Residue Composition
number
0
A
1
R
1
N
0
D
0
C
0
E
0
Q
1
G
1
H
0
I
4
L
2
K
0
M
4
F
2
P
1
S
1
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 1 I: 0 L: 4 K: 2 M: 0 F: 4 P: 2 S: 1 T: 1 W: 1 Y: 0 V: 1
Chemical Descriptors
20
C123H179N29O24
2447.95
11.64
+3
-3.19
0.280
Evidence Records 18 records
Evidence 1 Activity

Activity

MIC
Antibacterial
4 µM

Target

Staphylococcus aureus ATCC 29213

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against Gram+ bacteria S. aureus ATCC 29213 (MIC 4 uM), L. monocytogenes ATCC 7611 (MIC 4 uM), L. casei HZ1 (MIC 32 uM) and Gram- E. aerogenes A
Evidence 2 Activity

Activity

MIC
Antibacterial
4 µM

Target

L. monocytogenes ATCC 7611

Source & Reference

dbAMP

Other

Active against Gram+ bacteria S. aureus ATCC 29213 (MIC 4 uM), L. monocytogenes ATCC 7611 (MIC 4 uM), L. casei HZ1 (MIC 32 uM) and Gram- E. aerogenes ATCC 13048 (MIC 64 uM). Inactive: K.pneu
Evidence 3 Activity

Activity

MIC
Antibacterial
32 µM

Target

L. casei HZ1

Source & Reference

dbAMP

Other

st Gram+ bacteria S. aureus ATCC 29213 (MIC 4 uM), L. monocytogenes ATCC 7611 (MIC 4 uM), L. casei HZ1 (MIC 32 uM) and Gram- E. aerogenes ATCC 13048 (MIC 64 uM). Inactive: K.pneumoniae ATCC 700603 (MIC>25
Evidence 4 Activity

Activity

MIC
Antibacterial
64 µM

Target

Enterobacter aerogenes ATCC 13048

Source & Reference

dbAMP

Other

213 (MIC 4 uM), L. monocytogenes ATCC 7611 (MIC 4 uM), L. casei HZ1 (MIC 32 uM) and Gram- E. aerogenes ATCC 13048 (MIC 64 uM). Inactive: K.pneumoniae ATCC 700603 (MIC>256 uM), fungi S.cerevisiae (MIC>256 uM) and P.p
Evidence 5 Activity

Activity

MIC
Antibacterial
>256 µM

Target

K.pneumoniae ATCC 700603

Source & Reference

dbAMP

Other

4 uM), L. casei HZ1 (MIC 32 uM) and Gram- E. aerogenes ATCC 13048 (MIC 64 uM). Inactive: K.pneumoniae ATCC 700603 (MIC>256 uM), fungi S.cerevisiae (MIC>256 uM) and P.pastoris (MIC>256 uM).
Evidence 6 Activity

Activity

MIC
Antibacterial
>256 µM

Target

S.cerevisiae

Source & Reference

dbAMP

Other

aerogenes ATCC 13048 (MIC 64 uM). Inactive: K.pneumoniae ATCC 700603 (MIC>256 uM), fungi S.cerevisiae (MIC>256 uM) and P.pastoris (MIC>256 uM).
Evidence 7 Activity

Activity

MIC
Antibacterial
>256 µM

Target

P.pastoris

Source & Reference

dbAMP

Other

uM). Inactive: K.pneumoniae ATCC 700603 (MIC>256 uM), fungi S.cerevisiae (MIC>256 uM) and P.pastoris (MIC>256 uM).
Evidence 8 Activity

Activity

MIC
Antifungal
4 µM

Target

Staphylococcus aureus ATCC 29213

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against Gram+ bacteria S. aureus ATCC 29213 (MIC 4 uM), L. monocytogenes ATCC 7611 (MIC 4 uM), L. casei HZ1 (MIC 32 uM) and Gram- E. aerogenes A
Evidence 9 Activity

Activity

MIC
Antifungal
4 µM

Target

L. monocytogenes ATCC 7611

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against Gram+ bacteria S. aureus ATCC 29213 (MIC 4 uM), L. monocytogenes ATCC 7611 (MIC 4 uM), L. casei HZ1 (MIC 32 uM) and Gram- E. aerogenes ATCC 13048 (MIC 64 uM). Inactive: K.pneu
Evidence 10 Activity

Activity

MIC
Antifungal
32 µM

Target

L. casei HZ1

Source & Reference

dbAMP CAFPdb Antifungipept

Other

st Gram+ bacteria S. aureus ATCC 29213 (MIC 4 uM), L. monocytogenes ATCC 7611 (MIC 4 uM), L. casei HZ1 (MIC 32 uM) and Gram- E. aerogenes ATCC 13048 (MIC 64 uM). Inactive: K.pneumoniae ATCC 700603 (MIC>25
Evidence 11 Activity

Activity

MIC
Antifungal
64 µM

Target

Enterobacter aerogenes ATCC 13048

Source & Reference

dbAMP CAFPdb Antifungipept

Other

213 (MIC 4 uM), L. monocytogenes ATCC 7611 (MIC 4 uM), L. casei HZ1 (MIC 32 uM) and Gram- E. aerogenes ATCC 13048 (MIC 64 uM). Inactive: K.pneumoniae ATCC 700603 (MIC>256 uM), fungi S.cerevisiae (MIC>256 uM) and P.p
Evidence 12 Activity

Activity

MIC
Antifungal
>256 µM

Target

K.pneumoniae ATCC 700603

Source & Reference

dbAMP CAFPdb Antifungipept

Other

4 uM), L. casei HZ1 (MIC 32 uM) and Gram- E. aerogenes ATCC 13048 (MIC 64 uM). Inactive: K.pneumoniae ATCC 700603 (MIC>256 uM), fungi S.cerevisiae (MIC>256 uM) and P.pastoris (MIC>256 uM).
Evidence 13 Activity

Activity

MIC
Antifungal
>256 µM

Target

S.cerevisiae

Source & Reference

dbAMP CAFPdb Antifungipept

Other

aerogenes ATCC 13048 (MIC 64 uM). Inactive: K.pneumoniae ATCC 700603 (MIC>256 uM), fungi S.cerevisiae (MIC>256 uM) and P.pastoris (MIC>256 uM).
Evidence 14 Activity

Activity

MIC
Antifungal
>256 µM

Target

P.pastoris

Source & Reference

dbAMP CAFPdb Antifungipept

Other

uM). Inactive: K.pneumoniae ATCC 700603 (MIC>256 uM), fungi S.cerevisiae (MIC>256 uM) and P.pastoris (MIC>256 uM).
Evidence 15 Activity

Activity

<10% Hemolysis
Toxicity
8 µM
Hemolytic Cytotoxic
<10% Hemolysis | 8 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Identification, Recombinant Expression, and Characterization of LHG2, a Novel Antimicrobial Peptide of Lactobacillus casei HZ1. | Molecules | 2018
Evidence 16 Activity

Activity

<20% Hemolysis
Toxicity
16 µM
Hemolytic Cytotoxic
<20% Hemolysis | 16 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Identification, Recombinant Expression, and Characterization of LHG2, a Novel Antimicrobial Peptide of Lactobacillus casei HZ1. | Molecules | 2018
Evidence 17 Activity

Activity

50% Hemolysis
Toxicity
40 µM
Hemolytic Cytotoxic
50% Hemolysis | 40 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Identification, Recombinant Expression, and Characterization of LHG2, a Novel Antimicrobial Peptide of Lactobacillus casei HZ1. | Molecules | 2018
Evidence 18 Hemolysis

Source & Reference

APD_complete PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.