Back to search

Peptide record

TPDB09351

vCPP 0769 vCPP0769 Antibacterial Anticancer Cell-penetrating Peptides standard
20 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB09351
vCPP 0769 vCPP0769
Antibacterial Anticancer Cell-penetrating Peptides
Anti-infective peptides Cancer-related peptides Delivery and barrier-penetrating peptides
AntiBP3 Peptipedia CancerPPD 2.0 CPPsite3.0
standard
No
A 20-aa standard natural multi-activity (Antibacterial, Anticancer, and Cell-penetrating Peptides) peptide sequence curated from AntiBP3, Peptipedia, CancerPPD 2.0, and other sources, with an available 3D structural model.
C-terminal: Amidation
Sequence
RRLTLRQLLGLGSRRRRRSR-NH2
Physicochemical Analysis
C103H196N48O25
ANDCEHIKMFPWYV
R
2507.00
13.30
9
0
5
+9
5.49
-1.405
97.50
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
4
Residue Composition
number
0
A
9
R
0
N
0
D
0
C
0
E
1
Q
2
G
0
H
0
I
5
L
0
K
0
M
0
F
0
P
2
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 9 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 2 H: 0 I: 0 L: 5 K: 0 M: 0 F: 0 P: 0 S: 2 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
20
C103H196N48O25
2507.00
13.30
+9
5.49
-1.405
Amidation
L
Linear
Linear
Free
Anticancer and Cell Penetrating
Capsid protein of the Torque teno douroucouli virus
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 6 records
Evidence 1 Activity

Activity

IC50
IC50 = 9.0 ± 0.1 µM
Anticancer
9.0

Target

Breast Cancer
MDA-MB-231
Breast

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2022

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

IC50
IC50 = 3.5 ± 1.5 µM
Anticancer
3.5

Target

Breast Cancer
BT-20
Breast

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2022
Evidence 3 Activity

Activity

IC50
IC50 = 37.5 ± 1.7 µM
Anticancer
37.5

Target

Breast Cancer
BT-474
Breast

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2022
Evidence 4 Activity

Activity

IC50
IC50 = 21.1 ± 2.0 µM
Anticancer
21.1

Target

Breast Cancer
SK-BR-3
Breast

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2022
Evidence 5 Activity

Activity

Cell-penetrating Peptides

Target

MDA-MB-231 And BT-20 Cells BT-474 And SKBR3 Cells MCF 10A And HS68 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
In vitro
CCCCTTTTTCCCTTCTTSCC
Evidence 6 Activity

Activity

Cell-penetrating Peptides

Target

Staphylococcus aureus (S. aureus) and MRSA, Escherichia coli (E. coli) and Pseudomonas aeruginosa (P. aeruginosa)

Source & Reference

CPPsite3.0
CPPsite3

Other

Non-natural residues Linear L
Protein derived
In vitro
Additional Detail Fields 1 fields
CCCCTTTTTCCCTTCTTSCC