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Peptide record

TPDB09312

Antibacterial Antifungal Hemolysis Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB09312
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 20-aa standard-residue multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
AWKVFKRLGIGAVLWVLTWG
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C115H174N28O22
NDCEQHMPSY
GLWV
2300.82
11.64
3
0
13
+3
-0.98
0.900
131.50
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
16500
7.17
1
Residue Composition
number
2
A
1
R
0
N
0
D
0
C
0
E
0
Q
3
G
0
H
1
I
3
L
2
K
0
M
1
F
0
P
0
S
1
T
3
W
0
Y
3
V
Amino Acid Distribution
A: 2 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 1 L: 3 K: 2 M: 0 F: 1 P: 0 S: 0 T: 1 W: 3 Y: 0 V: 3
Chemical Descriptors
20 reviewed residue count
C115H174N28O22 sequence-only estimate (linear, free termini)
2300.82 sequence-only estimate (linear, free termini)
11.64 sequence-only estimate (linear, free termini)
+3 sequence-only estimate (linear, free termini)
-0.98 sequence-only estimate (linear, free termini)
0.900 sequence-only estimate (linear, free termini)
Evidence Records 9 records
Evidence 1 Activity

Activity

0% Hemolysis
Toxicity
0.78 µM
Hemolytic Cytotoxic
0% Hemolysis | 0.78 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design of novel analogues with potent antibiotic activity based on the antimicrobial peptide, HP(2-9)-ME(1-12). | Biotechnol Lett | 2004
Evidence 2 Activity

Activity

13% Hemolysis
Toxicity
1.56 µM
Hemolytic Cytotoxic
13% Hemolysis | 1.56 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design of novel analogues with potent antibiotic activity based on the antimicrobial peptide, HP(2-9)-ME(1-12). | Biotechnol Lett | 2004
Evidence 3 Activity

Activity

29% Hemolysis
Toxicity
3.125 µM
Hemolytic Cytotoxic
29% Hemolysis | 3.125 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design of novel analogues with potent antibiotic activity based on the antimicrobial peptide, HP(2-9)-ME(1-12). | Biotechnol Lett | 2004
Evidence 4 Activity

Activity

30% Hemolysis
Toxicity
6.25 µM
Hemolytic Cytotoxic
30% Hemolysis | 6.25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design of novel analogues with potent antibiotic activity based on the antimicrobial peptide, HP(2-9)-ME(1-12). | Biotechnol Lett | 2004
Evidence 5 Activity

Activity

43% Hemolysis
Toxicity
12.5 µM
Hemolytic Cytotoxic
43% Hemolysis | 12.5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design of novel analogues with potent antibiotic activity based on the antimicrobial peptide, HP(2-9)-ME(1-12). | Biotechnol Lett | 2004
Evidence 6 Activity

Activity

66% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
66% Hemolysis | 25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design of novel analogues with potent antibiotic activity based on the antimicrobial peptide, HP(2-9)-ME(1-12). | Biotechnol Lett | 2004
Evidence 7 Activity

Activity

83% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
83% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design of novel analogues with potent antibiotic activity based on the antimicrobial peptide, HP(2-9)-ME(1-12). | Biotechnol Lett | 2004
Evidence 8 Activity

Activity

98% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
98% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design of novel analogues with potent antibiotic activity based on the antimicrobial peptide, HP(2-9)-ME(1-12). | Biotechnol Lett | 2004
Evidence 9 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis