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Peptide record

TPDB09539

Antibacterial Antifungal Hemolysis Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB09539
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP APD_complete PD_Hemolysis
standard
No
A 20-aa standard-residue multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
GNPLKLFLPSTWVHFFKFLR
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C123H179N29O24
ADCEQIMY
LF
2447.95
11.64
4
0
10
+3
0.22
0.280
92.50
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
2.25
3
Residue Composition
number
0
A
1
R
1
N
0
D
0
C
0
E
0
Q
1
G
1
H
0
I
4
L
2
K
0
M
4
F
2
P
1
S
1
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 1 I: 0 L: 4 K: 2 M: 0 F: 4 P: 2 S: 1 T: 1 W: 1 Y: 0 V: 1
Chemical Descriptors
20 reviewed residue count
C123H179N29O24 sequence-only estimate (linear, free termini)
2447.95 sequence-only estimate (linear, free termini)
11.64 sequence-only estimate (linear, free termini)
+3 sequence-only estimate (linear, free termini)
0.22 sequence-only estimate (linear, free termini)
0.280 sequence-only estimate (linear, free termini)
Evidence Records 18 records
Evidence 1 Activity

Activity

MIC
Antibacterial
4 µM

Target

Staphylococcus aureus ATCC 29213

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against Gram+ bacteria S. aureus ATCC 29213 (MIC 4 uM), L. monocytogenes ATCC 7611 (MIC 4 uM), L. casei HZ1 (MIC 32 uM) and Gram- E. aerogenes A
Evidence 2 Activity

Activity

MIC
Antibacterial
4 µM

Target

L. monocytogenes ATCC 7611

Source & Reference

dbAMP

Other

Active against Gram+ bacteria S. aureus ATCC 29213 (MIC 4 uM), L. monocytogenes ATCC 7611 (MIC 4 uM), L. casei HZ1 (MIC 32 uM) and Gram- E. aerogenes ATCC 13048 (MIC 64 uM). Inactive: K.pneu
Evidence 3 Activity

Activity

MIC
Antibacterial
32 µM

Target

L. casei HZ1

Source & Reference

dbAMP

Other

st Gram+ bacteria S. aureus ATCC 29213 (MIC 4 uM), L. monocytogenes ATCC 7611 (MIC 4 uM), L. casei HZ1 (MIC 32 uM) and Gram- E. aerogenes ATCC 13048 (MIC 64 uM). Inactive: K.pneumoniae ATCC 700603 (MIC>25
Evidence 4 Activity

Activity

MIC
Antibacterial
64 µM

Target

Enterobacter aerogenes ATCC 13048

Source & Reference

dbAMP

Other

213 (MIC 4 uM), L. monocytogenes ATCC 7611 (MIC 4 uM), L. casei HZ1 (MIC 32 uM) and Gram- E. aerogenes ATCC 13048 (MIC 64 uM). Inactive: K.pneumoniae ATCC 700603 (MIC>256 uM), fungi S.cerevisiae (MIC>256 uM) and P.p
Evidence 5 Activity

Activity

MIC
Antibacterial
>256 µM

Target

K.pneumoniae ATCC 700603

Source & Reference

dbAMP

Other

4 uM), L. casei HZ1 (MIC 32 uM) and Gram- E. aerogenes ATCC 13048 (MIC 64 uM). Inactive: K.pneumoniae ATCC 700603 (MIC>256 uM), fungi S.cerevisiae (MIC>256 uM) and P.pastoris (MIC>256 uM).
Evidence 6 Activity

Activity

MIC
Antibacterial
>256 µM

Target

S.cerevisiae

Source & Reference

dbAMP

Other

aerogenes ATCC 13048 (MIC 64 uM). Inactive: K.pneumoniae ATCC 700603 (MIC>256 uM), fungi S.cerevisiae (MIC>256 uM) and P.pastoris (MIC>256 uM).
Evidence 7 Activity

Activity

MIC
Antibacterial
>256 µM

Target

P.pastoris

Source & Reference

dbAMP

Other

uM). Inactive: K.pneumoniae ATCC 700603 (MIC>256 uM), fungi S.cerevisiae (MIC>256 uM) and P.pastoris (MIC>256 uM).
Evidence 8 Activity

Activity

MIC
Antifungal
4 µM

Target

Staphylococcus aureus ATCC 29213

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against Gram+ bacteria S. aureus ATCC 29213 (MIC 4 uM), L. monocytogenes ATCC 7611 (MIC 4 uM), L. casei HZ1 (MIC 32 uM) and Gram- E. aerogenes A
Evidence 9 Activity

Activity

MIC
Antifungal
4 µM

Target

L. monocytogenes ATCC 7611

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against Gram+ bacteria S. aureus ATCC 29213 (MIC 4 uM), L. monocytogenes ATCC 7611 (MIC 4 uM), L. casei HZ1 (MIC 32 uM) and Gram- E. aerogenes ATCC 13048 (MIC 64 uM). Inactive: K.pneu
Evidence 10 Activity

Activity

MIC
Antifungal
32 µM

Target

L. casei HZ1

Source & Reference

dbAMP CAFPdb Antifungipept

Other

st Gram+ bacteria S. aureus ATCC 29213 (MIC 4 uM), L. monocytogenes ATCC 7611 (MIC 4 uM), L. casei HZ1 (MIC 32 uM) and Gram- E. aerogenes ATCC 13048 (MIC 64 uM). Inactive: K.pneumoniae ATCC 700603 (MIC>25
Evidence 11 Activity

Activity

MIC
Antifungal
64 µM

Target

Enterobacter aerogenes ATCC 13048

Source & Reference

dbAMP CAFPdb Antifungipept

Other

213 (MIC 4 uM), L. monocytogenes ATCC 7611 (MIC 4 uM), L. casei HZ1 (MIC 32 uM) and Gram- E. aerogenes ATCC 13048 (MIC 64 uM). Inactive: K.pneumoniae ATCC 700603 (MIC>256 uM), fungi S.cerevisiae (MIC>256 uM) and P.p
Evidence 12 Activity

Activity

MIC
Antifungal
>256 µM

Target

K.pneumoniae ATCC 700603

Source & Reference

dbAMP CAFPdb Antifungipept

Other

4 uM), L. casei HZ1 (MIC 32 uM) and Gram- E. aerogenes ATCC 13048 (MIC 64 uM). Inactive: K.pneumoniae ATCC 700603 (MIC>256 uM), fungi S.cerevisiae (MIC>256 uM) and P.pastoris (MIC>256 uM).
Evidence 13 Activity

Activity

MIC
Antifungal
>256 µM

Target

S.cerevisiae

Source & Reference

dbAMP CAFPdb Antifungipept

Other

aerogenes ATCC 13048 (MIC 64 uM). Inactive: K.pneumoniae ATCC 700603 (MIC>256 uM), fungi S.cerevisiae (MIC>256 uM) and P.pastoris (MIC>256 uM).
Evidence 14 Activity

Activity

MIC
Antifungal
>256 µM

Target

P.pastoris

Source & Reference

dbAMP CAFPdb Antifungipept

Other

uM). Inactive: K.pneumoniae ATCC 700603 (MIC>256 uM), fungi S.cerevisiae (MIC>256 uM) and P.pastoris (MIC>256 uM).
Evidence 15 Activity

Activity

<10% Hemolysis
Toxicity
8 µM
Hemolytic Cytotoxic
<10% Hemolysis | 8 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Identification, Recombinant Expression, and Characterization of LHG2, a Novel Antimicrobial Peptide of Lactobacillus casei HZ1. | Molecules | 2018
Evidence 16 Activity

Activity

<20% Hemolysis
Toxicity
16 µM
Hemolytic Cytotoxic
<20% Hemolysis | 16 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Identification, Recombinant Expression, and Characterization of LHG2, a Novel Antimicrobial Peptide of Lactobacillus casei HZ1. | Molecules | 2018
Evidence 17 Activity

Activity

50% Hemolysis
Toxicity
40 µM
Hemolytic Cytotoxic
50% Hemolysis | 40 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Identification, Recombinant Expression, and Characterization of LHG2, a Novel Antimicrobial Peptide of Lactobacillus casei HZ1. | Molecules | 2018
Evidence 18 Hemolysis

Source & Reference

APD_complete PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.