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Peptide record

TPDB09470

Antibacterial Anticancer Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB09470
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 20-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GATYAKKIIKTITKIATTAW
Physicochemical Analysis
C102H171N25O27
RNDCEQHLMFPSV
T
2179.63
10.64
4
0
10
+4
-0.04
0.175
98.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
6990
320.70
6
Residue Composition
number
4
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
4
I
0
L
4
K
0
M
0
F
0
P
0
S
5
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 4 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 4 L: 0 K: 4 M: 0 F: 0 P: 0 S: 0 T: 5 W: 1 Y: 1 V: 0
Chemical Descriptors
20
C102H171N25O27
2179.63
10.64
+4
-0.04
0.175
Evidence Records 3 records
Evidence 1 Activity

Activity

<5% Hemolysis
Toxicity
128 µg/mL
Hemolytic Cytotoxic
<5% Hemolysis | 128 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design and synthesis of cationic antimicrobial peptides with improved activity and selectivity against Vibrio spp. | Int J Antimicrob Agents | 2008
Evidence 2 Activity

Activity

IC50
Toxicity
336.9 µM
Cytotoxic
IC50 | 336.9 | µM | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
Novel cationic antimicrobial peptide GW-H1 induced caspase-dependent apoptosis of hepatocellular carcinoma cell lines. | Peptides | 2012
Evidence 3 Activity

Activity

MHC
Toxicity
128 µM
Hemolytic
Hemolytic_activity: [Ref.18586467] MHC=128 µM against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Int J Antimicrob Agents. 2008 Aug 32(2):130-8. doi: 10.1016/j.ijantimicag.2008.04.003.