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Peptide record

TPDB09457

Antibacterial Hemolysis Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB09457
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia PD_Hemolysis
standard
No
A 20-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FRIRVRVAKKFGKAFVGEIM
Physicochemical Analysis
C110H182N32O23S1
NDCQHLPSTWY
RKFV
2352.92
12.14
6
1
11
+5
3.07
0.300
92.50
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
2
A
3
R
0
N
0
D
0
C
1
E
0
Q
2
G
0
H
2
I
0
L
3
K
1
M
3
F
0
P
0
S
0
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 2 R: 3 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 2 H: 0 I: 2 L: 0 K: 3 M: 1 F: 3 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 3
Chemical Descriptors
20
C110H182N32O23S1
2352.92
12.14
+5
3.07
0.300
Evidence Records 6 records
Evidence 1 Activity

Activity

10% Hemolysis
Toxicity
8 µM
Hemolytic Cytotoxic
10% Hemolysis | 8 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
High Specific Selectivity and Membrane-Active Mechanism of Synthetic Cationic Hybrid Antimicrobial Peptides Based on the Peptide FV7. | Int J Mol Sci | 2017
Evidence 2 Activity

Activity

20% Hemolysis
Toxicity
32 µM
Hemolytic Cytotoxic
20% Hemolysis | 32 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
High Specific Selectivity and Membrane-Active Mechanism of Synthetic Cationic Hybrid Antimicrobial Peptides Based on the Peptide FV7. | Int J Mol Sci | 2017
Evidence 3 Activity

Activity

35% Hemolysis
Toxicity
64 µM
Hemolytic Cytotoxic
35% Hemolysis | 64 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
High Specific Selectivity and Membrane-Active Mechanism of Synthetic Cationic Hybrid Antimicrobial Peptides Based on the Peptide FV7. | Int J Mol Sci | 2017
Evidence 4 Activity

Activity

50% Hemolysis
Toxicity
128 µM
Hemolytic Cytotoxic
50% Hemolysis | 128 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
High Specific Selectivity and Membrane-Active Mechanism of Synthetic Cationic Hybrid Antimicrobial Peptides Based on the Peptide FV7. | Int J Mol Sci | 2017
Evidence 5 Activity

Activity

% Hemolysis
Toxicity
1 %
Hemolytic
Hemolytic_activity: [Ref.28178190] 1% hemolysis at 2 µM, 8% hemolysis at 4 µM, 10% hemolysis at 8 µM, 15% hemolysis at 16 µM, 20% hemolysis at 32 µM, 37% hemolysis at 64 µM, 55% hemolysis at 128 µM against human red cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Int J Mol Sci. 2017 Feb 6 18(2).
Evidence 6 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis