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Peptide record

TPDB09499

Antibacterial Antifungal Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB09499
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP
standard
No
A 20-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
KIAKVALKALKIAKVALKAL
Physicochemical Analysis
C100H188N26O21
RNDCEQGHMFPSTWY
AK
2090.75
11.21
6
0
14
+6
2.20
1.000
176.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
6
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
2
I
4
L
6
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 6 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 4 K: 6 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
20
C100H188N26O21
2090.75
11.21
+6
2.20
1.000
Evidence Records 2 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
270±30 µM
Hemolytic Cytotoxic
50% Hemolysis | 270±30 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
PGLa-H tandem-repeat peptides active against multidrug resistant clinical bacterial isolates. | Biochim Biophys Acta | 2017
Evidence 2 Activity

Activity

CC50
Toxicity
>32 µg/mL
Cytotoxic
CC50 | >32 | µg/mL | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Glycine Substitution Reduces Antimicrobial Activity and Helical Stretch of diPGLa-H in Lipid Micelles. | J Phys Chem B | 2017