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Peptide record

TPDB09524

Antibacterial Antifungal Antiviral Toxicity standard

20 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB09524

Activity

Antibacterial Antifungal Antiviral Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia AFP-GFuse Antifungipept CAFPdb dbAMP AI4AVP dbAMP 3.0 DRAVP 2.0 ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 20-aa standard natural multi-activity (Antibacterial, Antifungal, Antiviral, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AFP-GFuse, and other sources, with an available 3D structural model.

Sequence

RLLRRLLRRLLRRLLRRLLR

FASTA

>TPDB09524|Antibacterial;Antifungal;Antiviral;Toxicity|length=20
RLLRRLLRRLLRRLLRRLLR

Formula C120H232N50O21

Absent Amino Acids ANDCEQGHIKMFPSTWYV

Common Amino Acids RL

Mass 2711.48

PI 13.35

Basic Residues 10

Acidic Residues 0

Hydrophobic Residues 10

Net Charge +10

Boman Index 2.50

Hydrophobicity -0.350

Aliphatic Index 195.00

Half Life

Mammalian: 1 hour Yeast: 2 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

Amino Acid Distribution

A: 0 R: 10 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 10 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

Formula

C120H232N50O21

Mass

2711.48

13.35

Net Charge

+10

Boman Index

2.50

Hydrophobicity

-0.350

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

active against Gram- E. coli (MIC 4 ug/ml), P. putida (MIC 2 ug/ml), S. enteritidis (MIC 1 ug/ml), Gram+ B. subtilis (MIC 2 ug/ml),

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2 µg/mL

Target

Target Organism P. putida

Source & Reference

Database Source dbAMP

Other

Evidence Text

active against Gram- E. coli (MIC 4 ug/ml), P. putida (MIC 2 ug/ml), S. enteritidis (MIC 1 ug/ml), Gram+ B. subtilis (MIC 2 ug/ml), S. aureus (MIC 4 ug/ml),

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1 µg/mL

Target

Target Organism S. enteritidis

Source & Reference

Database Source dbAMP

Other

Evidence Text

active against Gram- E. coli (MIC 4 ug/ml), P. putida (MIC 2 ug/ml), S. enteritidis (MIC 1 ug/ml), Gram+ B. subtilis (MIC 2 ug/ml), S. aureus (MIC 4 ug/ml), S. mutans (MIC 2 ug/ml), fungi

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2 µg/mL

Target

Target Organism B. subtilis

Source & Reference

Database Source dbAMP

Other

Evidence Text

Gram- E. coli (MIC 4 ug/ml), P. putida (MIC 2 ug/ml), S. enteritidis (MIC 1 ug/ml), Gram+ B. subtilis (MIC 2 ug/ml), S. aureus (MIC 4 ug/ml), S. mutans (MIC 2 ug/ml), fungi C. neoformans (MIC 1 ug/ml), S.

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP

Other

Evidence Text

, P. putida (MIC 2 ug/ml), S. enteritidis (MIC 1 ug/ml), Gram+ B. subtilis (MIC 2 ug/ml), S. aureus (MIC 4 ug/ml), S. mutans (MIC 2 ug/ml), fungi C. neoformans (MIC 1 ug/ml), S. cerevisiae (MIC 1 ug/ml),

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2 µg/mL

Target

Target Organism S. mutans

Source & Reference

Database Source dbAMP

Other

Evidence Text

, S. enteritidis (MIC 1 ug/ml), Gram+ B. subtilis (MIC 2 ug/ml), S. aureus (MIC 4 ug/ml), S. mutans (MIC 2 ug/ml), fungi C. neoformans (MIC 1 ug/ml), S. cerevisiae (MIC 1 ug/ml), and C. albicans (MIC 1 u

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1 µg/mL

Target

Target Organism C. neoformans

Source & Reference

Database Source dbAMP

Other

Evidence Text

Gram+ B. subtilis (MIC 2 ug/ml), S. aureus (MIC 4 ug/ml), S. mutans (MIC 2 ug/ml), fungi C. neoformans (MIC 1 ug/ml), S. cerevisiae (MIC 1 ug/ml), and C. albicans (MIC 1 ug/ml).

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1 µg/mL

Target

Target Organism S. cerevisiae

Source & Reference

Database Source dbAMP

Other

Evidence Text

ml), S. aureus (MIC 4 ug/ml), S. mutans (MIC 2 ug/ml), fungi C. neoformans (MIC 1 ug/ml), S. cerevisiae (MIC 1 ug/ml), and C. albicans (MIC 1 ug/ml).

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP

Other

Evidence Text

mutans (MIC 2 ug/ml), fungi C. neoformans (MIC 1 ug/ml), S. cerevisiae (MIC 1 ug/ml), and C. albicans (MIC 1 ug/ml).

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.

Evidence Text

active against Gram- E. coli (MIC 4 ug/ml), P. putida (MIC 2 ug/ml), S. enteritidis (MIC 1 ug/ml), Gram+ B. subtilis (MIC 2 ug/ml),

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2 µg/mL

Target

Target Organism P. putida

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

active against Gram- E. coli (MIC 4 ug/ml), P. putida (MIC 2 ug/ml), S. enteritidis (MIC 1 ug/ml), Gram+ B. subtilis (MIC 2 ug/ml), S. aureus (MIC 4 ug/ml),

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1 µg/mL

Target

Target Organism S. enteritidis

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

active against Gram- E. coli (MIC 4 ug/ml), P. putida (MIC 2 ug/ml), S. enteritidis (MIC 1 ug/ml), Gram+ B. subtilis (MIC 2 ug/ml), S. aureus (MIC 4 ug/ml), S. mutans (MIC 2 ug/ml), fungi

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2 µg/mL

Target

Target Organism B. subtilis

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2 µg/mL

Target

Target Organism S. mutans

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1 µg/mL

Target

Target Organism C. neoformans

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Gram+ B. subtilis (MIC 2 ug/ml), S. aureus (MIC 4 ug/ml), S. mutans (MIC 2 ug/ml), fungi C. neoformans (MIC 1 ug/ml), S. cerevisiae (MIC 1 ug/ml), and C. albicans (MIC 1 ug/ml).

Evidence 17 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1 µg/mL

Target

Target Organism S. cerevisiae

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

ml), S. aureus (MIC 4 ug/ml), S. mutans (MIC 2 ug/ml), fungi C. neoformans (MIC 1 ug/ml), S. cerevisiae (MIC 1 ug/ml), and C. albicans (MIC 1 ug/ml).

Evidence 18 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

mutans (MIC 2 ug/ml), fungi C. neoformans (MIC 1 ug/ml), S. cerevisiae (MIC 1 ug/ml), and C. albicans (MIC 1 ug/ml).

Evidence 19 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 4 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP 3.0 DRAVP 2.0

Other

Source Activity Label	Source Definition
Antiviral	dbAMP 3.0 classified under the Anti-viral function class.

Evidence Text

active against Gram- E. coli (MIC 4 ug/ml), P. putida (MIC 2 ug/ml), S. enteritidis (MIC 1 ug/ml), Gram+ B. subtilis (MIC 2 ug/ml),

Evidence 20 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 2 µg/mL

Target

Target Organism P. putida

Source & Reference

Database Source dbAMP 3.0 DRAVP 2.0

Other

Evidence Text

active against Gram- E. coli (MIC 4 ug/ml), P. putida (MIC 2 ug/ml), S. enteritidis (MIC 1 ug/ml), Gram+ B. subtilis (MIC 2 ug/ml), S. aureus (MIC 4 ug/ml),

Evidence 21 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 1 µg/mL

Target

Target Organism S. enteritidis

Source & Reference

Database Source dbAMP 3.0 DRAVP 2.0

Other

Evidence Text

active against Gram- E. coli (MIC 4 ug/ml), P. putida (MIC 2 ug/ml), S. enteritidis (MIC 1 ug/ml), Gram+ B. subtilis (MIC 2 ug/ml), S. aureus (MIC 4 ug/ml), S. mutans (MIC 2 ug/ml), fungi

Evidence 22 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 2 µg/mL

Target

Target Organism B. subtilis

Source & Reference

Database Source dbAMP 3.0 DRAVP 2.0

Other

Evidence Text

Evidence 23 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 4 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP 3.0 DRAVP 2.0

Other

Evidence Text

Evidence 24 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 2 µg/mL

Target

Target Organism S. mutans

Source & Reference

Database Source dbAMP 3.0 DRAVP 2.0

Other

Evidence Text

Evidence 25 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 1 µg/mL

Target

Target Organism C. neoformans

Source & Reference

Database Source dbAMP 3.0 DRAVP 2.0

Other

Evidence Text

Gram+ B. subtilis (MIC 2 ug/ml), S. aureus (MIC 4 ug/ml), S. mutans (MIC 2 ug/ml), fungi C. neoformans (MIC 1 ug/ml), S. cerevisiae (MIC 1 ug/ml), and C. albicans (MIC 1 ug/ml).

Evidence 26 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 1 µg/mL

Target

Target Organism S. cerevisiae

Source & Reference

Database Source dbAMP 3.0 DRAVP 2.0

Other

Evidence Text

ml), S. aureus (MIC 4 ug/ml), S. mutans (MIC 2 ug/ml), fungi C. neoformans (MIC 1 ug/ml), S. cerevisiae (MIC 1 ug/ml), and C. albicans (MIC 1 ug/ml).

Evidence 27 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 1 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP 3.0 DRAVP 2.0

Other

Evidence Text

mutans (MIC 2 ug/ml), fungi C. neoformans (MIC 1 ug/ml), S. cerevisiae (MIC 1 ug/ml), and C. albicans (MIC 1 ug/ml).