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Peptide record

TPDB09350

vCPP 0667 vCPP0667 Antibacterial Anticancer Cell-penetrating Peptides standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB09350
vCPP 0667 vCPP0667
Antibacterial Anticancer Cell-penetrating Peptides
Anti-infective peptides Cancer-related peptides Delivery and barrier-penetrating peptides
AntiBP3 Peptipedia CancerPPD 2.0 CPPsite3.0
standard
No
A 20-aa standard natural multi-activity (Antibacterial, Anticancer, and Cell-penetrating Peptides) peptide sequence curated from AntiBP3, Peptipedia, CancerPPD 2.0, and other sources, with an available 3D structural model.
C-terminal: Amidation
Sequence
RPRRRATTRRRITTGTRRRR-NH2
Physicochemical Analysis
C102H195N53O26
NDCEQHLKMFSWYV
R
2580.01
13.40
11
0
2
+11
9.59
-2.435
24.50
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
5
Residue Composition
number
1
A
11
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
1
I
0
L
0
K
0
M
0
F
1
P
0
S
5
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 11 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 5 W: 0 Y: 0 V: 0
Chemical Descriptors
20
C102H195N53O26
2580.01
13.40
+11
9.59
-2.435
Amidation
L
Linear
Linear
Free
Anticancer and Cell Penetrating
Capsid protein of the Torque teno douroucouli virus
N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 5 records
Evidence 1 Activity

Activity

IC50
IC50 = 88.8 ± 1.0 µM
Anticancer
88.8

Target

Breast Cancer
BT-20
Breast

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2022

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

IC50
IC50 = 92.8 ± 1.1 µM
Anticancer
92.8

Target

Breast Cancer
BT-474
Breast

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2022
Evidence 3 Activity

Activity

IC50
IC50 = 71.2 ± 1.1 µM
Anticancer
71.2

Target

Breast Cancer
SK-BR-3
Breast

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2022
Evidence 4 Activity

Activity

Cell-penetrating Peptides

Target

MDA-MB-231 And BT-20 Cells BT-474 And SKBR3 Cells MCF 10A And HS68 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
In vitro
CCSSCCCCSCCCCSSCCCCC
Evidence 5 Activity

Activity

Cell-penetrating Peptides

Target

Staphylococcus aureus (S. aureus) and MRSA, Escherichia coli (E. coli) and Pseudomonas aeruginosa (P. aeruginosa)

Source & Reference

CPPsite3.0
CPPsite3

Other

Non-natural residues Linear L
Protein derived
In vitro
Additional Detail Fields 1 fields
CCSSCCCCSCCCCSSCCCCC