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Peptide record

TPDB09453

Antibacterial Anticancer Antifungal Hemolysis Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB09453
Antibacterial Anticancer Antifungal Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP PD_Hemolysis
standard
No
A 20-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
FLPLLLAGLPKFLCLVFKKC
Physicochemical Analysis
C113H183N23O21S2
RNDEQHIMSTWY
L
2263.96
9.80
3
0
12
+3
-4.01
1.535
156.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
125
5.52
2
Residue Composition
number
1
A
0
R
0
N
0
D
2
C
0
E
0
Q
1
G
0
H
0
I
7
L
3
K
0
M
3
F
2
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 7 K: 3 M: 0 F: 3 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
20
C113H183N23O21S2
2263.96
9.80
+3
-4.01
1.535
Evidence Records 4 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
29.1 µM
Hemolytic Cytotoxic
50% Hemolysis | 29.1 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Identification of novel Amurin-2 variants from the skin secretion of Rana amurensis, and the design of cationicity-enhanced analogues. | Biochem Biophys Res Commun | 2018
Evidence 2 Activity

Activity

IC50
Toxicity
52.1 µM
Cytotoxic
IC50 | 52.1 | µM | target cell: Human microvascular endothelial cells HMEC-1

Target

Human microvascular endothelial cells HMEC-1

Source & Reference

NA
DBAASP
Identification of novel Amurin-2 variants from the skin secretion of Rana amurensis, and the design of cationicity-enhanced analogues. | Biochem Biophys Res Commun | 2018
Evidence 3 Activity

Activity

IC50
Toxicity
52.1 µM
Hemolytic Cytotoxic
Hemolytic_activity: Horse erythrocytes: 50% Hemolysis=29.1 µM | Cytotoxicity: HMEC-1: IC50=52.1 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochem Biophys Res Commun. 2018 Mar 18 497(4):943-949.
Evidence 4 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis